A 81988
- CAS No.
- 141887-34-5
- Chemical Name:
- A 81988
- Synonyms
- A 81988;Abbott81988;A81988,A-81988;2-(N-Propyl-N-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)amino)pyridine-3-carboxylic acid;3-Pyridinecarboxylic acid, 2-[propyl[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]amino]-
- CBNumber:
- CB61379518
- Molecular Formula:
- C23H22N6O2
- Molecular Weight:
- 414.467
- MDL Number:
- MFCD00913975
- MOL File:
- 141887-34-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
A 81988 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | RFA88734 | 2-(N-Propyl-N-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)amino)pyridine-3-carboxylic acid | 141887-34-5 | 1mg | $1770.47 | 2026-06-05 | Buy |
| CSNpharm | CSN22012 | A81988 | 141887-34-5 | 10mg | $1999 | 2021-12-16 | Buy |
| CSNpharm | CSN22012 | A81988 | 141887-34-5 | 25mg | $3519 | 2021-12-16 | Buy |
A 81988 Chemical Properties,Uses,Production
Uses
A81988 is a potent, competitive, non-peptidic antagonist of angiotensin AT1 receptors.
in vivo
To verify this hypothesis, B2-/- or wild-type mice (B2+/+) are administered a nonpeptide antagonist of Ang II type 1 (AT1) receptors (A81988) from conception through 180 days of age. Untreated B2+/+ and B2-/- served as controls. Blood pressure (BP) and heart rate are monitored with the use of tail-cuff plethysmography at regular intervals. Ventricular weights, diameters, wall thickness, chamber volume, and myocardial fibrosis are measured at 40 and 180 days. No differences are observed in BP, heart rate, and cardiac weight and dimensions between treated and untreated B2+/+. The BP of AT1 antagonist-treated B2-/- is reduced until 70 days; then, it increases to the levels found in untreated B2-/-. AT1 receptor blockade results in a reduction in left ventricular mass, chamber volume, and wall thickness and abrogated myocardial fibrosis in B2-/-[2]. A81988 (A-81988) decreases the BP of Bk2r-/- either in normosodic conditions or after sodium deprivation, whereas in Bk2r+/+ it produces a modest decrease under hyposodic conditions only[3].
References
[1] Hancock AA, et al. [3H]A-81988, a potent, selective, competitive antagonist radioligand for angiotensin AT1 receptors. Eur J Pharmacol. 1994 Mar 15;267(1):49-54. DOI:10.1016/0922-4106(94)90223-2
[2] Madeddu P, et al. Angiotensin II type 1 receptor blockade prevents cardiac remodeling in bradykinin B(2) receptor knockout mice. Hypertension. 2000 Jan;35(1 Pt 2):391-6. DOI:10.1161/01.hyp.35.1.391
[3] Madeddu P, et al. Circulation. 1997 Nov 18;96(10):3570-8. DOI:10.1161/01.cir.96.10.3570
A 81988 Preparation Products And Raw materials
Raw materials
Preparation Products
A 81988 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4853 | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9718 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 27626 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 38999 | 58 |
