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ChemicalBook >> CAS DataBase List >>(6-Bromo-2-pyridinyl)-carbamic acid,1,1-dimethylethyl ester

(6-Bromo-2-pyridinyl)-carbamic acid,1,1-dimethylethyl ester

(6-Bromo-2-pyridinyl)-carbamic acid,1,1-dimethylethyl ester Structure
(6-Bromo-2-pyridinyl)-carbamic acid,1,1-dimethylethyl ester structure
CAS No.
344331-90-4
Chemical Name:
(6-Bromo-2-pyridinyl)-carbamic acid,1,1-dimethylethyl ester
Synonyms
tert-butyl N-(6-bromopyridin-2-yl)carbamate;Cholest-5-en-3-ol,(7α)-;N-Boc-2-AMino-6-broMopyridine;2-(BOC-AMino)-6-broMopyridine;6-BROMO-2-(N-BOC AMINO) PYRIDNE;tert-Butyl 6-bromopyridin-2-ylcarbamate;t-butyl N-(6-bromo-2-pyridinyl)carbamate;6-BROMO-2-TERT-BUTOXYCARBONYLAMINO-PYRIDINE;Benzenemethanesulfonylchloride,9-(trifluoromethyl)-;(6-BroMo-pyridin-2-yl)-carbaMic acid tert-butyl ester
CBNumber:
CB4218474
Molecular Formula:
C10H13BrN2O2
Molecular Weight:
273.13
MDL Number:
MFCD07367929
MOL File:
344331-90-4.mol
MSDS File:
SDS
Last updated:2026-09-12 18:52:37
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(6-Bromo-2-pyridinyl)-carbamic acid,1,1-dimethylethyl ester Properties

Boiling point 299.3±25.0 °C(Predicted)
Density 1.453±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
pka 11.89±0.70(Predicted)
Appearance White to off-white Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
HS Code  2933399990

(6-Bromo-2-pyridinyl)-carbamic acid,1,1-dimethylethyl ester price More Price(55)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific OR959588 2-(Boc-Amino)-6-bromopyridine >99% 344331-90-4 1g $21 2026-06-04 Buy
Apolloscientific OR959588 2-(Boc-Amino)-6-bromopyridine >99% 344331-90-4 5g $88 2026-06-04 Buy
Apolloscientific OR959588 2-(Boc-Amino)-6-bromopyridine >99% 344331-90-4 25g $370 2026-06-04 Buy
Apolloscientific OR959588 2-(Boc-Amino)-6-bromopyridine >99% 344331-90-4 100g $1405 2026-06-04 Buy
Matrix Scientific 081258 tert-Butyl 6-bromopyridin-2-ylcarbamate 344331-90-4 1.00g $341 2026-05-18 Buy
Product number Packaging Price Buy
OR959588 1g $21 Buy
OR959588 5g $88 Buy
OR959588 25g $370 Buy
OR959588 100g $1405 Buy
081258 1.00g $341 Buy

(6-Bromo-2-pyridinyl)-carbamic acid,1,1-dimethylethyl ester Chemical Properties, Uses, Production

Synthesis

2-Amino-6-bromopyridine

19798-81-3

Di-tert-butyl dicarbonate

24424-99-5

(6-BROMO-2-PYRIDINYL)-CARBAMIC ACID,1,1-DIMETHYLETHYL ESTER

344331-90-4

Step 1. Synthesis of 6-bromo-2-Boc-aminopyridine: To a solution of dichloromethane (24 mL) containing 6-bromopyridin-2-amine (3 g, 17.34 mmol), triethylamine (3.14 mL, 22.54 mmol), and DMAP (0.424 g, 3.47 mmol) was slowly added a solution of dichloromethane (6 mL) containing di-tert-butyl dicarbonate (4.83 mL, 20.81 mmol). 20.81 mmol) to a solution of dichloromethane (6 mL). The reaction mixture was stirred at room temperature for about 24 hours. Upon completion of the reaction, the reaction mixture was diluted with water, saturated saline and ethyl acetate. The aqueous layer was separated and extracted with ethyl acetate. The organic layers were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by column chromatography to give 6-bromo-2-tert-butoxycarbonylaminopyridine as a white solid. Yield: 1.67 g. LCMS (m/z): 274.9 [M+H]+; Retention time: 0.54 min (major peak), 0.95 min.

References

[1] Patent: WO2012/101066, 2012, A1. Location in patent: Page/Page column 77
[2] Journal of Medicinal Chemistry, 2010, vol. 53, # 24, p. 8709 - 8715
[3] Patent: WO2017/205536, 2017, A2. Location in patent: Page/Page column 193; 194
[4] Patent: WO2004/113331, 2004, A1. Location in patent: Page 68
[5] Patent: WO2006/53791, 2006, A2. Location in patent: Page/Page column 39-40

(6-Bromo-2-pyridinyl)-carbamic acid,1,1-dimethylethyl ester synthesis

19798-81-3
24424-99-5
344331-90-4
Synthesis of (6-Bromo-2-pyridinyl)-carbamic acid,1,1-dimethylethyl ester from 2-Amino-6-bromopyridine and Di-tert-butyl dicarbonate

(6-Bromo-2-pyridinyl)-carbamic acid,1,1-dimethylethyl ester Preparation Products And Raw materials

Raw materials

Ammonium hydroxide 2,6-Dibromopyridine Acetic anhydride 6-(Di-Boc-amino)-2-bromopyridine 2-Amino-6-bromopyridine
tert-Butanol Di-tert-butyl dicarbonate 6-Bromopicolinic acid Carbonic acid, bis(1,1-dimethylethyl) ester Phosgene

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Preparation Products

(6-Bromo-2-pyridinyl)-carbamic acid,1,1-dimethylethyl ester Suppliers

Global Suppliers ( 104)
Supplier Tel Email Country ProdList Advantage
Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd. 21-57721279 18121011378 sales@shydchem.com.cn China 998 56
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 marketing@accelachem.com China 10972 64
Shanghai Paulshine Chemical Co., Ltd. +86-021-37788663 China 186 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Shanghai yirong biology science and technology co., ltd 18049974220 3060526242@qq.com China 999 60
SuZhou ShiYa Biopharmaceuticals, Inc. 86(512)5235 8471 17715136450 sales@shiyabiopharm.com China 4167 58
9ding chemical ( Shanghai) Limited 4009209199 sales@9dingchem.com China 18201 56
Shanghai Aladdin Bio-Chem Technology Co.,LTD 400-6206333 13167063860 anhua.mao@aladdin-e.com China 29985 65
SynAsst Chemical. 021-60343070 China 12731 55
Supplier Advantage
Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd. 56
Adamas Reagent, Ltd. 59
Accela ChemBio Co.,Ltd. 64
Shanghai Paulshine Chemical Co., Ltd. 64
Shanghai Hanhong Scientific Co.,Ltd. 64
Shanghai yirong biology science and technology co., ltd 60
SuZhou ShiYa Biopharmaceuticals, Inc. 58
9ding chemical ( Shanghai) Limited 56
Shanghai Aladdin Bio-Chem Technology Co.,LTD 65
SynAsst Chemical. 55

(6-Bromo-2-pyridinyl)-carbamic acid,1,1-dimethylethyl ester Spectrum

(6-BROMO-2-PYRIDINYL)-CARBAMIC ACID,1,1-DIMETHYLETHYL ESTER(344331-90-4)1HNMR

344331-90-4 ((6-Bromo-2-pyridinyl)-carbamic acid,1,1-dimethylethyl ester) Related Search:

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6-BROMO-2-TERT-BUTOXYCARBONYLAMINO-PYRIDINE N-Boc-2-AMino-6-broMopyridine Carbamic acid,N-(6-bromo-2-pyridinyl)-,1,1-dimethylethyl ester tert-Butyl 6-bromopyridin-2-ylcarbamate t-butyl N-(6-bromo-2-pyridinyl)carbamate (6-BroMo-pyridin-2-yl)-carbaMic acid tert-butyl ester 2-(BOC-AMino)-6-broMopyridine Cholest-5-en-3-ol,(7α)- Benzenemethanesulfonylchloride,9-(trifluoromethyl)- 6-BROMO-2-(N-BOC AMINO) PYRIDNE tert-butyl N-(6-bromopyridin-2-yl)carbamate (6-Bromo-2-pyridinyl)-carbamic acid,1,1-dimethylethyl ester 344331-90-4 pharmacetical