2-Amino-6-bromopyridine
- CAS No.
- 19798-81-3
- Chemical Name:
- 2-Amino-6-bromopyridine
- Synonyms
- 6-Bromopyridin-2-amine;2-AMINO-6-BROMO-PHENOL;6-BROMO-PYRIDIN-2-YLAMINE; 19798-81-3;Aminobromopyridine;2-AMINO-6-BROMPYRIDINE;6-BROMO-2-AMINOPYRIDINE;2A6BP;6-BROMO-2-PYRIDINAMINE;2-Bromo-6-Aminopyridine
- CBNumber:
- CB4471572
- Molecular Formula:
- C5H5BrN2
- Molecular Weight:
- 173.01
- MDL Number:
- MFCD00137843
- MOL File:
- 19798-81-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 88-91 °C (lit.) |
|---|---|
| Boiling point | 273.0±20.0 °C(Predicted) |
| Density | 1.710±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), Methanol (Very Slightly) |
| pka | 2.73±0.24(Predicted) |
| form | Powder |
| color | Slightly yellow to light brown |
| Water Solubility | Slightly soluble in water. |
| InChI | InChI=1S/C5H5BrN2/c6-4-2-1-3-5(7)8-4/h1-3H,(H2,7,8) |
| InChIKey | BKLJUYPLUWUEOQ-UHFFFAOYSA-N |
| SMILES | C1(N)=NC(Br)=CC=C1 |
| CAS DataBase Reference | 19798-81-3(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-20/21/22 | |||||||||
| Safety Statements | 26-36-36/37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29333999 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
2-Amino-6-bromopyridine price More Price(92)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 521744 | 2-Amino-6-bromopyridine 98% | 19798-81-3 | 5g | $48.9 | 2026-04-30 | Buy |
| Sigma-Aldrich | 521744 | 2-Amino-6-bromopyridine 98% | 19798-81-3 | 25g | $114 | 2026-04-30 | Buy |
| TCI Chemical | A1529 | 2-Amino-6-bromopyridine >98.0%(T) | 19798-81-3 | 5g | $45 | 2026-04-30 | Buy |
| TCI Chemical | A1529 | 2-Amino-6-bromopyridine >98.0%(T) | 19798-81-3 | 25g | $128 | 2026-04-30 | Buy |
| Usbiological | 258282 | 2-Amino-6-bromopyridine Asreported | 19798-81-3 | 10g | $359 | 2026-06-03 | Buy |
2-Amino-6-bromopyridine Chemical Properties,Uses,Production
Chemical Properties
Slightly yellow to light brown powder
Uses
2-Amino-6-bromopyridine is a disubstituted pyridine used as a building block in the preparation of nitrogen containing bicyclic and polycylic compounds.
Uses
Employed in an efficient one-pot synthesis of 7-azaindoles. Used in the synthesis of anti-HIV agents.
Application
2-Amino-6-bromopyridine is an important raw material for the synthesis of:
2-amino-6-diethylaminopyridine
2,6-di-(methylamino)-pyridine
3-(6-bromopyridin-2-yl)-2-(2,6-difluorophenyl)-1,3-thiazolidin-4-one
N-(6-bromopyridin-2-yl)dodecylamide
2-bromo-6-iodopyridine
Employed in an efficient one-pot synthesis of 7-azaindoles.
Used in the synthesis of anti-HIV agents.
General Description
2-Amino- 6-bromopyridine has been synthesized from epichlorohydrin.
Synthesis
626-05-1
141-86-6
19798-81-3
14.1 Preparation of 6-bromo-2-aminopyridine In a steel autoclave equipped with a glass liner, 10.00 g of 2,6-dibromopyridine (42.2 mmol) was suspended in 50 mL of concentrated ammonia. The autoclave was sealed and heated to 190°C using a heating jacket and maintained for 6 hours (pressure was raised to about 25 bar). After the autoclave was cooled and depressurized, the reaction mixture was mixed with 100 mL of ethyl acetate for phase separation. The aqueous phase was extracted twice with ethyl acetate, 100 mL each. the organic phases were combined, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was dissolved in 250 mL of a solvent mixture of cyclohexane/ethyl acetate (1:1, v/v) to remove the by-product 2,6-diaminopyridine. Subsequently, the solution was filtered through a short silica gel column (5 x 20 cm) and washed again with 250 mL of cyclohexane/ethyl acetate (1:1, v/v) mixed solvent. After removal of the solvent under reduced pressure, the residue was sublimated at 90°C and 10-1 mbar to give 6.49 g (37.5 mmol, 88.9% yield) of 6-bromo-2-aminopyridine as a white solid.
References
[1] Patent: US2004/199024, 2004, A1. Location in patent: Page 17
[2] Recueil des Travaux Chimiques des Pays-Bas, 1932, vol. 51, p. 381,386, 949
[3] Chemical Communications, 2010, vol. 46, # 6, p. 925 - 927
2-Amino-6-bromopyridine Preparation Products And Raw materials
Raw materials
Preparation Products
1of3
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shandong Bailong Pharmaceutical Co., Ltd. | 15562090112 | 3131095341@qq.com | China | 318 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
| Jinan LuoHe PharmaTech Co., Ltd. | 86-0531-68658065 15726150375 | 1071018499@qq.com | China | 525 | 58 |
| Fuxin Custchem Fine Chemical Co., Ltd. | 0418-5113999 18740177324 | sales@custchem.com.cn | China | 448 | 58 |
| Nantong Enwang New Materials Co.,Ltd | 18912257866 | 739904460@qq.com | China | 59 | 58 |
| Jiangxi Hechun Pharmaceutical Technology Co., Ltd. | 13033833208 | 3692193759@qq.com | China | 72 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | 021-50182298 021-50180596 | sales@boylechem.com | China | 2202 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
View Lastest Price from 2-Amino-6-bromopyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 6-Bromopyridin-2-amine
19798-81-3
|
$1.00-200.00 | 1KG | 99%, 99.5% Sublimated | Henan Fengda Chemical Co., Ltd | ||
 |
2026-08-20 | 2-Amino-6-bromopyridine
19798-81-3
|
$1.10 | 1g | 99.00% | 100 Tons min | Dideu Industries Group Limited | |
 |
2026-07-15 | 2-Amino-6-bromopyridine
19798-81-3
|
$29.00 | 99.98% | 10g | TargetMol Chemicals Inc. |
-
- 6-Bromopyridin-2-amine
19798-81-3
- $1.00-200.00
- 99%, 99.5% Sublimated
- Henan Fengda Chemical Co., Ltd
-
- 2-Amino-6-bromopyridine
19798-81-3
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 2-Amino-6-bromopyridine
19798-81-3
- $29.00
- 99.98%
- TargetMol Chemicals Inc.
