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Isochlorogenic acid C

Isochlorogenic acid C Structure
Isochlorogenic acid C structure
CAS No.
57378-72-0
Chemical Name:
Isochlorogenic acid C
Synonyms
4,5-Dicaffeoylquinic acid;3,4-O-Dicaffeoylquinic acid;Isochlorogenic acid C;Isochlorogenic acid C(4,5');3,4-Dicaffeoylquinic acid-RM;4,5-Dicaffeoylquinic acid, >99%;Isochlorogenic acid C USP/EP/BP;Isochlorogenic acid C in Methanol;4,5-Dicaffeoylquinic acid, 10 mM in DMSO;3,4-Dicaffeoylquinic acid|||Isochlorogenic acid C
CBNumber:
CB42201548
Molecular Formula:
C25H24O12
Molecular Weight:
516.45
MDL Number:
MFCD10566623
MOL File:
57378-72-0.mol
MSDS File:
SDS
Last updated:2026-08-20 20:20:01
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Isochlorogenic acid C Properties

Boiling point 810.8±65.0 °C(Predicted)
Density 1+-.0.1 g/cm3(Predicted)
storage temp. Inert atmosphere,Store in freezer, under -20°C
solubility DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:5): 0.16 mg/ml; DMSO: 5 mg/ml
form A solid
pka 3.70±0.50(Predicted)
color White to off-white
InChIKey UFCLZKMFXSILNL-GCBRTHAASA-N
SMILES [C@@]1(O)(C(O)=O)C[C@@H](O)[C@H](OC(=O)C=CC2=CC=C(O)C(O)=C2)[C@H](OC(=O)C=CC2=CC=C(O)C(O)=C2)C1
FDA UNII E57A0DKE0B
UNSPSC Code 41116107
NACRES NA.25

SAFETY

Risk and Safety Statements

WGK Germany  3
Storage Class 11 - Combustible Solids

Isochlorogenic acid C price More Price(69)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SMB00221 4,5-Di-O-caffeoylquinic acid ≥85% (LC/MS-ELSD) 57378-72-0 1mg $521 2026-04-30 Buy
Sigma-Aldrich PHL80425 3,4-Dicaffeoylquinic acid phyproof? Reference Substance 57378-72-0 10mg $516 2026-04-30 Buy
Cayman Chemical 27892 4,5-Dicaffeoylquinic Acid ≥98% 57378-72-0 5mg $116 2026-04-30 Buy
Cayman Chemical 27892 4,5-Dicaffeoylquinic Acid ≥98% 57378-72-0 10mg $185 2026-04-30 Buy
Cayman Chemical 27892 4,5-Dicaffeoylquinic Acid ≥98% 57378-72-0 25mg $434 2026-04-30 Buy
Product number Packaging Price Buy
SMB00221 1mg $521 Buy
PHL80425 10mg $516 Buy
27892 5mg $116 Buy
27892 10mg $185 Buy
27892 25mg $434 Buy

Isochlorogenic acid C Chemical Properties, Uses, Production

Description

4,5-Dicaffeoylquinic acid (4,5-DCQA) is a polyphenol originally isolated from G. fagetorum and G. pseudomollugo that has diverse biological activities, including anti-HIV replication, antioxidative, anti-inflammatory, and anti-melanogenic properties. It inhibits HIV-1 integrase 3'' end processing, 3’ end joining, and disintegration with IC50 values of 0.13, 0.24, and 0.3 μg/ml, respectively. It also inhibits HIV-1 replication in MT-2 T lymphoblastoid cells with an EC50 value of 2 μg/ml. 4,5-DCQA scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in a cell-free assay (IC50 = 19.8 μM) and inhibits superoxide production in human neutrophils activated by N-formyl-Met-Leu-Phe (fMLF; ) and cytochalasin B (; IC50 = 1.49 μM). It decreases prostaglandin E2 (PGE2; ) production in LPS-stimulated U937 cells when used at concentrations of 5 and 10 μg/ml but increases it when used at 200 μg/ml and increases production of TNF-α at concentrations ranging from 5 to 200 μg/ml. It inhibits the synthesis of MCP3 in U937 cells. 4,5-DCQA (25 μM) inhibits melanogenesis by 84% and decreases the levels of proteins involved in melanin biosynthesis, including tyrosinase, TRP-1, DCT, and MITF in B16F1 murine melanocytes.

Uses

4,5-Dicaffeoylquinic Acid is a selective inhibitor of human immunodeficiency virus type 1 integrase.

Definition

ChEBI: 4,5-di-O-caffeoylquinic acid is a quinic acid.

in vivo

4,5-Dicaffeoylquinic acid enhances the expression of GLUT2, GK, and PDX-1 protein, and effectively alleviate glycaemia and insulin resistance and enhance insulin sensitivity in type 2 diabetic mice[1].

References

[1] A. K. BOGAEVSKII  M. I B  L I Dranik. The hydroxycinnamic acids of Galium fagetorum and G. pseudomollugo[J]. Chemistry of Natural Compounds, 1970, 6 6: 761-762. DOI: 10.1007/bf00565353
[2] YU-LI CHEN. Ilex kaushue and Its Bioactive Component 3,5-Dicaffeoylquinic Acid Protected Mice from Lipopolysaccharide-Induced Acute Lung Injury[J]. Scientific Reports, 2016, 6 1. DOI: 10.1038/srep34243
[3] M. D. SANTOS. Effects of Caffeoylquinic Acid Derivatives and C-Flavonoid from Lychnophora ericoides on in vitro Inflammatory Mediator Production[J]. Natural Product Communications, 2010, 35 1. DOI: 10.1177/1934578x1000500512
[4] JI HOON HA  Soo N P. Mechanism underlying inhibitory effect of six dicaffeoylquinic acid isomers on melanogenesis and the computational molecular modeling studies[J]. Bioorganic & Medicinal Chemistry, 2018, 26 14: Pages 4201-4208. DOI: 10.1016/j.bmc.2018.07.014

Isochlorogenic acid C Preparation Products And Raw materials

Raw materials

Preparation Products

Isochlorogenic acid C Suppliers

Global Suppliers ( 198)
Supplier Tel Email Country ProdList Advantage
Chengdu RefMedic Biotech Co Ltd 028-82253651 18140204969 sales@refmedic.com China 2258 58
Shanghai Standard Technology Co.,Ltd. 021-021-57127007-6622-6622 17621252073 luzh@nature-standard.com China 3021 58
Chengdu Push Bio-Technology Co., Ltd. 028-85370565-229 18080489829 18080489829@163.com China 8379 60
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 5996 61
Chengdu Biopurify Phytochemicals Ltd. +86-028-82633397 18982077548 cwb1@biopurify.cn China 2376 60
Beijing HuaMeiHuLiBiological Chemical 010-56205725 waley188@sohu.com China 12323 58
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7545 61
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn United States 4853 58
Shanghai Tauto Biotech Co., Ltd. 021-51320588 tauto@tautobiotech.com China 3984 66
TargetMol Chemicals Inc. 021-021-33632979 15002134094 marketing@targetmol.com China 7993 58
Supplier Advantage
Chengdu RefMedic Biotech Co Ltd 58
Shanghai Standard Technology Co.,Ltd. 58
Chengdu Push Bio-Technology Co., Ltd. 60
Chembest Research Laboratories Limited 61
Chengdu Biopurify Phytochemicals Ltd. 60
Beijing HuaMeiHuLiBiological Chemical 58
Haoyuan Chemexpress Co., Ltd. 61
MedChemexpress LLC 58
Shanghai Tauto Biotech Co., Ltd. 66
TargetMol Chemicals Inc. 58

View Latest Price from Isochlorogenic acid C manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4,5-Dicaffeoylquinic acid pictures 2026-08-18 4,5-Dicaffeoylquinic acid
57378-72-0
 $38.00-117.00 99.92% 10g TargetMol Chemicals Inc.
Isochlorogenic acid C pictures 2023-02-24 Isochlorogenic acid C
57378-72-0
 5mg ≥98%(HPLC) 10 g Shanghai Standard Technology Co., Ltd.

Isochlorogenic acid C Spectrum

Isochlorogenic acid C(57378-72-0)1HNMR

57378-72-0 (Isochlorogenic acid C) Related Search:

Isochlorogenic acid C BAVACHININ A epiberberine Isochlorogenic Acid B glaucocalyxin A
Taxifolin Isochlorogenic acid A (E,E)-3,5-Di-O-caffeoylquinic acid Isocitric acid trisodium salt Fluorescein isothiocyanate
Isoastilbin Cryptochlorogenic acid Chlorogenic acid CYNARIN 1,3,5-Tricaffeoylquinic acid
1-Caffeoylquinic acid 2,3,4,5-Tetracaffeoyl-D-Glucaric acid Caftaric acid

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Isochlorogenic acid C (1R)-1,3β-Dihydroxy-4α,5α-bis[3-(3,4-dihydroxyphenyl)acryloyloxy]-1β-cyclohexanecarboxylic acid (1R,3R,4S,5R)-1,5-Dihydroxy-3,4-bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]oxy]-1-cyclohexanecarboxylic acid 1β,5α-Dihydroxy-3β,4β-bis[3-(3,4-dihydroxyphenyl)propenoyloxy]cyclohexanecarboxylic acid Isochlorogenic acid C(4,5') 4,5-Dicaffeoylquinic acid 4,5-Dicaffeoylquinic acid, >99% Cyclohexanecarboxylic acid, 3,4-bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-1,5-dihydroxy-, (1R,3R,4S,5R)- (1R,3R,4S,5R)-3,4-Bis((3-(3,4-dihydroxyphenyl)acryloyl)oxy)-1,5-dihydroxycyclohexanecarboxylic acid (1R,3R,4S,5R)-1,5-Dihydroxy-3,4-bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]oxy]-1-cyclohexanecarboxylicaci Isochlorogenic acid C USP/EP/BP 3,4-Dicaffeoylquinic acid|||Isochlorogenic acid C 3,4-Dicaffeoylquinic acid-RM Isochlorogenic acid C in Methanol 4,5-Dicaffeoylquinic acid, 10 mM in DMSO 3,4-O-Dicaffeoylquinic acid 57378-72-0