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Isochlorogenic acid C

Isochlorogenic acid C structure

CAS No.: 57378-72-0

Chemical Name:: Isochlorogenic acid C

Synonyms: 4,5-Dicaffeoylquinic acid;3,4-O-Dicaffeoylquinic acid;Isochlorogenic acid C;Isochlorogenic acid C(4,5');3,4-Dicaffeoylquinic acid-RM;4,5-Dicaffeoylquinic acid, >99%;Isochlorogenic acid C USP/EP/BP;Isochlorogenic acid C in Methanol;4,5-Dicaffeoylquinic acid, 10 mM in DMSO;3,4-Dicaffeoylquinic acid|||Isochlorogenic acid C

CBNumber:: CB42201548

Molecular Formula:: C25H24O12

Molecular Weight:: 516.45

MDL Number:: MFCD10566623

MOL File:: 57378-72-0.mol

MSDS File:: SDS

Last updated:2025-10-09 14:55:14

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Isochlorogenic acid C Properties

Boiling point	810.8±65.0 °C(Predicted)
Density	1?+-.0.1 g/cm3(Predicted)
storage temp.	Inert atmosphere,Store in freezer, under -20°C
solubility	DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:5): 0.16 mg/ml; DMSO: 5 mg/ml
form	A solid
pka	3.70±0.50(Predicted)
color	White to off-white
InChIKey	UFCLZKMFXSILNL-GCBRTHAASA-N
SMILES	[C@@]1(O)(C(O)=O)C[C@@H](O)[C@H](OC(=O)C=CC2=CC=C(O)C(O)=C2)[C@H](OC(=O)C=CC2=CC=C(O)C(O)=C2)C1
FDA UNII	E57A0DKE0B
UNSPSC Code	41116107
NACRES	NA.25

SAFETY

Risk and Safety Statements

WGK Germany	3

Isochlorogenic acid C price More Price(28)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SMB00221	4,5-Di-O-caffeoylquinic acid ≥85% (LC/MS-ELSD)	57378-72-0	1mg	$487	2025-07-31	Buy
Sigma-Aldrich	PHL80425	3,4-Dicaffeoylquinic acid phyproof? Reference Substance	57378-72-0	10mg	$481	2025-07-31	Buy
Cayman Chemical	27892	4,5-Dicaffeoylquinic Acid	57378-72-0	25mg	$667	2024-03-01	Buy
Cayman Chemical	27892	4,5-Dicaffeoylquinic Acid	57378-72-0	50mg	$1175	2024-03-01	Buy
Cayman Chemical	27892	4,5-Dicaffeoylquinic Acid	57378-72-0	5mg	$158	2024-03-01	Buy

Product number	Packaging	Price	Buy
SMB00221	1mg	$487	Buy
PHL80425	10mg	$481	Buy
27892	25mg	$667	Buy
27892	50mg	$1175	Buy
27892	5mg	$158	Buy

Isochlorogenic acid C Chemical Properties,Uses,Production

Description

4,5-Dicaffeoylquinic acid (4,5-DCQA) is a polyphenol originally isolated from G. fagetorum and G. pseudomollugo that has diverse biological activities, including anti-HIV replication, antioxidative, anti-inflammatory, and anti-melanogenic properties. It inhibits HIV-1 integrase 3'' end processing, 3’ end joining, and disintegration with IC₅₀ values of 0.13, 0.24, and 0.3 μg/ml, respectively. It also inhibits HIV-1 replication in MT-2 T lymphoblastoid cells with an EC₅₀ value of 2 μg/ml. 4,5-DCQA scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in a cell-free assay (IC₅₀ = 19.8 μM) and inhibits superoxide production in human neutrophils activated by N-formyl-Met-Leu-Phe (fMLF; ) and cytochalasin B (; IC₅₀ = 1.49 μM). It decreases prostaglandin E₂ (PGE₂; ) production in LPS-stimulated U937 cells when used at concentrations of 5 and 10 μg/ml but increases it when used at 200 μg/ml and increases production of TNF-α at concentrations ranging from 5 to 200 μg/ml. It inhibits the synthesis of MCP3 in U937 cells. 4,5-DCQA (25 μM) inhibits melanogenesis by 84% and decreases the levels of proteins involved in melanin biosynthesis, including tyrosinase, TRP-1, DCT, and MITF in B16F1 murine melanocytes.

Uses

4,5-Dicaffeoylquinic Acid is a selective inhibitor of human immunodeficiency virus type 1 integrase.

Definition

ChEBI: 4,5-di-O-caffeoylquinic acid is a quinic acid.

in vivo

4,5-Dicaffeoylquinic acid enhances the expression of GLUT2, GK, and PDX-1 protein, and effectively alleviate glycaemia and insulin resistance and enhance insulin sensitivity in type 2 diabetic mice^[1].

References

[1] A. K. BOGAEVSKII M. I B L I Dranik. The hydroxycinnamic acids of Galium fagetorum and G. pseudomollugo[J]. Chemistry of Natural Compounds, 1970, 6 6: 761-762. DOI: 10.1007/bf00565353
[2] YU-LI CHEN. Ilex kaushue and Its Bioactive Component 3,5-Dicaffeoylquinic Acid Protected Mice from Lipopolysaccharide-Induced Acute Lung Injury[J]. Scientific Reports, 2016, 6 1. DOI: 10.1038/srep34243
[3] M. D. SANTOS. Effects of Caffeoylquinic Acid Derivatives and C-Flavonoid from Lychnophora ericoides on in vitro Inflammatory Mediator Production[J]. Natural Product Communications, 2010, 35 1. DOI: 10.1177/1934578x1000500512
[4] JI HOON HA Soo N P. Mechanism underlying inhibitory effect of six dicaffeoylquinic acid isomers on melanogenesis and the computational molecular modeling studies[J]. Bioorganic & Medicinal Chemistry, 2018, 26 14: Pages 4201-4208. DOI: 10.1016/j.bmc.2018.07.014

Isochlorogenic acid C Preparation Products And Raw materials

Raw materials

Preparation Products

Isochlorogenic acid C Suppliers

Global( 196)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Chengdu Biopurify Phytochemicals Ltd.	+86-28-82633860; +8618080483897	sales@biopurify.com	China	3751	58
Shanghai Standard Technology Co., Ltd.	18502101150	ft-sales@nature-standard.com	CHINA	1923	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49975	58
Wuhan ChemNorm Biotech Co.,Ltd.	+86-27-8439 4403 18971486879	sales@chemnorm.com	CHINA	2935	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32433	58
Hubei Ipure Biology Co., Ltd	+8613367258412	ada@ipurechemical.com	China	10242	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	20391	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	39031	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58

Supplier	Advantage
Chengdu Biopurify Phytochemicals Ltd.	58
Shanghai Standard Technology Co., Ltd.	58
CONIER CHEM AND PHARMA LIMITED	58
Wuhan ChemNorm Biotech Co.,Ltd.	58
TargetMol Chemicals Inc.	58
Hubei Ipure Biology Co., Ltd	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Dideu Industries Group Limited	58
TargetMol Chemicals Inc.	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58

View Lastest Price from Isochlorogenic acid C manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-10-09	4,5-Dicaffeoylquinic acid 57378-72-0	US $38.00-117.00 / mg		99.58%	10g	TargetMol Chemicals Inc.
	2023-02-24	Isochlorogenic acid C 57378-72-0	US $0.00 / mg	5mg	≥98%(HPLC)	10 g	Shanghai Standard Technology Co., Ltd.

4,5-Dicaffeoylquinic acid
57378-72-0
US $38.00-117.00 / mg
99.58%
TargetMol Chemicals Inc.

Isochlorogenic acid C
57378-72-0
US $0.00 / mg
≥98%(HPLC)
Shanghai Standard Technology Co., Ltd.

57378-72-0(Isochlorogenic acid C)Related Search:

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Isochlorogenic acid C (1R)-1,3β-Dihydroxy-4α,5α-bis[3-(3,4-dihydroxyphenyl)acryloyloxy]-1β-cyclohexanecarboxylic acid (1R,3R,4S,5R)-1,5-Dihydroxy-3,4-bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]oxy]-1-cyclohexanecarboxylic acid 1β,5α-Dihydroxy-3β,4β-bis[3-(3,4-dihydroxyphenyl)propenoyloxy]cyclohexanecarboxylic acid 3,4-O-Dicaffeoylquinic acid Isochlorogenic acid C(4,5') 4,5-Dicaffeoylquinic acid 4,5-Dicaffeoylquinic acid, >99% Cyclohexanecarboxylic acid, 3,4-bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-1,5-dihydroxy-, (1R,3R,4S,5R)- (1R,3R,4S,5R)-3,4-Bis((3-(3,4-dihydroxyphenyl)acryloyl)oxy)-1,5-dihydroxycyclohexanecarboxylic acid (1R,3R,4S,5R)-1,5-Dihydroxy-3,4-bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]oxy]-1-cyclohexanecarboxylicaci Isochlorogenic acid C USP/EP/BP 3,4-Dicaffeoylquinic acid|||Isochlorogenic acid C 3,4-Dicaffeoylquinic acid-RM Isochlorogenic acid C in Methanol 4,5-Dicaffeoylquinic acid, 10 mM in DMSO 57378-72-0