Isochlorogenic acid A
- CAS No.
- 2450-53-5
- Chemical Name:
- Isochlorogenic acid A
- Synonyms
- 3,5-Dicaffeoylquinic acid;3,5-CQA;CJ 4-16-4;Isochloric acid A;Isochlorogenic acid A;3,5-Dicaffeylquinic acid;ISOCHLOROGENIC ACID A(SH);3',5'-Isochlorogenic acid A;3,5-Dicaffeoylquinic acid-RM;Quinic acid 3,5-di-O-caffeate
- CBNumber:
- CB81040694
- Molecular Formula:
- C25H24O12
- Molecular Weight:
- 516.46
- MDL Number:
- MFCD00951290
- MOL File:
- 2450-53-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | >175°C (dec.) |
|---|---|
| Boiling point | 826.2±65.0 °C(Predicted) |
| Density | 1+-.0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Off-white to yellow/brown crystalline solid. |
| pka | 3.54±0.50(Predicted) |
| color | Off-White to Pale Yellow |
| Stability | Hygroscopic |
| Major Application |
metabolomics vitamins, nutraceuticals, and natural products |
| InChIKey | KRZBCHWVBQOTNZ-PSEXTPKNSA-N |
| SMILES | O([C@@H]1C[C@](O)(C(=O)O)C[C@@H](OC(=O)C=CC2C=CC(O)=C(O)C=2)[C@H]1O)C(=O)C=CC1C=CC(O)=C(O)C=1 |&1:1,3,9,23,r| |
| FDA UNII | ND94C5E75K |
| UNSPSC Code | 41116107 |
| NACRES | NA.25 |
SAFETY
Risk and Safety Statements
| Safety Statements | 24/25 |
|---|---|
| WGK Germany | 3 |
| RTECS | GU8403966 |
| HS Code | 29189900 |
| Storage Class | 11 - Combustible Solids |
Isochlorogenic acid A price More Price(72)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SMB00131 | 3,5-Di-caffeoylquinic acid ≥95% (LC/MS-ELSD) | 2450-53-5 | 1mg | $345 | 2026-04-30 | Buy |
| Sigma-Aldrich | PHL80426 | 3,5-Dicaffeoylquinic acid phyproof Reference Substance | 2450-53-5 | 10mg | $572 | 2026-04-30 | Buy |
| Cayman Chemical | 24964 | 3,5-Dicaffeoylquinic Acid ≥95% | 2450-53-5 | 5mg | $87 | 2026-04-30 | Buy |
| Cayman Chemical | 24964 | 3,5-Dicaffeoylquinic Acid ≥95% | 2450-53-5 | 10mg | $156 | 2026-04-30 | Buy |
| Cayman Chemical | 24964 | 3,5-Dicaffeoylquinic Acid ≥95% | 2450-53-5 | 25mg | $344 | 2026-04-30 | Buy |
Isochlorogenic acid A Chemical Properties, Uses, Production
Description
3,5-Dicaffeoylquinic acid (3,5-DCQA) is a natural phenolic compound that has been found in L. japonica, I. kaushue, and other plants. It has antioxidant, anti-inflammatory, and antiviral biological activities. 3,5-DCQA scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; ) radicals in a cell-free assay (IC50 = 71.8 μM) and inhibits superoxide production in human neutrophils activated by N-formyl-Met-Leu-Phe (fMLF) and cytochalasin B (IC50 = 1.92 μM). It inhibits HIV-1 integrase 3''-end processing, strand transfer, and disintegration in a cell-free assay (IC50s = 0.33, 0.34, and 0.66 μg/ml, respectively) and inhibits HIV-1-induced cytotoxicity in MT-2 cells (ED50 = 1 μg/ml). In vivo, 3,5-DCQA (25 mg/kg) protects mice from acute lung injury induced by LPS and decreases neutrophil count in bronchoalveolar lavage fluid (BALF).
Chemical Properties
Off-white crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from honeysuckle, honeysuckle, eucommia, and chrysanthemum.
Uses
Isochlorogenic Acid A is a phenolic compound shown to provide protection against oxidative stress cells. DNA protective agent.
Definition
ChEBI: 3,5-di-O-caffeoyl quinic acid is a carboxylic ester that is the diester obtained by the condensation of the hydroxy groups at positions 3 and 5 of (-)-quinic acid with the carboxy group of trans-caffeic acid. Isolated from Brazilian propolis and Suaeda glauca, it exhibits hepatoprotective and cytotoxic activities. It has a role as a metabolite, a hepatoprotective agent and an antineoplastic agent. It is a cyclitol carboxylic acid and a carboxylic ester. It is functionally related to a (-)-quinic acid and a trans-caffeic acid.
in vivo
Isochlorogenic acid A (5and 10 mg/kg, p.o., once a day for 3 weeks) ameliorates cognitive impairment induced by TMT in ICR male mice[5].
| Animal Model: | TMT-induced ICR male mice[5] |
| Dosage: | 5and 10 mg/kg |
| Administration: | p.o., once a day for 3 weeks |
| Result: | Improved spatial memory and learning ability of mice in MWM test. Reduced the TMT-induced increased AChE activity. Reduced the MDA content compared to the TMT group. |
References
[1] LI-YAN PENG. Constituents from Lonicera japonica[J]. Fitoterapia, 2000, 71 6: Pages 713-715. DOI: 10.1016/s0367-326x(00)00212-4
[2] KRISS DAYANA PANTOJA PULIDO José H I M Ana Julia Colmenares Dulcey. New caffeic acid derivative from Tithonia diversifolia (Hemsl.) A. Gray butanolic extract and its antioxidant activity[J]. Food and Chemical Toxicology, 2017, 109: Pages 1079-1085. DOI: 10.1016/j.fct.2017.03.059
[3] W E ROBINSON. Inhibitors of HIV-1 replication [corrected; erratum to be published] that inhibit HIV integrase.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1996, 93 13: 6326-6331. DOI: 10.1073/pnas.93.13.6326
Isochlorogenic acid A Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Yuanzhi Biotechnology Co. Ltd. | 15805159960; | 1211550495@qq.com | China | 1797 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| Sichuan Kulinan Technology Co., Ltd | 400-1166-196 18981987031 | cdhxsj@163.com | China | 11674 | 57 |
| Shenzhen Sungening Bio-Tech Co., Ltd | +86-0755-89668383 | sales@sungening.com | China | 1319 | 65 |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4765 | 58 |
| BioBioPha Co., Ltd. | 0871-65217109 | y.liu@mail.biobiopha.com | China | 5641 | 65 |
| ShangHai YuanYe Biotechnology Co., Ltd. | 15026964105 | shyysw007@163.com | China | 4998 | 60 |
| Chengdu Ai Keda Chemical Technology Co., Ltd. | 4008-755-333 18080918076 | 800078821@qq.com | China | 9706 | 55 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-028-82633397 18982077548 | cwb1@biopurify.cn | China | 2376 | 60 |
View Latest Price from Isochlorogenic acid A manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | Isochlorogenic acid A
2450-53-5
|
$59.00-176.00 | 99.71% | 10g | TargetMol Chemicals Inc. | ||
 |
2019-07-14 | Isochlorogenic acid A
2450-53-5
|
$1.00 | 1KG | 99% | 25kg | Career Henan Chemical Co |
-
- Isochlorogenic acid A
2450-53-5
- $59.00-176.00
- 99.71%
- TargetMol Chemicals Inc.
-
- Isochlorogenic acid A
2450-53-5
- $1.00
- 99%
- Career Henan Chemical Co
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