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Cryptochlorogenic acid

Cryptochlorogenic acid structure

CAS No.: 905-99-7

Chemical Name:: Cryptochlorogenic acid

Synonyms: 4-Caffeoylquinic acid;Cryptochlorogenin Acid;4-Dicaffeoylquinic Acid;Cryptophyllinic acid;Cryptochlorogenic acid;Quinic acid 4-O-caffeate;Cryptochlorogenic acid-RM;Cryptochlorogenic acid(4');4-O-trans-caffeoylquinicaci;4-O-trans-caffeoylquinic acid

CBNumber:: CB81040700

Molecular Formula:: C16H18O9

Molecular Weight:: 354.31

MDL Number:: MFCD10566638

MOL File:: 905-99-7.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 03:57:17

Product description	Number	Pack Size	Price
4-O-Caffeoylquinic acid ≥98.0%	65969	10mg	$372
Cryptochlorogenic acid phyproof? Reference Substance	PHL80393	10MG	$457
4-O-Caffeoylquinic acid ≥98.0%	65969	50mg	$1520
Cryptochlorogenic Acid ≥98%	25098	10mg	$161
Cryptochlorogenic Acid ≥98%	25098	50mg	$722
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Cryptochlorogenic acid Properties

Boiling point	694.9±55.0 °C(Predicted)
Density	1.65
storage temp.	2-8°C
solubility	DMSO : 50 mg/mL (141.12 mM; Need ultrasonic)
form	Solid
pka	4.07±0.50(Predicted)
color	White-pale yellow
optical activity	[α]/D -76.0±5.0°, c = 0.5 in H2O
Stability	Hygroscopic
Major Application	food and beverages
InChI	InChI=1S/C16H18O9/c17-9-3-1-8(5-10(9)18)2-4-13(21)25-14-11(19)6-16(24,15(22)23)7-12(14)20/h1-5,11-12,14,17-20,24H,6-7H2,(H,22,23)/t11-,12-,14-,16+/m1/s1
InChIKey	GYFFKZTYYAFCTR-NCZKRNLISA-N
SMILES	O([C@H]1[C@@H](C[C@](C[C@H]1O)(O)C(=O)O)O)C(=O)C=CC1C=CC(=C(C=1)O)O
FDA UNII	F23DJ84IZ9
UNSPSC Code	85151701
NACRES	NA.28

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
WGK Germany	3
Storage Class	11 - Combustible Solids

Cryptochlorogenic acid price More Price(71)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	65969	4-O-Caffeoylquinic acid ≥98.0%	905-99-7	10mg	$372	2026-04-30	Buy
Sigma-Aldrich	PHL80393	Cryptochlorogenic acid phyproof? Reference Substance	905-99-7	10MG	$457	2026-04-30	Buy
Sigma-Aldrich	65969	4-O-Caffeoylquinic acid ≥98.0%	905-99-7	50mg	$1520	2026-04-30	Buy
Cayman Chemical	25098	Cryptochlorogenic Acid ≥98%	905-99-7	10mg	$161	2026-04-30	Buy
Cayman Chemical	25098	Cryptochlorogenic Acid ≥98%	905-99-7	50mg	$722	2026-04-30	Buy

Product number	Packaging	Price	Buy
65969	10mg	$372	Buy
PHL80393	10MG	$457	Buy
65969	50mg	$1520	Buy
25098	10mg	$161	Buy
25098	50mg	$722	Buy

Cryptochlorogenic acid Chemical Properties,Uses,Production

Chemical Properties

White needle-shaped crystals, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Eucommia ulmoides, Lonicera japonica, and Honeysuckle.

Uses

Cryptochlorogenic acid may be used as a reference standard in the determination of cryptochlorogenic acid in the leaves of Hibiscus sabdariffa using high performance liquid chromatography coupled with mass spectrometry (HPLC-MS).

Uses

4-O-Caffeoylquinic acid has been used as a reference compound for the quantification in high performance liquid chromatography-diode array detector (HPLC-DAD).

Definition

ChEBI: A cinnamate ester obtained by formal condensation of the carboxy group of trans-caffeic acid with the 4-hydroxy group of (+)-quinic acid.

General Description

Cryptochlorogenic acid is a polyphenol, found in a variety of plants, which plays a crucial role in protection against various age-related diseases.

Biochem/physiol Actions

4-O-Caffeoylquinic acid (4-CQA) is a major active antioxidant marker in mulberry leaf extract. It is an inhibitor of ferroptosis hence, it is recognized as a potent anti-diabetic agent. 4-CQA plays an important role in the upregulation of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway.

in vivo

Pharmacokinetic parameters of Cryptochlorogenic acid after intragastric administration of Cryptochlorogenic acid at three dosages^[2]

Dose (mg/kg)	C_max (μg/L)	t_max (h)	t_1/2 (h)	AUC_0-t (μgh/L)	AUC_0-∞ (μgh/L)	MRT_0-t (h)	MRT_0-∞ (h)
100	630	0.33	2.00	1938.91	1977.70	3.21	3.51
200	1270.09	0.47	1.97	3071.87	3179.41	3.23	3.39
400	2582.68	0.44	2.34	8825.32	9139.54	3.47	3.93

IC 50

HIF-1α

Cryptochlorogenic acid Preparation Products And Raw materials

Raw materials

Preparation Products

Cryptochlorogenic acid Suppliers

Global( 282)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shaanxi Dideu Medichem Co. Ltd	+86-17392712779	1097@dideu.com	China	3989	58
Shanghai Zheyan Biotech Co., Ltd.	18017610038	zheyansh@163.com	CHINA	3618	58
Chengdu Greenpure Biopharma CO.,Ltd	18283602253;	jancyzheng@gcgreenpure.com	China	954	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29766	58
Chengdu GLP biotechnology Co Ltd	028-87075086 13350802083	scglp@glp-china.com	CHINA	1824	58
Chengdu Biopurify Phytochemicals Ltd.	+86-28-82633860; +86-18080483897	sales@biopurify.com	China	4616	58
Nanjing Dolon Biotechnology Co.,Ltd.	18905173768	52513593@qq.com	CHINA	2971	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19935	58
Shanghai Standard Technology Co., Ltd.	18502101150	ft-sales@nature-standard.com	CHINA	1922	58
CONIER CHEM AND PHARMA LIMITED		sales@conier.com	China	49906	58

Supplier	Advantage
Shaanxi Dideu Medichem Co. Ltd	58
Shanghai Zheyan Biotech Co., Ltd.	58
Chengdu Greenpure Biopharma CO.,Ltd	58
career henan chemical co	58
Chengdu GLP biotechnology Co Ltd	58
Chengdu Biopurify Phytochemicals Ltd.	58
Nanjing Dolon Biotechnology Co.,Ltd.	58
BOC Sciences	58
Shanghai Standard Technology Co., Ltd.	58
CONIER CHEM AND PHARMA LIMITED	58

View Lastest Price from Cryptochlorogenic acid manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-04-22	Cryptochlorogenic acid 905-99-7	$57.00		99.66%	10g	TargetMol Chemicals Inc.
2025-12-24	Cryptochlorogenic acid 905-99-7		1KG	99.0%	1000KG	Shaanxi Dideu Medichem Co. Ltd
2023-02-24	Cryptochlorogenic acid 905-99-7		5mg	≥98%(HPLC)	10 g	Shanghai Standard Technology Co., Ltd.

Cryptochlorogenic acid
905-99-7
$57.00
99.66%
TargetMol Chemicals Inc.

Cryptochlorogenic acid
905-99-7
99.0%
Shaanxi Dideu Medichem Co. Ltd

Cryptochlorogenic acid
905-99-7
$0.00
≥98%(HPLC)
Shanghai Standard Technology Co., Ltd.

Cryptochlorogenic acid Spectrum

Cryptochlorogenic acid(905-99-7)MS Cryptochlorogenic acid(905-99-7)¹HNMR

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Cryptochlorogenic acid 3,4-Dihydroxycinnamic acid 4-carboxy-2,4,6-trihydroxycyclohexyl ester Quinic acid 4-O-caffeate Cryptochlorogenic acid，4-Caffeoylquinic acid 4-Dicaffeoylquinic Acid 4-Caffeoylquinic acid Quinic acid 4-O-caffeate Cryptochlorogenic acid(4') 4-O-trans-caffeoylquinic acid (1S,3R,4S,5R)-4-(((E)-3-(3,4-dihydroxyphenyl)acryloyl)oxy)-1,3,5-trihydroxycyclohexanecarboxylic acid 4-O-(3,4-Dihydroxycinnamoyl)-D-quinic acid 4-Caffeoylquinic acid/ Cryptochlorogenic acid 4-{[(2E)-3-(3,4-Dihydroxyphenyl)-2-propenoyl]oxy}-1,3,5-trihydroxycyclohexanecarboxylic acid Cyclohexanecarboxylic acid, 4-[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-1,3,5-trihydroxy-, (1α,3R,4α,5R)- 4-O-trans-caffeoylquinicaci (1alpha,3R,4alpha,5R)-4-[[3-(3,4-Dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-1,3,5-trihydroxycyclohexanecarboxylic acid (1S,3R,4S,5R)-4-((3-(3,4-Dihydroxyphenyl)acryloyl)oxy)-1,3,5-trihydroxycyclohexanecarboxylic acid CRYPTOCHLOROGENIC ACID (4-CQA) Cryptochlorogenic acid in Methanol Cryptochlorogenic acid-RM Cryptochlorogenic acid, 10 mM in DMSO 4-O-Caffeoylquinic acid Cyclohexanecarboxylic acid, 4-[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-1,3,5-trihydroxy-, (1α,3R,4α,5R)- Cryptophyllinic acid Cryptochlorogenic acid (Standard) 4-Caffeoylquinic acid Cryptochlorogenin Acid 905-99-7 chemical reagent pharmaceutical intermediate phytochemical reference standards from Chinese medicinal herbs (TCM). standardized herbal extract