5-Methoxyindole
- CAS No.
- 1006-94-6
- Chemical Name:
- 5-Methoxyindole
- Synonyms
- 5-METHOXY-1H-INDOLE;Methoxyindole 99% indol-5-yl methyl ether;5-methoxy-indol;Femedol;NSC 521752;AKOS JY2082918;5-METHOXYINDOLE;methoxy-5indole;5-MethoxyindoleF;Methoxy-5 indole
- CBNumber:
- CB4223553
- Molecular Formula:
- C9H9NO
- Molecular Weight:
- 147.17
- MDL Number:
- MFCD00005674
- MOL File:
- 1006-94-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 52-55 °C (lit.) |
|---|---|
| Boiling point | 176-178 °C/17 mmHg (lit.) |
| Density | 1.1135 (rough estimate) |
| refractive index | 1.5310 (estimate) |
| Flash point | 176-178°C/17mm |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Chloroform, Methanol |
| pka | 16.70±0.30(Predicted) |
| form | Crystalline Powder |
| color | White to light brownish |
| Water Solubility | insoluble |
| Sensitive | Light Sensitive |
| BRN | 116722 |
| InChI | 1S/C9H9NO/c1-11-8-2-3-9-7(6-8)4-5-10-9/h2-6,10H,1H3 |
| InChIKey | DWAQDRSOVMLGRQ-UHFFFAOYSA-N |
| SMILES | COc1ccc2[nH]ccc2c1 |
| CAS DataBase Reference | 1006-94-6(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | DQM3AS43PQ |
| NIST Chemistry Reference | 1H-Indole, 5-methoxy-(1006-94-6) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-24/25-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | NL9500000 | |||||||||
| F | 8 | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | IRRITANT, KEEP COLD, LIGHT SENSITIVE | |||||||||
| HS Code | 29339900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
5-Methoxyindole price More Price(85)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | M14900 | 5-Methoxyindole 99% | 1006-94-6 | 1g | $28.5 | 2026-04-30 | Buy |
| Sigma-Aldrich | M14900 | 5-Methoxyindole 99% | 1006-94-6 | 5g | $38.8 | 2026-04-30 | Buy |
| TCI Chemical | M0731 | 5-Methoxyindole >99.0%(GC) | 1006-94-6 | 1g | $57 | 2026-04-30 | Buy |
| TCI Chemical | M0731 | 5-Methoxyindole >99.0%(GC) | 1006-94-6 | 5g | $97 | 2026-04-30 | Buy |
| Usbiological | 234279 | 5-Methoxyindole 99+% (HPLC) ≥99%(HPLC) | 1006-94-6 | 1g | $156 | 2026-06-03 | Buy |
5-Methoxyindole Chemical Properties, Uses, Production
Chemical Properties
white to light brownish crystalline powder
Uses
5-Methoxyindole (cas# 1006-94-6) is a compound useful in organic synthesis. It can be used to synthesis 1-(Phenylsulfonyl)-5-methoxy-1H-indole.
Preparation
The synthesis of 5-methoxyindole from 5-methoxy-2-oxindole: Conversion of 5-methoxy-2-oxindole to 5-methoxyindole was accomplishedby the chlorination of 5-methoxy-2-oxindole with triphenylphosphine-carbontetrachloride in acetonitrile followed by the catalytic reduction of a chlorine atom in 66% total yield.
Definition
ChEBI: 5-methoxyindole is a member of indoles.
Reactions
5-methoxyindole was treated with sodium hydroxide and phenylsulfonyl chloride in the presence of a catalytic amount of tetrabutylammonium bromide to afford 1-(phenylsulfonyl)indole and 5-methoxy-1-(phenylsufonyl)indole in excellent yields of 100%.
Synthesis Reference(s)
Journal of Heterocyclic Chemistry, 26, p. 1405, 1989 DOI: 10.1002/jhet.5570260533
The Journal of Organic Chemistry, 58, p. 5558, 1993 DOI: 10.1021/jo00072a052
Tetrahedron Letters, 27, p. 837, 1986 DOI: 10.1016/S0040-4039(00)84114-3
Synthesis
The synthesis method of 2-pyridinecarboxaldehyde:the three-component coupling reaction of dicarbonyl compounds, aldehydes, and urea/thiourea catalyzed by indium chloride can be efficiently synthesized.
Purification Methods
Crystallise 5-methoxyindole from cyclohexane pet ether or pet ether/Et2O. [Saito & Kikugawa J Heterocycl Chem 16 1325 1979, Beilstein 21 III/IV 765, 21/3 V 18.]
5-Methoxyindole Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Zhanhua Huibang Chemical Co., Ltd. | 13906149256 | 793211102@qq.com | China | 152 | 58 |
| Tongchuang Pharma(Suzhou). Co., Ltd. | 0512-63263366 18912765016 | tongtf110@sina.com | China | 984 | 62 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TAIYUAN RHF CO.,LTD. | +86 351 7031519 | sales@RHFChem.com | China | 2334 | 56 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Beijing dtftchem Technology Co., Ltd. | 010-60275820 13031183356 | elainezt@sina.com | China | 1386 | 62 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
Related articles
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- Jul 27,2026
View Latest Price from 5-Methoxyindole manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-14 | 5-Methoxyindole
1006-94-6
|
$129.00-645.00 | 1g | 0.99 | 25kg | Shanghai UCHEM Inc. | |
 |
2026-05-28 | 5-Methoxyindole
1006-94-6
|
$11.00 | 1ASSAYS | 99% | 10000kg | Hebei Chuanghai Biotechnology Co,.LTD | |
 |
2026-03-20 | 5-METHOXYINDOLE
1006-94-6
|
$10.00 | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd |
-
- 5-Methoxyindole
1006-94-6
- $129.00-645.00
- 0.99
- Shanghai UCHEM Inc.
-
- 5-Methoxyindole
1006-94-6
- $11.00
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
-
- 5-METHOXYINDOLE
1006-94-6
- $10.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
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