5-Methoxy-2,3-dihydroindoline
- CAS No.
- 21857-45-4
- Chemical Name:
- 5-Methoxy-2,3-dihydroindoline
- Synonyms
- 5-Methoxyindoline;5-METHOXYLINDOLINE; 5-Methoxy-2,3-dihydroindolin;5-METHOXY-2,3-DIHYDROINDOLINE;5-METHOXY-2,3-DIHYDRO-1H-INDOLE;1H-INDOLE, 2,3-DIHYDRO-5-METHOXY-;5-Methoxy-2,3-dihydro-1H-indoline;5-Methoxyindoline 5-Methoxy-2,3-dihydroindoline in stock Factory
- CBNumber:
- CB7267569
- Molecular Formula:
- C9H11NO
- Molecular Weight:
- 149.19
- MDL Number:
- MFCD07368037
- MOL File:
- 21857-45-4.mol
- TDS File:
- TDS
| Boiling point | 282.6±29.0 °C(Predicted) |
|---|---|
| Density | 1.076±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| form | solid |
| pka | 6.07±0.20(Predicted) |
| Appearance | Light yellow to brown Liquid |
| InChI | 1S/C9H11NO/c1-11-8-2-3-9-7(6-8)4-5-10-9/h2-3,6,10H,4-5H2,1H3 |
| InChIKey | YYDYAQAVAHKFJO-UHFFFAOYSA-N |
| SMILES | COc1ccc2NCCc2c1 |
| CAS DataBase Reference | 21857-45-4(CAS DataBase Reference) |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H335-H319-H315 |
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 |
| Hazard Codes | T |
| Risk Statements | 25 |
| Safety Statements | 45 |
| WGK Germany | WGK 3 |
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
| Hazard Classifications | Acute Tox. 3 Oral |
5-Methoxy-2,3-dihydroindoline price More Price(52)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 283987 | 5-Methoxy-2,3-dihydro-1H-indole hydrochloride Asreported | 21857-45-4 | 250mg | $368 | 2026-06-03 | Buy |
| Usbiological | 283987 | 5-Methoxy-2,3-dihydro-1H-indole hydrochloride Asreported | 21857-45-4 | 500mg | $509 | 2026-06-03 | Buy |
| Usbiological | 283987 | 5-Methoxy-2,3-dihydro-1H-indole hydrochloride Asreported | 21857-45-4 | 1g | $831 | 2026-06-03 | Buy |
| Usbiological | 283987 | 5-Methoxy-2,3-dihydro-1H-indole hydrochloride Asreported | 21857-45-4 | 2g | $1165 | 2026-06-03 | Buy |
| Usbiological | 283987 | 5-Methoxy-2,3-dihydro-1H-indole hydrochloride Asreported | 21857-45-4 | 5g | $1416 | 2026-06-03 | Buy |
5-Methoxy-2,3-dihydroindoline Chemical Properties, Uses, Production
Synthesis
1006-94-6
21857-45-4
5-Methoxyindole (1.5 g, 10.2 mmol) was dissolved in acetic acid (20 mL) at 25 °C, followed by the addition of sodium cyanoborohydride (0.77 g, 12.2 mmol) in batches. After the reaction lasted for 1 h, the pH of the reaction solution was adjusted to 9-10 with 20% sodium hydroxide solution for neutralization. The reaction mixture was extracted with ethyl acetate (50 mL) and the organic phase was separated and dried over anhydrous sodium sulfate. The dried organic phase was filtered and the filtrate was concentrated by rotary evaporation. Finally, 5-methoxyindoline was purified by column chromatography (eluent: petroleum ether/ethyl acetate, 10:1, v/v) to afford 5-methoxyindoline as a brown solid (1.46 g, 95.9% yield).
References
[1] Organic Letters, 2011, vol. 13, # 19, p. 5124 - 5127
[2] Chemical Communications, 2013, vol. 49, # 63, p. 7052 - 7054
[3] Patent: CN105367474, 2016, A. Location in patent: Paragraph 0194; 0195; 0196; 0197
[4] Journal of Medicinal Chemistry, 1997, vol. 40, # 4, p. 479 - 485
[5] Patent: EP1223170, 2002, A1
5-Methoxy-2,3-dihydroindoline Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| China DongFan Chemical Co.,LTD | 86-0571-85151182 | China | 5681 | 66 | |
| Nanjing Vital Chemical Co., Ltd. | Please Send Email 18652950785 | chemweiao@163.com | China | 4368 | 65 |
| Changzhou Wanyao Biotechnology Co., Ltd. | 0519-89185693 15312551983 | 2410037592@qq.com | China | 278 | 55 |
| Wuhan Haizheng Industry & Trade Development Co. Ltd | 027-8866 0053/88660577/88660578 | China | 1070 | 55 | |
| Shanghai Xiannuo Biotechnology Co., Ltd. | 021-50718719 13918719472 | China | 978 | 58 |
View Latest Price from 5-Methoxy-2,3-dihydroindoline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-25 | 5-Methoxyindoline
21857-45-4
|
$1.10-9.90 | 1KG | 99% min | 100kg | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |
 |
2020-06-02 | 5-Methoxyindoline 5-Methoxy-2,3-dihydroindoline in stock Factory
21857-45-4
|
$1.00 | 1KG | TOP 3 Factory in China | Chemwill Asia Co.,Ltd. | ||
 |
2019-07-06 | 5-Methoxy-2,3-dihydroindoline
21857-45-4
|
$8.00 | 1kg | 99% | 10tons | Career Henan Chemical Co |
-
- 5-Methoxyindoline
21857-45-4
- $1.10-9.90
- 99% min
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- 5-Methoxyindoline 5-Methoxy-2,3-dihydroindoline in stock Factory
21857-45-4
- $1.00
- TOP 3 Factory in China
- Chemwill Asia Co.,Ltd.
-
- 5-Methoxy-2,3-dihydroindoline
21857-45-4
- $8.00
- 99%
- Career Henan Chemical Co
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