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(R)-(+)-2-Piperazinecarboxylic acid dihydrochloride

(R)-(+)-2-Piperazinecarboxylic acid dihydrochloride structure

CAS No.: 126330-90-3

Chemical Name:: (R)-(+)-2-Piperazinecarboxylic acid dihydrochloride

Synonyms: (R)-PIPERAZINE-2-CARBOXYLIC ACID DIHYDROCHLORIDE;(R)-(+)-2-Piperazine;(R)-Piperazine-2-carboxyl...;(R)-Piperazin-2-carbonsaeure2HCl;3-PIPERAZINE CARBOXYLIC ACID HCL;2-(R)-Piperazine carboxylic acid 2HCl;(R)-PIPERAZINE-2-CARBOXYLIC ACID 2HCL;(S)-PIPERAZINE-2-CARBOXYLIC ACID 2HCL;(2R)-2-Piperazinecarboxylic acid 2HCl;(R)-(+)-PIPERAZINE-2-CARBOXYLIC ACID DIHCL

CBNumber:: CB4224459

Molecular Formula:: C5H12Cl2N2O2

Molecular Weight:: 203.07

MDL Number:: MFCD03840829

MOL File:: 126330-90-3.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 02:32:17

Product description	Number	Pack Size	Price
(R)-2-Piperazinecarboxylic acid dihydrochloride ≥98.0%	67176	1g	$40.6
(R)-2-Piperazinecarboxylic acid dihydrochloride ≥98.0%	67176	5g	$98.8
(R)-(+)-PipeRazine-2-carboxylic acid 2HCl Asreported	287653	1g	$319
(R)-(+)-PipeRazine-2-carboxylic acid 2HCl Asreported	287653	2g	$418
(R)-(+)-PipeRazine-2-carboxylic acid 2HCl Asreported	287653	5g	$552
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(R)-(+)-2-Piperazinecarboxylic acid dihydrochloride Properties

Melting point	ca 265℃
Flash point	143.5℃
storage temp.	Inert atmosphere,Room Temperature
form	solid
Appearance	White to off-white Solid
optical activity	[α]20/D +5±1°, c = 1% in H2O
InChI	InChI=1/C5H10N2O2.2ClH/c8-5(9)4-3-6-1-2-7-4;;/h4,6-7H,1-3H2,(H,8,9);2*1H/t4-;;/s3
InChIKey	WNSDZBQLMGKPQS-RZFWHQLPSA-N
SMILES	[C@H]1(C(=O)O)NCCNC1.Cl.Cl \|&1:0,r\|
CAS DataBase Reference	126330-90-3(CAS DataBase Reference)
UNSPSC Code	12352005
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P305+P351+P338-P280a-P304+P340-P405-P501a

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

3-10

HS Code

29335990

Storage Class

13 - Non Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	0
2		0

(R)-(+)-2-Piperazinecarboxylic acid dihydrochloride price More Price(62)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	67176	(R)-2-Piperazinecarboxylic acid dihydrochloride ≥98.0%	126330-90-3	1g	$40.6	2022-05-15	Buy
Sigma-Aldrich	67176	(R)-2-Piperazinecarboxylic acid dihydrochloride ≥98.0%	126330-90-3	5g	$98.8	2022-05-15	Buy
Usbiological	287653	(R)-(+)-PipeRazine-2-carboxylic acid 2HCl Asreported	126330-90-3	1g	$319	2026-06-03	Buy
Usbiological	287653	(R)-(+)-PipeRazine-2-carboxylic acid 2HCl Asreported	126330-90-3	2g	$418	2026-06-03	Buy
Usbiological	287653	(R)-(+)-PipeRazine-2-carboxylic acid 2HCl Asreported	126330-90-3	5g	$552	2026-06-03	Buy

Product number	Packaging	Price	Buy
67176	1g	$40.6	Buy
67176	5g	$98.8	Buy
287653	1g	$319	Buy
287653	2g	$418	Buy
287653	5g	$552	Buy

(R)-(+)-2-Piperazinecarboxylic acid dihydrochloride Chemical Properties,Uses,Production

Chemical Properties

White solid

Uses

(R)-2-Piperazinecarboxylic acid dihydrochloride can be used as a starting material for the synthesis of (R)-enantiomers of anthramycin analogs, which are potential antiproliferative agents. It can also be employed in the preparation of piperazinemethanol chiral ligands, which can be utilized in the enantioselective borane reduction of aromatic ketones, ketimine, and oxime ether.

Synthesis

As a method for the preparation of racemic 2-piperazine carboxylic acids by optical splitting, it is known to use cyclic camphorsulfonic acid as a splitting agent, racemic 2-piperazine carboxylic acids and cyclic camphorsulfonic acid are made to be dissolved in a solvent and the resultant solution is treated with activated charcoal to remove the color, after which (R)-piperazine-2-carboxylic acid dihydrochloride is precipitated.

(R)-(+)-2-Piperazinecarboxylic acid dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

(R)-4-Boc-Piperazine-3-carboxylic acid

(R)-(+)-2-Piperazinecarboxylic acid dihydrochloride Suppliers

Global( 223)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21533	55
Chembon Pharmaceutical Co., Ltd.	+86-28-8425-2981		CHINA	722	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3004	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29766	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10399	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8491	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63645	58
CONIER CHEM AND PHARMA LIMITED		sales@conier.com	China	49906	58
Antai Fine Chemical Technology Co.,Limited	18503026267	info@antaichem.com	CHINA	9631	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21135	58

Supplier	Advantage
Henan Tianfu Chemical Co.,Ltd.	55
Chembon Pharmaceutical Co., Ltd.	55
Nanjing ChemLin Chemical Industry Co., Ltd.	60
career henan chemical co	58
Shenzhen Nexconn Pharmatechs Ltd	58
Jinan Carbotang Biotech Co.,Ltd.	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Antai Fine Chemical Technology Co.,Limited	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58

View Lastest Price from (R)-(+)-2-Piperazinecarboxylic acid dihydrochloride manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-11-18	(R)-(+)-2-Piperazinecarboxylic acid dihydrochloride 126330-90-3	$1.10	1g	99.00%	100 Tons	Dideu Industries Group Limited
	2019-07-06	(R)-(+)-2-Piperazinecarboxylic acid dihydrochloride 126330-90-3	$1.00	1KG	98%-100%	1	Career Henan Chemical Co

(R)-(+)-2-Piperazinecarboxylic acid dihydrochloride
126330-90-3
$1.10
99.00%
Dideu Industries Group Limited

(R)-(+)-2-Piperazinecarboxylic acid dihydrochloride
126330-90-3
$1.00
98%-100%
Career Henan Chemical Co

(R)-(+)-2-Piperazinecarboxylic acid dihydrochloride Spectrum

(R)-(+)-2-Piperazinecarboxylic acid dihydrochloride(126330-90-3)¹HNMR

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(S)-(-)-2-PIPERAZINECARBOXYLIC ACID DIHYDROCHLORIDE (R)-PIPERAZINE-2-CARBOXYLIC ACID 2HCL (R)-(+)-PIPERAZINE-2-CARBOXYLIC ACID DIHYDROCHLORIDE (R)-PIPERAZINE-2-CARBOXYLIC ACID DIHYDROCHLORIDE 2-(R)-Piperazine carboxylic acid 2HCl (R)-(+)-2-Piperazine (2R)-(+)-Piperazine-2-carboxylic acid dihydrochloride (R)-Piperazine-2-carboxyl... D,L-piperazine-2-carboxylic acid dihydrochloride (S)-PIPERAZINE-2-CARBOXYLIC ACID 2HCL (R)-(+)-2-PIPERAZINECARBOXYLIC ACID DIHYDROCHLORIDE (R)-2-PIPERAZINECARBOXYLIC ACID DIHYDROCHLORIDE PIPERAZINECARBOXYLIC ACID, (R)-, DIHYDROCHLORIDE 2-PIPERAZINECARBOXYLIC ACID, (S)-, DIHYDROCHLORIDE 2-PIPERAZINECARBOXYLIC ACID, DIHYDROCHLORIDE, (2R)- 2-PIPERAZINECARBOXYLIC ACID, DIHYDROCHLORIDE, (2S)- (r)-piperazine-2-carbxylicaciddihydrochloride (R)-(+)-PIPERAZINE-2-CARBOXYLIC ACID DIHCL (R)-Piperazin-2-carbonsaeure2HCl (R)-(+)-PIPERAZINE-2-CARBOXYLIC ACID DIHYDROCHLORIDE,98% 3-PIPERAZINE CARBOXYLIC ACID HCL (S)-1-(5-hydroxy-2-(2-hydroxy-3-(tert-pentylamino)propoxy)phenyl)-3-phenylpropan-1-one 2-Piperazinecarboxylic acid, hydrochloride (1:2), (2R)- (R)-(+)-2-Piperazinecarboxylic acid dihydrochloride ISO 9001：2015 REACH (2R)-2-Piperazinecarboxylic acid hydrochloride (1:2) (2R)-2-Piperazinecarboxylic acid 2HCl (R)-2-Piperazinecarboxylic acid dihydrochloride (2R)-2-Piperazine carboxylic acid dihydrochloride, 98%min 126330-90-3 138663-69-5 C6H14N2O22HCl C5H10N2O2x2HCl Peptide Synthesis Others Specialty Synthesis Unnatural Amino Acid Derivatives amino acids Chiral Building Blocks Heterocyclic Building Blocks API intermediates Piperazines Piperazine series chiral Amino acids, non natural Chiral Compounds