5-Iodo-3-(trifluoromethyl)-2(1H)-pyridinone
- CAS No.
- 887707-23-5
- Chemical Name:
- 5-Iodo-3-(trifluoromethyl)-2(1H)-pyridinone
- Synonyms
- 5-Iodo-3-(trifluoromethyl)-2-pyridino;5-iodo-3-(trifluoromethyl)pyridin-2-ol;3-(trifluoromethyl)-5-iodopyridin-2-ol;5-Iodo-3-trifluoroMethyl-1H-pyridin-2-one;5-Iodo-3-(trifluoromethyl)-2(1H)-yridinone;5-iodo-3-(trifluoroMethyl)pyridin-2(1H)-one;5-Iodo-3-(trifluoromethyl)-2(1H)-pyridinone;5-Iodo-2-hydroxy-3-(trifluoroMethyl)pyridine;2-Hydroxy-5-Iodo-3-(trifluoromethyl)pyridine;2(1H)-Pyridinone, 5-iodo-3-(trifluoromethyl)-
- CBNumber:
- CB42449645
- Molecular Formula:
- C6H3F3INO
- Molecular Weight:
- 288.99
- MDL Number:
- MFCD12024303
- MOL File:
- 887707-23-5.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HazardClass | IRRITANT |
| HS Code | 2933399990 |
5-Iodo-3-(trifluoromethyl)-2(1H)-pyridinone price More Price(35)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | PC56189 | 2-Hydroxy-5-iodo-3-(trifluoromethyl)pyridine 95% | 887707-23-5 | 1g | $22 | 2026-06-04 | Buy |
| Apolloscientific | PC56189 | 2-Hydroxy-5-iodo-3-(trifluoromethyl)pyridine 95% | 887707-23-5 | 5g | $44 | 2026-06-04 | Buy |
| Apolloscientific | PC56189 | 2-Hydroxy-5-iodo-3-(trifluoromethyl)pyridine 95% | 887707-23-5 | 25g | $204 | 2026-06-04 | Buy |
| Matrix Scientific | 143900 | 5-Iodo-3-(trifluoromethyl)pyridin-2(1H)-one | 887707-23-5 | 5.00g | $1203 | 2026-05-18 | Buy |
| Matrix Scientific | 143900 | 5-Iodo-3-(trifluoromethyl)pyridin-2(1H)-one | 887707-23-5 | 10.00g | $2036 | 2026-05-18 | Buy |
5-Iodo-3-(trifluoromethyl)-2(1H)-pyridinone Chemical Properties, Uses, Production
Synthesis
22245-83-6
887707-23-5
General procedure for the synthesis of 2-hydroxy-5-iodo-3-(trifluoromethyl)pyridine from 2-hydroxy-3-trifluoromethylpyridine: 1. 3-Trifluoromethyl-2-pyridinol (25 g, 153.3 mmol) was dissolved in a mixed solvent of anhydrous acetonitrile (150 mL) and N,N-dimethylformamide (150 mL). 2. N-iodosuccinimide (34.5 g, 153 mmol) was added to the above solution. 3. The reaction mixture was stirred at 80 °C for 2 hours and subsequently cooled to room temperature. 4. 1 M aqueous sodium bicarbonate (150 mL) was added to the cooled reaction mixture and stirred for 5 minutes. 5. The mixed solvents were evaporated to dryness, an appropriate amount of water was added and the aqueous phase was extracted twice with dichloromethane. 6. The organic phases were combined and evaporated, and the resulting crude product was recrystallized in water to give 36.2 g (81% yield) of a white powdery target product, 2-hydroxy-5-iodo-3-(trifluoromethyl)pyridine. Product characterization data: 1H NMR (500 MHz, CDCl3) δ 7.85 (d, J = 2.3 Hz, 1H), 7.98 (d, J = 2.3 Hz, 1H), 13.41 (br s, 1H). 13C NMR (250 MHz, CDCl3) δ 63.0, 121.4 (q, JC-F = 272.3 Hz), 122.2 (q, JC-F = 31.6 Hz), 144.4, 148.1 (q, JC-F = 5.0 Hz), 160.1.
References
[1] Organic Process Research and Development, 2013, vol. 17, # 12, p. 1561 - 1567
[2] Patent: WO2008/119015, 2008, A2. Location in patent: Page/Page column 48
[3] Patent: JP2016/11315, 2016, A. Location in patent: Paragraph 0084
[4] Patent: US9388159, 2016, B2. Location in patent: Page/Page column 19; 20; 21
[5] Patent: WO2015/100613, 2015, A1. Location in patent: Page/Page column 17
5-Iodo-3-(trifluoromethyl)-2(1H)-pyridinone Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Shanghai Cuisen Pharmaceutical Technology Co., Ltd. | 13472757003 | yongnan.wang@cendrix.cn | China | 971 | 65 |
| Chiba Pharmaceutical Science and technology Co, Ltd. | 0531-81313138 13066006660 | chibapharm@foxmail.com | China | 3996 | 55 |
| Shanghai T&W Pharmaceutical Co., Ltd. | +86 21 61551611 | China | 9874 | 58 | |
| SuZhou ShiYa Biopharmaceuticals, Inc. | 86(512)5235 8471 17715136450 | sales@shiyabiopharm.com | China | 4167 | 58 |
| SynAsst Chemical. | 021-60343070 | China | 12731 | 55 | |
| Shanghai Witofly Chemical Co.,Ltd | sales@witofly.com | China | 2853 | 52 | |
| Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd. | +86-28-85122536 85324413 | market@astatech.cn | China | 8016 | 55 |
View Latest Price from 5-Iodo-3-(trifluoromethyl)-2(1H)-pyridinone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | 5-IODO-3-(TRIFLUOROMETHYL)-2(1H)-PYRIDINONE
887707-23-5
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2019-12-20 | 5-IODO-3-(TRIFLUOROMETHYL)-2(1H)-PYRIDINONE
887707-23-5
|
$1.00 | 1g | 99% | 1000KGS | Career Henan Chemical Co |
-
- 5-IODO-3-(TRIFLUOROMETHYL)-2(1H)-PYRIDINONE
887707-23-5
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 5-IODO-3-(TRIFLUOROMETHYL)-2(1H)-PYRIDINONE
887707-23-5
- $1.00
- 99%
- Career Henan Chemical Co
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