ChemicalBook >> CAS DataBase List >>5,6-DIMETHYL-2-OXO-1,2-DIHYDRO-PYRIDINE-3-CARBONITRILE

5,6-DIMETHYL-2-OXO-1,2-DIHYDRO-PYRIDINE-3-CARBONITRILE

5,6-DIMETHYL-2-OXO-1,2-DIHYDRO-PYRIDINE-3-CARBONITRILE structure

CAS No.: 72716-80-4

Chemical Name:: 5,6-DIMETHYL-2-OXO-1,2-DIHYDRO-PYRIDINE-3-CARBONITRILE

Synonyms: 3-Pyridinecarbonitrile, 1,2-dihydro-5,6-diMethyl-2-oxo-;104166;3-Cyano-5,6-diMethylpyrid-2-one;3-Cyano-5,6-diMethylpyridin-2-ol;2-Hydroxy-5,6-dimethylnicotinonitrile;2-Hydroxy-3-cyano-5,6-diMethylpyridine;2-Hydroxy-5,6-dimethyl-3-pyridinecarbonitrile;2-HYDROXY-5,6-DIMETHYLPYRIDINE-3-CARBONITRILE;1,2-dihydro-5,6-diMethyl-2-oxo-3-Pyridinecarbonitrile;1,2-dihydro-5,6-dimethyl-2-oxopyridine-3-carbonitrile

CBNumber:: CB7837201

Molecular Formula:: C8H8N2O

Molecular Weight:: 148.16

MDL Number:: MFCD03004855

MOL File:: 72716-80-4.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:51

Product description	Number	Pack Size	Price
2-Hydroxy-5,6-dimethyl-3-pyridinecarbonitrile	H825240	2g	$245
2-Hydroxy-5,6-dimethyl-3-pyridinecarbonitrile	279341	1g	$460
5,6-DIMETHYL-2-OXO-1,2-DIHYDRO-PYRIDINE-3-CARBONITRILE 95.00%	CHM0299000	5MG	$500.94
5,6-Dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile 95%	069698	500mg	$341
5,6-Dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile	CS-0038492	5g	$345
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5,6-DIMETHYL-2-OXO-1,2-DIHYDRO-PYRIDINE-3-CARBONITRILE Properties

Melting point	270 °C
Boiling point	335.6±35.0 °C(Predicted)
Density	1.16±0.1 g/cm3(Predicted)
storage temp.	Inert atmosphere,Room Temperature
solubility	Acetic Acid, DMSO
pka	9.44±0.10(Predicted)
Appearance	White to yellow Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H332-H335
Precautionary statements	P280-P305+P351+P338-P310
HS Code	2933399990

5,6-DIMETHYL-2-OXO-1,2-DIHYDRO-PYRIDINE-3-CARBONITRILE price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	H825240	2-Hydroxy-5,6-dimethyl-3-pyridinecarbonitrile	72716-80-4	2g	$245	2021-12-16	Buy
Usbiological	279341	2-Hydroxy-5,6-dimethyl-3-pyridinecarbonitrile	72716-80-4	1g	$460	2021-12-16	Buy
American Custom Chemicals Corporation	CHM0299000	5,6-DIMETHYL-2-OXO-1,2-DIHYDRO-PYRIDINE-3-CARBONITRILE 95.00%	72716-80-4	5MG	$500.94	2021-12-16	Buy
Matrix Scientific	069698	5,6-Dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile 95%	72716-80-4	500mg	$341	2021-12-16	Buy
ChemScene	CS-0038492	5,6-Dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile	72716-80-4	5g	$345	2021-12-16	Buy

Product number	Packaging	Price	Buy
H825240	2g	$245	Buy
279341	1g	$460	Buy
CHM0299000	5MG	$500.94	Buy
069698	500mg	$341	Buy
CS-0038492	5g	$345	Buy

5,6-DIMETHYL-2-OXO-1,2-DIHYDRO-PYRIDINE-3-CARBONITRILE Chemical Properties,Uses,Production

Uses

An intermediate in the preparation of HIV-1 specific reverse transcriptase inhibitors, antiallergic agents, and Omeprazole metabolites.

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 24, p. 351, 1987 DOI: 10.1002/jhet.5570240211

Synthesis

3-Buten-2-one, 4-hydroxy-3-methyl-, sodium salt (1:1)

143193-92-4

107-91-5

5,6-DIMETHYL-2-OXO-1,2-DIHYDRO-PYRIDINE-3-CARBONITRILE

72716-80-4

The general procedure for the synthesis of 2-hydroxy-3-cyano-5,6-dimethylpyridine from the compound (CAS:143193-92-4) and cyanoacetamide was as follows: sodium (E/Z)-2-methyl-3-oxo-1-en-1-ol (77.6 g, 0.64 mol) was added to 480 mL of water, followed by the addition of cyanoacetamide (49.0 g, 0.70 mol). To the mixture was added a piperidine-acetic acid solution prepared from acetic acid (9.16 g, 8.75 mL, 0.15 mol), 21.2 mL of water and pyridine (13.0 g, 15.1 mL, 0.15 mol). The mixture was heated at reflux for 4 hours and then stirred at room temperature for 16 hours. Upon completion of the reaction, acetic acid (75.5 g, 72 mL, 1.26 mol) was added to the reaction mixture, prompting the precipitation of a pale yellow solid. The precipitate was collected by diafiltration, washed with water and dried under reduced pressure at 55 °C for 2 hours. A final 66.4 g (70% of theoretical yield) of light yellow solid product was obtained.

References

[1] Patent: CN105530814, 2016, A. Location in patent: Paragraph 0328; 0329; 0330
[2] Journal of Heterocyclic Chemistry, 1987, vol. 24, p. 351 - 355

5,6-DIMETHYL-2-OXO-1,2-DIHYDRO-PYRIDINE-3-CARBONITRILE Preparation Products And Raw materials

Raw materials

3-Buten-2-one, 4-hydroxy-3-methyl-, sodium salt (1:1) 2-Butanone 2-Cyanoacetamide Ethyl formate Acetic acid

Pyridine Piperidine

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Preparation Products

2-CHLORO-5,6-DIMETHYL-3-PYRIDINCARBONITRILE

5,6-DIMETHYL-2-OXO-1,2-DIHYDRO-PYRIDINE-3-CARBONITRILE Suppliers

Global( 92)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	+86-13017695106 +86-13676922317	jiuyitime@fdachem.com	China	16513	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29795	58
Fuxin Pharmaceutical	+86-021-021-50872116 +8613122107989	contact@fuxinpharm.com	China	10000	58
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	eric@witopchemical.com	China	23541	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	1026@dideu.com	China	7099	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 +8617705817739	info@dycnchem.com	China	52846	58

Supplier	Advantage
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	58
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
Hubei xin bonus chemical co. LTD	58
Alchem Pharmtech,Inc.	58
career henan chemical co	58
Fuxin Pharmaceutical	58
ANHUI WITOP BIOTECH CO., LTD	58
Shaanxi Dideu Medichem Co. Ltd	58
Dayang Chem (Hangzhou) Co.,Ltd.	58

View Lastest Price from 5,6-DIMETHYL-2-OXO-1,2-DIHYDRO-PYRIDINE-3-CARBONITRILE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-10-13	2-Hydroxy-5,6-dimethyl-3-pyridinecarbonitrile 72716-80-4	US $1.60-9.60 / kg	1kg	99%	100kg	ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
2025-06-25	5,6-DIMETHYL-2-OXO-1,2-DIHYDRO-PYRIDINE-3-CARBONITRILE 72716-80-4	US $1.10 / g	1g	99.0% min	100 tons min	Shaanxi Dideu Medichem Co. Ltd
2019-12-25	5,6-DIMETHYL-2-OXO-1,2-DIHYDRO-PYRIDINE-3-CARBONITRILE 72716-80-4	US $9.80 / KG	1g	≥99%	100kg	Career Henan Chemical Co

2-Hydroxy-5,6-dimethyl-3-pyridinecarbonitrile
72716-80-4
US $1.60-9.60 / kg
99%
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

5,6-DIMETHYL-2-OXO-1,2-DIHYDRO-PYRIDINE-3-CARBONITRILE
72716-80-4
US $1.10 / g
99.0% min
Shaanxi Dideu Medichem Co. Ltd

5,6-DIMETHYL-2-OXO-1,2-DIHYDRO-PYRIDINE-3-CARBONITRILE
72716-80-4
US $9.80 / KG
≥99%
Career Henan Chemical Co

5,6-DIMETHYL-2-OXO-1,2-DIHYDRO-PYRIDINE-3-CARBONITRILE Spectrum

5,6-DIMETHYL-2-OXO-1,2-DIHYDRO-PYRIDINE-3-CARBONITRILE(72716-80-4)¹HNMR

72716-80-4(5,6-DIMETHYL-2-OXO-1,2-DIHYDRO-PYRIDINE-3-CARBONITRILE)Related Search:

2-Hydroxy-4-methyl-6-(trifluoromethyl)-pyridine 5-IODO-3-(TRIFLUOROMETHYL)-2(1H)-PYRIDINONE 5,6-DIMETHYL-2-OXO-1,2-DIHYDRO-PYRIDINE-3-CARBONITRILE Saterinone Milrinone lactate

Olprinone Milrinone 3-Cyano-4,6-dimethyl-2-hydroxypyridine 2-HYDROXY-4,5,6-TRIMETHYLNICOTINONITRILE 2-OXO-1,2,5,6,7,8-HEXAHYDRO-3-QUINOLINECARBONITRILE

5-ACETYL-6-METHYL-2-OXO-1,2-DIHYDROPYRIDINE-3-CARBONITRILE 6-BROMO-2,5-DIOXO-1,2,5,6,7,8-HEXAHYDROQUINOLINE-3-CARBONITRILE METHYL 5-CYANO-6-HYDROXY-2-METHYLNICOTINATE 1-AMINO-4,6-DIMETHYL-2-OXO-1,2-DIHYDRO-PYRIDINE-3-CARBONITRILE BUTTPARK 17\04-65

METHYL 5-CYANO-2-METHYL-6-PHENOXYNICOTINATE BUTTPARK 17\04-61 2-HYDROXY-5-(QUINOXALIN-2-YL)-6-(PYRIDIN-4-YL)-3-PYRIDINECARBONITRILE

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104166 5,6-DIMETHYL-2-OXO-1,2-DIHYDRO-PYRIDINE-3-CARBONITRILE 5,6-Dimethyl-2-oxo-1,2-dihydro-3-pyridinecarbonitrile 2-Hydroxy-5,6-dimethylnicotinonitrile 1,2-dihydro-5,6-dimethyl-2-oxopyridine-3-carbonitrile 2-Hydroxy-5,6-dimethyl-3-pyridinecarbonitrile 3-Pyridinecarbonitrile,1,2-dihydro-5,6-dimethyl-2-oxo-(9CI) 2-HYDROXY-5,6-DIMETHYLPYRIDINE-3-CARBONITRILE 1,2-dihydro-5,6-diMethyl-2-oxo-3-Pyridinecarbonitrile 2-Hydroxy-3-cyano-5,6-diMethylpyridine 3-Cyano-5,6-diMethylpyrid-2-one 3-Cyano-5,6-diMethylpyridin-2-ol 3-Pyridinecarbonitrile, 1,2-dihydro-5,6-diMethyl-2-oxo- 5,6-DIMETHYL-2-OXO-1,2-DIHYDRO-PYRIDINE-3-CARBONITRILE ISO 9001：2015 REACH 72716-80-4 NITRILE Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals