5,6-Dimethyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile
- CAS No.
- 72716-80-4
- Chemical Name:
- 5,6-Dimethyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile
- Synonyms
- 3-Pyridinecarbonitrile, 1,2-dihydro-5,6-diMethyl-2-oxo-;104166;3-Cyano-5,6-diMethylpyrid-2-one;3-Cyano-5,6-diMethylpyridin-2-ol;2-Hydroxy-5,6-dimethylnicotinonitrile;2-Hydroxy-3-cyano-5,6-diMethylpyridine;2-HYDROXY-5,6-DIMETHYLPYRIDINE-3-CARBONITRILE;2-Hydroxy-5,6-dimethyl-3-pyridinecarbonitrile;1,2-dihydro-5,6-dimethyl-2-oxopyridine-3-carbonitrile;5,6-Dimethyl-2-oxo-1,2-dihydro-3-pyridinecarbonitrile
- CBNumber:
- CB7837201
- Molecular Formula:
- C8H8N2O
- Molecular Weight:
- 148.16
- MDL Number:
- MFCD03004855
- MOL File:
- 72716-80-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P280-P305+P351+P338-P310 |
| HS Code | 2933399990 |
5,6-Dimethyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 279341 | 2-Hydroxy-5,6-dimethyl-3-pyridinecarbonitrile | 72716-80-4 | 1g | $460 | 2026-06-03 | Buy |
| Usbiological | 279341 | 2-Hydroxy-5,6-dimethyl-3-pyridinecarbonitrile | 72716-80-4 | 2g | $705 | 2026-06-03 | Buy |
| Usbiological | 279341 | 2-Hydroxy-5,6-dimethyl-3-pyridinecarbonitrile | 72716-80-4 | 5g | $1091 | 2026-06-03 | Buy |
| Usbiological | 279341 | 2-Hydroxy-5,6-dimethyl-3-pyridinecarbonitrile | 72716-80-4 | 10g | $1736 | 2026-06-03 | Buy |
| Usbiological | 279341 | 2-Hydroxy-5,6-dimethyl-3-pyridinecarbonitrile | 72716-80-4 | 25g | $2850 | 2026-06-03 | Buy |
5,6-Dimethyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile Chemical Properties, Uses, Production
Uses
An intermediate in the preparation of HIV-1 specific reverse transcriptase inhibitors, antiallergic agents, and Omeprazole metabolites.
Synthesis Reference(s)
Journal of Heterocyclic Chemistry, 24, p. 351, 1987 DOI: 10.1002/jhet.5570240211
Synthesis
143193-92-4
107-91-5
72716-80-4
The general procedure for the synthesis of 2-hydroxy-3-cyano-5,6-dimethylpyridine from the compound (CAS:143193-92-4) and cyanoacetamide was as follows: sodium (E/Z)-2-methyl-3-oxo-1-en-1-ol (77.6 g, 0.64 mol) was added to 480 mL of water, followed by the addition of cyanoacetamide (49.0 g, 0.70 mol). To the mixture was added a piperidine-acetic acid solution prepared from acetic acid (9.16 g, 8.75 mL, 0.15 mol), 21.2 mL of water and pyridine (13.0 g, 15.1 mL, 0.15 mol). The mixture was heated at reflux for 4 hours and then stirred at room temperature for 16 hours. Upon completion of the reaction, acetic acid (75.5 g, 72 mL, 1.26 mol) was added to the reaction mixture, prompting the precipitation of a pale yellow solid. The precipitate was collected by diafiltration, washed with water and dried under reduced pressure at 55 °C for 2 hours. A final 66.4 g (70% of theoretical yield) of light yellow solid product was obtained.
References
[1] Patent: CN105530814, 2016, A. Location in patent: Paragraph 0328; 0329; 0330
[2] Journal of Heterocyclic Chemistry, 1987, vol. 24, p. 351 - 355
5,6-Dimethyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Carbott PharmTech Inc. | 0535-6385396 | info@carbottpharm.com | China | 996 | 56 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@163.com | China | 280 | 58 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Beijing HengPuGao Pharmaceutical Chemistry Technology Co., Ltd. | 010-81520996 13439320863 | hengpugao@126.com | China | 159 | 57 |
| ChemShuttle, Inc. | 0510-83588313-811 18800520310 | sales@chemshuttle.com | China | 2999 | 62 |
| Chiba Pharmaceutical Science and technology Co, Ltd. | 0531-81313138 13066006660 | chibapharm@foxmail.com | China | 3996 | 55 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29985 | 65 |
| shanghai cooperpharm co.,LTD . | +86-021-58975553 | sales@cooperpharm.com | China | 1210 | 56 |
| Anichem Inc. | 0512-69369885 | sales@anichem.com.cn | China | 493 | 55 |
View Latest Price from 5,6-Dimethyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-25 | 2-Hydroxy-5,6-dimethyl-3-pyridinecarbonitrile
72716-80-4
|
$1.60-9.60 | 1kg | 99% | 100kg | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |
 |
2025-06-25 | 5,6-DIMETHYL-2-OXO-1,2-DIHYDRO-PYRIDINE-3-CARBONITRILE
72716-80-4
|
$1.10 | 1g | 99.0% min | 100 tons min | Shaanxi Dideu Medichem Co. Ltd | |
 |
2019-12-25 | 5,6-DIMETHYL-2-OXO-1,2-DIHYDRO-PYRIDINE-3-CARBONITRILE
72716-80-4
|
$9.80 | 1g | ≥99% | 100kg | Career Henan Chemical Co |
-
- 2-Hydroxy-5,6-dimethyl-3-pyridinecarbonitrile
72716-80-4
- $1.60-9.60
- 99%
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- 5,6-DIMETHYL-2-OXO-1,2-DIHYDRO-PYRIDINE-3-CARBONITRILE
72716-80-4
- $1.10
- 99.0% min
- Shaanxi Dideu Medichem Co. Ltd
-
- 5,6-DIMETHYL-2-OXO-1,2-DIHYDRO-PYRIDINE-3-CARBONITRILE
72716-80-4
- $9.80
- ≥99%
- Career Henan Chemical Co
72716-80-4 (5,6-Dimethyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile) Related Search:
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