2-Chloro-5-nitro-3-(trifluoromethyl)pyridine
- CAS No.
- 99368-67-9
- Chemical Name:
- 2-Chloro-5-nitro-3-(trifluoromethyl)pyridine
- Synonyms
- C90145;2-Chloro-3-trifluoromethyl-5-nitropyridine;2-Chloro-5-nitro-3-(trifluoromethyl)pyridine;Pyridine, 2-chloro-5-nitro-3-(trifluoromethyl)-;2-CHLORO-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE ISO 9001：2015 REACH
- CBNumber:
- CB2421144
- Molecular Formula:
- C6H2ClF3N2O2
- Molecular Weight:
- 226.54
- MDL Number:
- MFCD00792435
- MOL File:
- Mol file
- MSDS File:
- SDS
| Boiling point | 249℃ |
|---|---|
| Density | 1.618 |
| Flash point | 105℃ |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | solid |
| pka | -6.04±0.10(Predicted) |
| Appearance | Light yellow to yellow Liquid |
| InChI | InChI=1S/C6H2ClF3N2O2/c7-5-4(6(8,9)10)1-3(2-11-5)12(13)14/h1-2H |
| InChIKey | OPEZLLCPUDLUFV-UHFFFAOYSA-N |
| SMILES | C1(Cl)=NC=C([N+]([O-])=O)C=C1C(F)(F)F |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302+H312+H332-H315-H319-H335 |
| Precautionary statements | P260-P301+P312-P280 |
| RIDADR | 2810 |
| HazardClass | 6.1 |
| PackingGroup | Ⅲ |
| HS Code | 2933399990 |
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
2-Chloro-5-nitro-3-(trifluoromethyl)pyridine price More Price(51)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | PC56251 | 2-Chloro-5-nitro-3-(trifluoromethyl)pyridine >98% | 99368-67-9 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC56251 | 2-Chloro-5-nitro-3-(trifluoromethyl)pyridine >98% | 99368-67-9 | 5g | $35 | 2026-06-04 | Buy |
| Apolloscientific | PC56251 | 2-Chloro-5-nitro-3-(trifluoromethyl)pyridine >98% | 99368-67-9 | 25g | $160 | 2026-06-04 | Buy |
| Apolloscientific | PC56251 | 2-Chloro-5-nitro-3-(trifluoromethyl)pyridine >98% | 99368-67-9 | 100g | $574 | 2026-06-04 | Buy |
| Apolloscientific | PC56251 | 2-Chloro-5-nitro-3-(trifluoromethyl)pyridine >98% | 99368-67-9 | 500g | $2646 | 2026-06-04 | Buy |
2-Chloro-5-nitro-3-(trifluoromethyl)pyridine Chemical Properties, Uses, Production
Synthesis
99368-66-8
99368-67-9
General procedure for the synthesis of 2-chloro-3-trifluoromethyl-5-nitropyridine from 2-hydroxy-5-nitro-3-trifluoromethylpyridine: Thionyl chloride (SOCl2, 18.45 mL, 253 mmol) was slowly added dropwise to a reaction vial containing 5-nitro-3-(trifluoromethyl)pyridin-2-ol (2.63 g, 12.64 mmol). Subsequently, N,N-dimethylformamide (DMF, 1.957 mL, 25.3 mmol) was added as a catalyst. The reaction mixture was stirred at 100°C for 10 hours. Upon completion of the reaction, the reaction solution was concentrated under reduced pressure to remove excess thionyl chloride. The concentrated residue was extracted by partitioning between ethyl acetate (EA) and saturated sodium bicarbonate (NaHCO3) solution. The organic phases were combined, washed with saturated brine, dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure to afford the crude product 2-chloro-5-nitro-3-(trifluoromethyl)pyridine (2.46 g, 10.86 mmol, 86% yield), which could be used in the next reaction without further purification. Thin layer chromatography (TLC) analysis conditions: petroleum ether/ethyl acetate (PE/EA = 5:1), Rf = 0.6. 1H NMR (400 MHz, CDCl3) δ: 9.23-9.59 (m, 1H), 8.79 (d, J = 2.4 Hz, 1H).
References
[1] Patent: US2014/275111, 2014, A1. Location in patent: Paragraph 0259; 0260
[2] Patent: WO2014/141187, 2014, A1. Location in patent: Page/Page column 49; 59; 63; 87; 88; 124
[3] Patent: US2007/60623, 2007, A1. Location in patent: Page/Page column 39
[4] Patent: WO2016/37578, 2016, A1. Location in patent: Page/Page column 84
[5] Patent: WO2006/42289, 2006, A2. Location in patent: Page/Page column 52
2-Chloro-5-nitro-3-(trifluoromethyl)pyridine Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Sunway Pharmaceutical Technology Co.,Ltd. | 13611835272 13611835272 | mmwang@sunwaypharm.com | China | 44090 | 58 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Shanghai Sphchem Co., Ltd. | 021-56491756 13512199871 | 2819742715@qq.com | China | 3994 | 55 |
| Shanghai yirong biology science and technology co., ltd | 18049974220 | 3060526242@qq.com | China | 999 | 60 |
| Tianjin Jinyuda Chemical Co., Ltd. | 022-58013646 13011382049 | sales@jinyudachem.com | China | 1976 | 55 |
| Nanjing Norris-Pharm Technology Co., Ltd | 13901585132 | sales@norris-pharm.com | China | 8869 | 55 |
| Shanghai Famo Bio-chemical Technology Company Ltd. | 021-36680027 15821745250 | fengqiang@famobiotech.com | China | 494 | 56 |
| SuZhou ShiYa Biopharmaceuticals, Inc. | 86(512)5235 8471 17715136450 | sales@shiyabiopharm.com | China | 4167 | 58 |
View Latest Price from 2-Chloro-5-nitro-3-(trifluoromethyl)pyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-02-02 | 2-Chloro-5-nitro-3-(trifluoroMethyl)pyridine
99368-67-9
|
$1.00 | 1g | 98% | 50tons | Shaanxi Dideu Medichem Co. Ltd | |
 |
2019-07-06 | 2-CHLORO-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE
99368-67-9
|
$1.00 | 1G | 99% | 100KG | Career Henan Chemical Co |
-
- 2-Chloro-5-nitro-3-(trifluoroMethyl)pyridine
99368-67-9
- $1.00
- 98%
- Shaanxi Dideu Medichem Co. Ltd
-
- 2-CHLORO-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE
99368-67-9
- $1.00
- 99%
- Career Henan Chemical Co
