(2,6-DICHLORO-PYRIMIDIN-4-YL)-DIMETHYL-AMINE
- CAS No.
- 117077-93-7
- Chemical Name:
- (2,6-DICHLORO-PYRIMIDIN-4-YL)-DIMETHYL-AMINE
- Synonyms
- 2,6-dichloro-N,N-diMethylpyriMidin-4-aMine;4-dimethylamino-2,6-dichloropyrimidine;2,6-Dichloro-N,N-dimethyl-4-pyrimidinamine;4-Pyrimidinamine, 2,6-dichloro-N,N-dimethyl-;(2,6-DICHLORO-PYRIMIDIN-4-YL)-DIMETHYL-AMINE
- CBNumber:
- CB42449988
- Molecular Formula:
- C6H7Cl2N3
- Molecular Weight:
- 192.05
- MDL Number:
- MFCD09746252
- MOL File:
- 117077-93-7.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
(2,6-DICHLORO-PYRIMIDIN-4-YL)-DIMETHYL-AMINE price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | D436208 | 2,6-Dichloro-N,N-dimethylpyrimidin-4-amine | 117077-93-7 | 500mg | $220 | 2021-12-16 | Buy |
| ChemScene | CS-W000694 | 2,6-Dichloro-N,N-dimethylpyrimidin-4-amine | 117077-93-7 | 100mg | $102 | 2021-12-16 | Buy |
| AK Scientific | 1944AQ | 2,6-dichloro-N,N-dimethylpyrimidin-4-amine | 117077-93-7 | 100mg | $194 | 2021-12-16 | Buy |
| AK Scientific | 1944AQ | 2,6-dichloro-N,N-dimethylpyrimidin-4-amine | 117077-93-7 | 250mg | $323.6 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0356121 | (2,6-DICHLORO-PYRIMIDIN-4-YL)DIMETHYL-AMINE 95.00% | 117077-93-7 | 5MG | $499.52 | 2021-12-16 | Buy |
(2,6-DICHLORO-PYRIMIDIN-4-YL)-DIMETHYL-AMINE Chemical Properties,Uses,Production
Synthesis
3764-01-0
506-59-2
117077-93-7
Under argon protection, 2,4,6-trichloropyrimidine (10 g, 54.64 mmol) was dissolved in dichloromethane (300 mL), cooled to -78 °C and stirred. Subsequently, dimethylamine hydrochloride (4.45 g, 54.64 mmol) was added to this solution. Triethylamine (15.22 mL, 109.29 mmol) was added slowly and the reaction temperature was kept at -78 °C with stirring for 2 hours, followed by a gradual warming to 0 °C over 2 hours. The progress of the reaction was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction mixture was diluted with water (150 mL) and extracted with dichloromethane (2 x 100 mL). The organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography with 20% ethyl acetate/hexane as eluent to afford the target compound 2,6-dichloro-4-N,N-dimethylaminopyrimidine (8.1 g, 77% yield) as a white solid.TLC conditions: 10% ethyl acetate/hexane (Rf 0.4).1H-NMR (500 MHz, DMSO-d6): δ 6.82 (s 1H), 3.09 (s, 6H).
References
[1] Patent: WO2016/168619, 2016, A1. Location in patent: Paragraph 00194
[2] Patent: US2004/82587, 2004, A1. Location in patent: Page/Page column 12
[3] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 13, p. 3408 - 3413
(2,6-DICHLORO-PYRIMIDIN-4-YL)-DIMETHYL-AMINE Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
(2,6-DICHLORO-PYRIMIDIN-4-YL)-DIMETHYL-AMINE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanxi Xuanran Import and Export Trade Co., Ltd. | +8617735180244 | mike_yan@xuanranglobal.com | CHINA | 4017 | 58 |
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| Suzhou ARTK Medchem Co., Ltd. | +86-512-68323658 +86-18168183658 | sales1@artkmedchem.com | China | 39002 | 58 |
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| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42943 | 64 |
| Cantotech Chemicals, Ltd. | 86-0755-86635001 | cantotech@126.com | China | 4566 | 55 |
| Shanghai JONLN Reagent Co., Ltd. | 400-0066400 13621662912 | 422131432@qq.com | China | 9979 | 55 |
