2,4,6-Trichloropyrimidine
- CAS No.
- 3764-01-0
- Chemical Name:
- 2,4,6-Trichloropyrimidine
- Synonyms
- 2,4,6-TRICHLOROPYRIDINE;TCPY;TrichloropyriMidine;2,4,6-trichloro-pyrimidin;NSC 6494;AURORA KA-4834;2,4,6-TrichloropyriM;Xamoterol Impurity 3;6-TrichloropyriMidine;2,4,6-TRICHLOROPYRIMIDINE
- CBNumber:
- CB6466644
- Molecular Formula:
- C4HCl3N2
- Molecular Weight:
- 183.42
- MDL Number:
- MFCD00006063
- MOL File:
- 3764-01-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 23-25 °C (lit.) |
|---|---|
| Boiling point | 210-215 °C (lit.) |
| Density | 1.595 g/mL at 20 °C (lit.) |
| refractive index |
n |
| Flash point | >230 °F |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Chloroform, Ethyl Acetate |
| form | Liquid After Melting |
| pka | -7.14±0.30(Predicted) |
| color | Clear colorless to yellow |
| Water Solubility | Insoluble in water. |
| FreezingPoint | 21.0 to 23.0 ℃ |
| BRN | 118284 |
| InChI | 1S/C4HCl3N2/c5-2-1-3(6)9-4(7)8-2/h1H |
| InChIKey | DPVIABCMTHHTGB-UHFFFAOYSA-N |
| SMILES | Clc1cc(Cl)nc(Cl)n1 |
| CAS DataBase Reference | 3764-01-0(CAS DataBase Reference) |
| FDA UNII | ESA3TV26AP |
| NIST Chemistry Reference | Pyrimidine, 2,4,6-trichloro-(3764-01-0) |
| EPA Substance Registry System | Pyrimidine, 2,4,6-trichloro- (3764-01-0) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | Xn,Xi,T | |||||||||
| Risk Statements | 20/21/22-36/37/38 | |||||||||
| Safety Statements | 26-36-24/25-23 | |||||||||
| RIDADR | UN1759 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29335990 | |||||||||
| Storage Class | 10 - Combustible liquids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
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| Limited Quantities | 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
2,4,6-Trichloropyrimidine price More Price(70)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | T56200 | 2,4,6-Trichloropyrimidine 97% | 3764-01-0 | 25g | $91.5 | 2026-04-30 | Buy |
| TCI Chemical | T0417 | 2,4,6-Trichloropyrimidine >98.0%(GC) | 3764-01-0 | 25g | $107 | 2026-04-30 | Buy |
| TCI Chemical | T0417 | 2,4,6-Trichloropyrimidine >98.0%(GC) | 3764-01-0 | 500g | $1008 | 2026-04-30 | Buy |
| TRC | TRC-T774180-50G | 2,4,6-Trichloropyrimidine | 3764-01-0 | 50g | $139 | 2026-06-03 | Buy |
| TRC | TRC-T774180-25G | 2,4,6-Trichloropyrimidine | 3764-01-0 | 25g | $78 | 2026-06-03 | Buy |
2,4,6-Trichloropyrimidine Chemical Properties,Uses,Production
Chemical Properties
clear colorless to yellowish liquid after melting
Uses
Fungitoxic substance.
Uses
It is applied In selective Suzuki coupling with arylboronic acids has been reported to give 6-arylpyrimidines.
Synthesis Reference(s)
Journal of the American Chemical Society, 80, p. 5481, 1958 DOI: 10.1021/ja01553a042
Synthesis
67-52-7
3764-01-0
Example 2: 128.1 g (1 mol) of barbituric acid and 500 ml (5.5 mol) of phosphorus trichloride were sequentially added to a reaction flask, heated to reflux and maintained for 4 hours. Subsequently, 270 ml (3.1 mol) of phosphorus trichloride and 213 g (3 mol) of chlorine were slowly added dropwise to the reaction system, and the reaction solution was kept as a light yellow suspension during the treatment. The amount of chlorine gas should be strictly controlled during the titration process to avoid overdose, and the specific operation was referred to Example 1. After the titration was completed, the reaction was continued to reflux for 1 hour. After completion of the reaction, phosphorus trichloride is removed by distillation. Finally, 2,4,6-trichloropyrimidine was obtained by distillation under pump vacuum according to the method described in Example 1. The yield of the product was 148 g, the yield was 81% of the theoretical value (in terms of barbituric acid), and the absence of 2,4,5,6-tetrachloropyrimidine in the product was confirmed by GC assay.
Toxics Screening Level
The initial threshold screening level (ITSL) for 2,4,6-trichloropyrimidine is 0.1 μg/m3 based on an annual averaging time.
References
[1] Journal of the American Chemical Society, 1980, vol. 102, # 15, p. 5036 - 5044
[2] Patent: US5898073, 1999, A
[3] Patent: US5712394, 1998, A
[4] Polyhedron, 2014, vol. 81, p. 316 - 322
[5] European Journal of Medicinal Chemistry, 2012, vol. 54, p. 159 - 174
2,4,6-Trichloropyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
1of3
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuhan Xinyangruihe Chemical Technology Co., Ltd. | 13720274133 | 2395204132@qq.com | China | 8000 | 58 |
| shanghai hehua chemical co.,ltd | 15121167815 | bangge121@sina.com | China | 260 | 58 |
| Shanghai Kaisai Chemical Co., Ltd | 021-33516722 13701817765 | kaisaichem@163.com | China | 4604 | 58 |
| Nanbu County Chengxin Technology Co., Ltd. | 0838-5675166 15883665058 | nbcxkj@126.com | China | 956 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TAIYUAN RHF CO.,LTD. | +86 351 7031519 | sales@RHFChem.com | China | 2334 | 56 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
View Lastest Price from 2,4,6-Trichloropyrimidine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 2,4,6-Trichloropyrimidine
3764-01-0
|
$3.00-10.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2025-05-23 | 2,4,6-Trichloropyrimidine
3764-01-0
|
$50.00 | 1kg | 99 | 5000 | Hebei Zhuanglai Chemical Trading Co Ltd | |
 |
2025-04-04 | 2,4,6-Trichloropyrimidine
3764-01-0
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. |
-
- 2,4,6-Trichloropyrimidine
3764-01-0
- $3.00-10.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 2,4,6-Trichloropyrimidine
3764-01-0
- $50.00
- 99
- Hebei Zhuanglai Chemical Trading Co Ltd
-
- 2,4,6-Trichloropyrimidine
3764-01-0
- 98%
- Henan Aochuang Chemical Co.,Ltd.
