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Methyl 5-bromo-1H-pyrrole-3-carboxylate

Methyl 5-bromo-1H-pyrrole-3-carboxylate Structure
Methyl 5-bromo-1H-pyrrole-3-carboxylate structure
CAS No.
16420-39-6
Chemical Name:
Methyl 5-bromo-1H-pyrrole-3-carboxylate
Synonyms
Vonoprazan Impurity 217;Methyl 5-Bromo-3-pyrrolecarboxylate;5-Bromo-3-(methoxycarbonyl)-1H-pyrrole;2-Bromo-4-(methoxycarbonyl)-1H-pyrrole;Methyl 5-bromo-1H-pyrrole-3-carboxylate;Methyl 5-bromo-1H-pyrrole-3-carboxylate 97+%;5-broMo-pyrrole-3-carboxylic acid Methyl ester;1H-Pyrrole-3-carboxylic acid, 5-bromo-, methyl ester
CBNumber:
CB42451637
Molecular Formula:
C6H6BrNO2
Molecular Weight:
204.02
MDL Number:
MFCD09841652
MOL File:
16420-39-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:52:40
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Methyl 5-bromo-1H-pyrrole-3-carboxylate Properties

storage temp. Sealed in dry,Store in freezer, under -20°C
form solid
color Off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
HS Code  2933998090

Methyl 5-bromo-1H-pyrrole-3-carboxylate price More Price(45)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Activate Scientific AS22323 Methyl 5-Bromo-3-pyrrolecarboxylate 97% 16420-39-6 1g $71 2026-06-04 Buy
Activate Scientific AS22323 Methyl 5-Bromo-3-pyrrolecarboxylate 97% 16420-39-6 5g $351 2026-06-04 Buy
Activate Scientific AS22323 Methyl 5-Bromo-3-pyrrolecarboxylate 97% 16420-39-6 25g $1064 2026-06-04 Buy
Apolloscientific OR41103 Methyl 5-bromo-1H-pyrrole-3-carboxylate 95% 16420-39-6 1g $274 2026-06-04 Buy
Matrix Scientific 119492 Methyl 5-bromo-1H-pyrrole-3-carboxylate 16420-39-6 250.00mg $179 2026-05-18 Buy
Product number Packaging Price Buy
AS22323 1g $71 Buy
AS22323 5g $351 Buy
AS22323 25g $1064 Buy
OR41103 1g $274 Buy
119492 250.00mg $179 Buy

Methyl 5-bromo-1H-pyrrole-3-carboxylate Chemical Properties, Uses, Production

Uses

methyl 5-bromo-1H-pyrrole-3-carboxylate is a useful research chemical.

Synthesis

Methyl 1H-pyrrole-3-carboxylate

2703-17-5

METHYL 5-BROMO-1H-PYRROLE-3-CARBOXYLATE

16420-39-6

General procedure for the synthesis of methyl 5-bromo-3-pyrrolecarboxylate from methyl 3-pyrrolecarboxylate: Referring to the literature method (Example 22, Synthesis of methyl 5-bromo-1H-pyrrole-3-carboxylate); dissolve methyl 1H-pyrrole-3-carboxylate (3.06 g) in tetrahydrofuran (30 mL) and cool to -78°C. Under stirring, N-bromosuccinimide (4.38 g) and pyridine (3 drops) were added sequentially. The reaction mixture was kept stirred at -78 °C for 1 hour. After completion of the reaction, water was added to the mixture and extracted with ethyl acetate. The organic layers were combined and washed sequentially with saturated aqueous sodium bicarbonate, water and saturated saline. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: hexane/ethyl acetate=5:1) to afford methyl 5-bromo-3-pyrrolecarboxylate (3.08 g, 62% yield) as a pale yellow solid. The structure of the product was confirmed by 1H-NMR (CDCl3): δ 3.81 (3H, s), 6.58 (1H, m), 7.36 (1H, m), 8.60 (1H, brs).

References

[1] Patent: US2007/60623, 2007, A1. Location in patent: Page/Page column 23
[2] Patent: WO2006/36024, 2006, A1. Location in patent: Page/Page column 116; 286
[3] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 12, p. 3925 - 3938
[4] Patent: EP2336107, 2015, B1. Location in patent: Paragraph 0214
[5] Patent: EP1803709, 2007, A1

Methyl 5-bromo-1H-pyrrole-3-carboxylate Preparation Products And Raw materials

Raw materials

Methyl 1H-pyrrole-3-carboxylate N-Bromosuccinimide Tetrahydrofuran Pyridine

Preparation Products

Methyl 5-bromo-1H-pyrrole-3-carboxylate Suppliers

Global Suppliers ( 71)
Supplier Tel Email Country ProdList Advantage
Shanghai Huasige Pharmaceutical Technology Co., LTD 13611612777 3627377363@qq.com China 4757 58
PharmaBlock Sciences (Nanjing),Inc. 025-86918202 4000255188 sales@pharmablock.com China 5000 55
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd. 21-57721279 18121011378 sales@shydchem.com.cn China 998 56
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 marketing@accelachem.com China 10972 64
Shanghai AmasPharm Co., Ltd. 021-54540637 18621091017 sales@amaspharm.com China 787 62
Shanghai Sunway Pharmaceutical Technology Co., Ltd 13761987713 hxzheng@sunwaypharm.cn China 8663 57
ZhengZhou HuaWen Chemical Co.Ltd 0370-2785118 17550508557 675141927@qq.com China 3201 55
Shanghai Raise Chemical Technology Co.,Ltd +86-021-50935922 China 7854 55
Hebei Summedchem Co.,Ltd 0319-5801333-8008 15630992918 sales@summedchem.com China 1000 58
Supplier Advantage
Shanghai Huasige Pharmaceutical Technology Co., LTD 58
PharmaBlock Sciences (Nanjing),Inc. 55
Energy Chemical 61
Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd. 56
Accela ChemBio Co.,Ltd. 64
Shanghai AmasPharm Co., Ltd. 62
Shanghai Sunway Pharmaceutical Technology Co., Ltd 57
ZhengZhou HuaWen Chemical Co.Ltd 55
Shanghai Raise Chemical Technology Co.,Ltd 55
Hebei Summedchem Co.,Ltd 58

Methyl 5-bromo-1H-pyrrole-3-carboxylate Spectrum

METHYL 5-BROMO-1H-PYRROLE-3-CARBOXYLATE(16420-39-6)1HNMRMETHYL 5-BROMO-1H-PYRROLE-3-CARBOXYLATE(16420-39-6)1HNMR

16420-39-6 (Methyl 5-bromo-1H-pyrrole-3-carboxylate) Related Search:

5-Bromo-6-methoxynicotinic acid methyl ester 5-Bromoindole-3-carboxaldehyde 5-Bromo-1,2,3,4-tetrahydro-[1,7]naphthyridine 1H-Pyrrolo[2,3-b]pyridine-3-carbonitrile, 5-broMo- 5-BroMo-4-azaindole-3-carbaldehyde
5-BroMo-1H-pyrrole-2-carboxylic acid 5-Bromo-1-(2methoxyethyl)-1H-indazole 5-BroMo-[1,2,4]triazolo[4,3-a]pyrazine 5-bromo-1H,2H,3H-pyrrolo[3,2-b]pyridin-2-one 5-BroMo[1,2,4]triazolo[1,5-a]pyrazine
5-Bromoisoquinolin-1(2H)-one Methyl 4,5-dibromo-1H-pyrrole-2-carboxylate 5-Bromopyridine-2-carboxylic acid methyl ester 5-Bromo-1H-indazol-3-amine 5-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid
1,2-Benzisoxazole, 5-bromo- 5-Bromo-1H-indol-3-methylamine 5-Bromo-1H-pyrrolo[3,2-b] pyridine

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Methyl 5-Bromo-3-pyrrolecarboxylate 5-Bromo-3-(methoxycarbonyl)-1H-pyrrole 5-broMo-pyrrole-3-carboxylic acid Methyl ester Methyl 5-bromo-1H-pyrrole-3-carboxylate 97+% 2-Bromo-4-(methoxycarbonyl)-1H-pyrrole 1H-Pyrrole-3-carboxylic acid, 5-bromo-, methyl ester Vonoprazan Impurity 217 Methyl 5-bromo-1H-pyrrole-3-carboxylate 16420-39-6