METHYL 5-BROMO-1H-PYRROLE-3-CARBOXYLATE
- CAS No.
- 16420-39-6
- Chemical Name:
- METHYL 5-BROMO-1H-PYRROLE-3-CARBOXYLATE
- Synonyms
- Vonoprazan Impurity 217;Methyl 5-Bromo-3-pyrrolecarboxylate;5-Bromo-3-(methoxycarbonyl)-1H-pyrrole;2-Bromo-4-(methoxycarbonyl)-1H-pyrrole;METHYL 5-BROMO-1H-PYRROLE-3-CARBOXYLATE;Methyl 5-bromo-1H-pyrrole-3-carboxylate 97+%;5-broMo-pyrrole-3-carboxylic acid Methyl ester;1H-Pyrrole-3-carboxylic acid, 5-bromo-, methyl ester
- CBNumber:
- CB42451637
- Molecular Formula:
- C6H6BrNO2
- Molecular Weight:
- 204.02
- MDL Number:
- MFCD09841652
- MOL File:
- 16420-39-6.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| methyl5-bromo-1H-pyrrole-3-carboxylate | M295343 | 10mg | $45 |
| methyl5-bromo-1H-pyrrole-3-carboxylate | M295343 | 50mg | $110 |
| Methyl 5-bromo-1H-pyrrole-3-carboxylate 95+% | 119492 | 250mg | $179 |
| Methyl 5-bromo-1H-pyrrole-3-carboxylate 95+% | 119492 | 1g | $395 |
| Methyl5-bromo-1H-pyrrole-3-carboxylate | 8344AA | 1g | $262 |
| More product size | |||
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
| HS Code | 2933998090 |
METHYL 5-BROMO-1H-PYRROLE-3-CARBOXYLATE price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | M295343 | methyl5-bromo-1H-pyrrole-3-carboxylate | 16420-39-6 | 10mg | $45 | 2021-12-16 | Buy |
| TRC | M295343 | methyl5-bromo-1H-pyrrole-3-carboxylate | 16420-39-6 | 50mg | $110 | 2021-12-16 | Buy |
| Matrix Scientific | 119492 | Methyl 5-bromo-1H-pyrrole-3-carboxylate 95+% | 16420-39-6 | 250mg | $179 | 2021-12-16 | Buy |
| Matrix Scientific | 119492 | Methyl 5-bromo-1H-pyrrole-3-carboxylate 95+% | 16420-39-6 | 1g | $395 | 2021-12-16 | Buy |
| AK Scientific | 8344AA | Methyl5-bromo-1H-pyrrole-3-carboxylate | 16420-39-6 | 1g | $262 | 2021-12-16 | Buy |
METHYL 5-BROMO-1H-PYRROLE-3-CARBOXYLATE Chemical Properties,Uses,Production
Uses
methyl 5-bromo-1H-pyrrole-3-carboxylate is a useful research chemical.
Synthesis
2703-17-5
16420-39-6
General procedure for the synthesis of methyl 5-bromo-3-pyrrolecarboxylate from methyl 3-pyrrolecarboxylate: Referring to the literature method (Example 22, Synthesis of methyl 5-bromo-1H-pyrrole-3-carboxylate); dissolve methyl 1H-pyrrole-3-carboxylate (3.06 g) in tetrahydrofuran (30 mL) and cool to -78°C. Under stirring, N-bromosuccinimide (4.38 g) and pyridine (3 drops) were added sequentially. The reaction mixture was kept stirred at -78 °C for 1 hour. After completion of the reaction, water was added to the mixture and extracted with ethyl acetate. The organic layers were combined and washed sequentially with saturated aqueous sodium bicarbonate, water and saturated saline. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: hexane/ethyl acetate=5:1) to afford methyl 5-bromo-3-pyrrolecarboxylate (3.08 g, 62% yield) as a pale yellow solid. The structure of the product was confirmed by 1H-NMR (CDCl3): δ 3.81 (3H, s), 6.58 (1H, m), 7.36 (1H, m), 8.60 (1H, brs).
References
[1] Patent: US2007/60623, 2007, A1. Location in patent: Page/Page column 23
[2] Patent: WO2006/36024, 2006, A1. Location in patent: Page/Page column 116; 286
[3] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 12, p. 3925 - 3938
[4] Patent: EP2336107, 2015, B1. Location in patent: Paragraph 0214
[5] Patent: EP1803709, 2007, A1
METHYL 5-BROMO-1H-PYRROLE-3-CARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10035 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30229 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52846 | 58 |
| Nanjing Hengbei Chemicals Co., Ltd. | +86-25-58393656 | sales@hengbeichem.cn | China | 6854 | 58 |
| PT CHEM GROUP LIMITED | +86-85511178; | peter68@ptchemgroup.com | China | 35425 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 49950 | 58 |
| Changzhou AniKare Pharmatech Co., Ltd. | +86-0519-8359-8696 +8618018249389 | sales@anikare.com | China | 9942 | 58 |
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