1-Chloro-6-fluoroisoquinoline
- CAS No.
- 214045-86-0
- Chemical Name:
- 1-Chloro-6-fluoroisoquinoline
- Synonyms
- 1-Chloro-6-fluoroisoquinoline;Isoquinoline, 1-chloro-6-fluoro-
- CBNumber:
- CB42453404
- Molecular Formula:
- C9H5ClFN
- Molecular Weight:
- 181.59
- MDL Number:
- MFCD09959717
- MOL File:
- 214045-86-0.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335-H302 |
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P-P264-P270-P301+P312-P330-P501 |
| HS Code | 2933491090 |
1-Chloro-6-fluoroisoquinoline price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | PC201195 | 1-Chloro-6-fluoroisoquinoline 97% | 214045-86-0 | 100mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC201195 | 1-Chloro-6-fluoroisoquinoline 97% | 214045-86-0 | 250mg | $39 | 2026-06-04 | Buy |
| Apolloscientific | PC201195 | 1-Chloro-6-fluoroisoquinoline 97% | 214045-86-0 | 1g | $124 | 2026-06-04 | Buy |
| Apolloscientific | PC201195 | 1-Chloro-6-fluoroisoquinoline 97% | 214045-86-0 | 5g | $515 | 2026-06-04 | Buy |
| Activate Scientific | AS111250 | 1-Chloro-6-fluoroisoquinoline 97% | 214045-86-0 | 1g | $242 | 2026-06-04 | Buy |
1-Chloro-6-fluoroisoquinoline Chemical Properties, Uses, Production
Synthesis
214045-85-9
214045-86-0
1) Synthesis of 1-chloro-6-fluoroisoquinoline 6-Fluoro-2H-isoquinolin-1-one (1.3 g, 7.97 mmol) (for preparation, see PCT/GB02/00514 and WO 02/062816) was suspended in acetonitrile (20 mL), followed by the addition of phosphorus trichloride (3.7 g, 23.9 mmol). Dioxane solution (2 mL) of 4N hydrochloric acid was added dropwise. The reaction mixture was heated overnight at 50 °C with stirring. Upon completion of the reaction, the mixture was poured into saturated sodium bicarbonate solution and extracted with ethyl acetate. The organic layers were combined and concentrated to give an orange solid product (1.1 g, 78% yield). Mass spectral analysis showed [M+H]+ = 181.8. 1H NMR (300 MHz, CDCl3) δ: 7.42 (m, 2H), 8.26 (m, 3H). 21A) Synthesis of 1-chloro-6-fluoroisoquinoline An acetonitrile (20 mL) solution of 6-fluoro-2H-isoquinolin-1-one (PCT/GB02/00514; WO 02/062816) (1.3 g, 7.97 mmol) and phosphorous triclosan (3.7 g, 23.9 mmol) was heated with a dioxane solution of 4N hydrochloric acid (2 mL) at 50 °C overnight. Upon completion of the reaction, the reaction mixture was diluted with sodium bicarbonate solution and extracted with ethyl acetate. The organic layer was concentrated to give an orange solid product (1.1 g, 78% yield). Mass spectral analysis showed [M+H]+ = 181.8. 1H NMR (400 MHz, CDCl3) δ: 7.42 (m, 2H), 8.26 (m, 3H).
References
[1] Patent: WO2005/28444, 2005, A1. Location in patent: Page/Page column 47-48; 69-70
1-Chloro-6-fluoroisoquinoline Preparation Products And Raw materials
Raw materials
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Preparation Products
1-Chloro-6-fluoroisoquinoline Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ZEROSCHEM.CO.,LTD. | 10-61256048 13810278579; | sales@zeroschem.com | China | 1407 | 59 |
| ShangHai AmK Pharmaceutical Technology Co., Ltd. | 微信 18019252918 18019252918 | sale@amkchem.com | China | 14975 | 55 |
| ShangHai Wisacheam Pharmaceutical Co., Ltd. | 13817485796 | tim@wisacheampharm.com | China | 3711 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 18916372613 | yanzihan@shyuanye.com | China | 87240 | 60 |
| Radiant Pharma & Tech. Co., Ltd | T:15050866711 | wanglin.chen@radiant-pharma.com | China | 466 | 60 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9784 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Shanghai Kaimo Pharmaceutical Co., Ltd. | 021-50521023 18019779209 | sales@kaimopharm.com | China | 227 | 58 |
| Heze Development Zone chuangli Chemical Co., Ltd. | 0530-+86-530-529 6766，+86-15666160102 15666160102 | info@chuangli-chem.com | China | 906 | 55 |
| Sichuan BoYou Biotechnology Co., Ltd. | 028-65791793 18140026355 | 568470422@qq.com | China | 9961 | 58 |
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