5-(CHLOROMETHYL)-2-METHOXYPYRIDINE
- CAS No.
- 101990-70-9
- Chemical Name:
- 5-(CHLOROMETHYL)-2-METHOXYPYRIDINE
- Synonyms
- 2-methoxy-5-chloromethylpyridine;-(CHLOROMETHYL)-2-METHOXYPYRIDINE;5-(CHLOROMETHYL)-2-METHOXYPYRIDINE;5-(ChloroMerthyl)-2-Methoxy pyridine;Pyridine, 5-(chloroMethyl)-2-Methoxy-
- CBNumber:
- CB42454441
- Molecular Formula:
- C7H8ClNO
- Molecular Weight:
- 157.6
- MDL Number:
- MFCD10697570
- MOL File:
- 101990-70-9.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 5-(Chloromethyl)-2-methoxypyridine | B419733 | 50mg | $90 |
| 5-(Chloromethyl)-2-methoxypyridine | B419733 | 250mg | $350 |
| 5-(Chloromethyl)-2-methoxypyridine | FC139378 | 2g | $250 |
| 5-(CHLOROMETHYL)-2-METHOXYPYRIDINE 95.00% | HCH0367311 | 250MG | $283.5 |
| 5-(Chloromethyl)-2-methoxypyridine | FC139378 | 500mg | $90 |
| More product size | |||
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS05 |
|---|---|
| Signal word | Danger |
| Hazard statements | H314-H335-H302 |
| Precautionary statements | P260-P264-P280-P301+P330+P331-P303+P361+P353-P363-P304+P340-P310-P321-P305+P351+P338-P405-P501-P264-P270-P301+P312-P330-P501 |
5-(CHLOROMETHYL)-2-METHOXYPYRIDINE price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | B419733 | 5-(Chloromethyl)-2-methoxypyridine | 101990-70-9 | 50mg | $90 | 2021-12-16 | Buy |
| TRC | B419733 | 5-(Chloromethyl)-2-methoxypyridine | 101990-70-9 | 250mg | $350 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC139378 | 5-(Chloromethyl)-2-methoxypyridine | 101990-70-9 | 2g | $250 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0367311 | 5-(CHLOROMETHYL)-2-METHOXYPYRIDINE 95.00% | 101990-70-9 | 250MG | $283.5 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC139378 | 5-(Chloromethyl)-2-methoxypyridine | 101990-70-9 | 500mg | $90 | 2021-12-16 | Buy |
5-(CHLOROMETHYL)-2-METHOXYPYRIDINE Chemical Properties,Uses,Production
Uses
5-(Chloromethyl)-2-methoxypyridine is used in preparation of pyrazolopyridine compounds as RET kinase inhibitor for treatment of RET-related diseases.
Synthesis
58584-63-7
101990-70-9
(6-Methoxypyridin-3-yl)methanol (2) (537.8 g, 3.86 mol) obtained in Preparation Example 1 was dissolved in dimethylformamide (1.6 L), cooled in an ice bath under nitrogen protection, and thionyl chloride (310 mL, 4.25 mol) was added slowly and dropwise over a period of 1.3 hours. After the dropwise addition, the reaction mixture was continued to be stirred in an ice bath for 1 hour. Subsequently, toluene (5.4 L) and 2N aqueous sodium hydroxide solution (5.4 L) were sequentially added to the reaction mixture at a temperature not exceeding 23 °C. After stirring for about 10 minutes, the aqueous layer was separated and the organic layer was washed with water (2.7 L). The organic layer was concentrated to dryness under reduced pressure, and toluene (1.0 L) was added to the residue for azeotropic distillation, resulting in 618.8 g of the target product, 5-chloromethyl-2-methoxypyridine (3), as a light yellow oil (556.3 g, 91.4% yield). The structure of the product was confirmed by 1H-NMR (CDCl3): δ (ppm) 8.15 (1H, d, J=2.4 Hz), 7.63 (1H, dd, J=2.4 Hz, 8.4 Hz), 6.75 (1H, d, J=8.4 Hz), 4.55 (2H, s), 3.94 (3H, s).
References
[1] Patent: WO2016/33445, 2016, A1. Location in patent: Paragraph 0259
[2] Tetrahedron, 2014, vol. 70, # 40, p. 7207 - 7220
[3] Patent: US2006/235225, 2006, A1. Location in patent: Page/Page column 4
[4] Patent: US2007/49632, 2007, A1. Location in patent: Page/Page column 38
[5] Patent: US2011/224225, 2011, A1. Location in patent: Page/Page column 23
5-(CHLOROMETHYL)-2-METHOXYPYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10405 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
| Alfa Chemistry | +1-5166625404; | Info@alfa-chemistry.com | United States | 20405 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25356 | 58 |
| Aceschem Inc. | +1-817863-6948 +1-（817）863-6948 | sales@aceschem.com | United States | 19632 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| DAYANG CHEM (HANGZHOU) CO.,LTD | +86-88938639 +86-17705817739 | info@dycnchem.com | China | 53899 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Jinan Trio PharmaTech Co., Ltd. | 0531-88811783 | sales@trio-pharmatech.com | China | 1856 | 62 |
