6-Methoxynicotinaldehyde
- CAS No.
- 65873-72-5
- Chemical Name:
- 6-Methoxynicotinaldehyde
- Synonyms
- 6-METHOXY-PYRIDINE-3-CARBALDEHYDE;6-METHOXYNICOTINALDEHYDE;6-Methxoynicotinaldehyde;3-FORMYL-6-METHOXYPYRIDINE;5-FORMYL-2-METHOXYPYRIDINE;6-METHOXY-3-NICOTINALDEHYDE;6-Methoxy-3-pyridinecarbaldehyde;6-METHOXY-3-PYRIDINECARBOXALDEHYDE;2-METHOXYPYRIDINE-5-CARBOXALDEHYDE;6-methoxy-3-pyridinecorbaxaldehyde
- CBNumber:
- CB3390560
- Molecular Formula:
- C7H7NO2
- Molecular Weight:
- 137.14
- MDL Number:
- MFCD02683446
- MOL File:
- 65873-72-5.mol
- MSDS File:
- SDS
| Melting point | 51-54 °C (lit.) |
|---|---|
| Boiling point | 65-70 °C(Press: 12 Torr) |
| Density | 1.159±0.06 g/cm3(Predicted) |
| Flash point | 225 °F |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| pka | 1.60±0.10(Predicted) |
| form | Crystalline Powder |
| color | Off-white to light yellow |
| Water Solubility | insoluble |
| InChI | InChI=1S/C7H7NO2/c1-10-7-3-2-6(5-9)4-8-7/h2-5H,1H3 |
| InChIKey | CTAIEPPAOULMFY-UHFFFAOYSA-N |
| SMILES | C1=NC(OC)=CC=C1C=O |
| CAS DataBase Reference | 65873-72-5(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29339900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
6-Methoxynicotinaldehyde price More Price(92)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 533068 | 6-Methoxy-3-pyridinecarboxaldehyde 98% | 65873-72-5 | 1g | $37.5 | 2026-04-30 | Buy |
| Sigma-Aldrich | 533068 | 6-Methoxy-3-pyridinecarboxaldehyde 98% | 65873-72-5 | 5g | $133 | 2026-04-30 | Buy |
| TCI Chemical | M2347 | 6-Methoxy-3-pyridinecarboxaldehyde >98.0%(GC) | 65873-72-5 | 1g | $53 | 2026-04-30 | Buy |
| TCI Chemical | M2347 | 6-Methoxy-3-pyridinecarboxaldehyde >98.0%(GC) | 65873-72-5 | 5g | $176 | 2026-04-30 | Buy |
| AstaTech | 64881 | 5-FORMYL-2-METHOXY-PYRIDINE 97% | 65873-72-5 | 5G | $28 | 2026-04-30 | Buy |
6-Methoxynicotinaldehyde Chemical Properties, Uses, Production
Chemical Properties
off-white to light yellow crystalline powder
Uses
An intermediate for the synthesis of the somatostatic sst3 receptor.
Uses
Substrate used in a synthesis of flavanones via an L-proline-catalyzed condensation with o-hydroxyarylketones.
General Description
6-Methoxy-3-pyridinecarboxaldehyde, also known as 6-methoxy-3-nicotinaldehyde, can be prepared from 5-bromo-2-methoxypyridine.
Synthesis
13472-85-0
68-12-2
65873-72-5
At -78 °C, N-butyllithium (50 mL, 2.5 M hexane solution) was slowly added dropwise to a solution of 5-bromo-2-methoxypyridine (22.4 g, 119.1 mmol) in anhydrous tetrahydrofuran (240 mL). After the dropwise addition, the reaction mixture was continued to be stirred at -78 °C for 90 min. Subsequently, N,N-dimethylformamide (18.5 mL, 238.3 mmol) was added slowly dropwise and stirring was continued for 90 min at -78 °C. Upon completion of the reaction, the mixture was slowly warmed to room temperature. The reaction mixture was poured into saturated sodium bicarbonate solution (1000 mL) and extracted with ether (3 x 250 mL). The organic phases were combined, dried with magnesium sulfate, filtered and concentrated to dryness to give 15.4 g (94% yield) of 6-methoxy-3-pyridinecarboxaldehyde as a light yellow solid. The product was characterized by 1H NMR (DMSO-d6): δ= 9.97 (s, 1H), 8.77 (m, 1H), 8.12 (dd, 1H, J = 8.6, 2.3 Hz), 6.99 (d, 1H, J = 8.7 Hz), 3.97 (s, 3H).LC/MS analysis (Method A): retention time = 0.25 min, purity = 92.8%, calculated mass = 137, [M + H]+ = 138. HPLC analysis (Method C): retention time = 4.9 min, purity = 95.9% (210-370 nm) and 98.7% (256 nm).
References
[1] Synthesis, 2012, vol. 44, # 5, p. 735 - 746
[2] Journal of medicinal chemistry, 2004, vol. 47, # 20, p. 4829 - 4837
[3] Patent: US2006/19965, 2006, A1. Location in patent: Page/Page column 27
[4] Synthesis, 1994, # 1, p. 87 - 92
[5] Synlett, 2009, # 15, p. 2508 - 2512
6-Methoxynicotinaldehyde Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Habo Medical Technology Co., Ltd. | 13376080562 13376090521 | sales@habotech.com | China | 724 | 60 |
| Hangzhou Mingma Technology Co., LTD | 17621758100 | sales@sunmatech.com | China | 139 | 58 |
| Enki Biopharmaceuticals(Shanghai) Limited | +86-21 5768 0965 +86-13916707528 | yusu@enkibiopharma.com | China | 47 | 55 |
| JINAN RUIFENG PHARMACEUTICAL TECHNOLOGY CO.,LTD | 18668921571 | liujnlz@126.com | China | 22 | 58 |
| Hangzhou Copiore Chemical Co., Ltd. | 17300981287 13757145729 | sales@copiore.com | China | 291 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| New Energy Chemicals | 0515-82159099 13770142076 | info@njuchem.com | China | 251 | 65 |
View Latest Price from 6-Methoxynicotinaldehyde manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 6-Methoxynicotinaldehyde
65873-72-5
|
$1.00-200.00 | 1KG | 99%, 99.5% Sublimated | Henan Fengda Chemical Co., Ltd | ||
 |
2026-08-20 | 6-Methoxynicotinaldehyde
65873-72-5
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2026-07-15 | 6-Methyl-3-pyridinecarboxaldehyde
65873-72-5
|
$29.00 | 99.90% | 10g | TargetMol Chemicals Inc. |
-
- 6-Methoxynicotinaldehyde
65873-72-5
- $1.00-200.00
- 99%, 99.5% Sublimated
- Henan Fengda Chemical Co., Ltd
-
- 6-Methoxynicotinaldehyde
65873-72-5
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 6-Methyl-3-pyridinecarboxaldehyde
65873-72-5
- $29.00
- 99.90%
- TargetMol Chemicals Inc.
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