2-Propanone, 1-(2-fluoro-3-methoxy-6-nitrophenyl)-
- CAS No.
- 288385-99-9
- Chemical Name:
- 2-Propanone, 1-(2-fluoro-3-methoxy-6-nitrophenyl)-
- Synonyms
- FMX15115-A3;1-(2-fluoro-3-methoxy-6-nitrophenyl)-2-propanone;2-Propanone, 1-(2-fluoro-3-methoxy-6-nitrophenyl)-
- CBNumber:
- CB42468558
- Molecular Formula:
- C10H10FNO4
- Molecular Weight:
- 227.19
- MDL Number:
- MFCD11977234
- MOL File:
- 288385-99-9.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
2-Propanone, 1-(2-fluoro-3-methoxy-6-nitrophenyl)- price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 310041 | 1-(2-Fluoro-3-methoxy-6-nitrophenyl)propan-2-one | 288385-99-9 | 250.00mg | $56 | 2026-05-19 | Buy |
| Matrix Scientific | 310041 | 1-(2-Fluoro-3-methoxy-6-nitrophenyl)propan-2-one | 288385-99-9 | 1.00g | $86 | 2026-05-19 | Buy |
| Matrix Scientific | 310041 | 1-(2-Fluoro-3-methoxy-6-nitrophenyl)propan-2-one | 288385-99-9 | 5.00g | $296 | 2026-05-19 | Buy |
| Synthonix | F22849 | 1-(2-Fluoro-3-methoxy-6-nitrophenyl)propan-2-one 97% | 288385-99-9 | 100mg | $90 | 2026-05-06 | Buy |
| Synthonix | F22849 | 1-(2-Fluoro-3-methoxy-6-nitrophenyl)propan-2-one 97% | 288385-99-9 | 250mg | $120 | 2026-05-06 | Buy |
2-Propanone, 1-(2-fluoro-3-methoxy-6-nitrophenyl)- Chemical Properties, Uses, Production
Synthesis
288385-96-6
288385-99-9
1,2-Difluoro-3-(2,2-dimethoxypropyl)-4-nitrobenzene (16.2 g, 62 mmol) was used as a raw material and dissolved in methanol (200 ml) at 5 °C. To this solution was added freshly prepared sodium methanol solution (prepared by the reaction of sodium (1.71 g) and methanol (35 ml)). The reaction mixture was gradually warmed up to room temperature and stirred continuously for 3 days. After completion of the reaction, the volatiles were removed by distillation under reduced pressure. The residue was extracted by partitioning with ethyl acetate and 2N hydrochloric acid (1 ml). After the organic layer was concentrated to about 100 ml, THF (100 ml) and 6N hydrochloric acid (25 ml) were added and stirred at room temperature for 1 hour. The volatiles were again removed by distillation under reduced pressure and the residue was extracted by partition with ethyl acetate and water. The organic layer was separated and washed sequentially with water and brine, then dried with anhydrous magnesium sulfate and finally the solvent was evaporated. The residue was purified by column chromatography (eluent: ethyl acetate/petroleum ether, 3/7) to afford the target product 3-acetylmethyl-2-fluoro-1-methoxy-4-nitrobenzene (12.7 g, 90% yield).MS-ESI: 250 [MNa]+. 1H NMR (CDCl3): δ 2.38 (s, 3H), 4.0 (s, 3H), 4.25 ( s, 2H), 7.0 (dd, 1H), 8.05 (d, 1H).
References
[1] Patent: US2003/199491, 2003, A1
[2] Patent: US2003/212055, 2003, A1
[3] Patent: US2003/207878, 2003, A1
2-Propanone, 1-(2-fluoro-3-methoxy-6-nitrophenyl)- Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
2-Propanone, 1-(2-fluoro-3-methoxy-6-nitrophenyl)- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| Shanghai Paulshine Chemical Co., Ltd. | +86-021-37788663 | China | 186 | 64 | |
| Acesys Pharmatech | 18860950986 | tangmanman@zenjipharma.com | China | 1731 | 55 |
| Quzhou AMK BioTech Co., Ltd | 0570-3081766 18357083060 | sales@qzamkbio.com | China | 1200 | 55 |
| Shanghai CP Pharmaceutical Technology Co., Ltd. | 18221530285 | China | 488 | 55 | |
| ChengDu TongChuangYuan Pharmaceutical Co.Ltd | 028-83379370 13880556291 | tcy@tcypharm.com | China | 8696 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Aikon International Limited | 025-58859352 19370895928 | sales01@aikonchem.com | China | 15078 | 58 |
| Shanghai zhigan biotechnology co., LTD | zhiqianbio@126.com | China | 19765 | 58 | |
| Nanjing Becas pharmatech Ltd. | +86-13912903754 13912903754 | info@becaspharma.com | China | 3963 | 58 |
