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ChemicalBook >> CAS DataBase List >>4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile Structure
4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile structure
CAS No.
24391-41-1
Chemical Name:
4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
Synonyms
4-CHLRO-7H-PYRROLO[2,3-D]PYRIMIDINE-5-CARBON;4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-5-carbonitrile;4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile;7H-Pyrrolo[2,3-d]pyriMidine-5-carbonitrile,4-chloro-
CBNumber:
CB42470126
Molecular Formula:
C7H3ClN4
Molecular Weight:
178.58
MDL Number:
MFCD12406095
MOL File:
24391-41-1.mol
MSDS File:
SDS
Last updated:2026-05-28 01:27:54
Request For Quotation

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile Properties

Boiling point 235.3±50.0 °C(Predicted)
Density 1+-.0.1 g/cm3(Predicted)
storage temp. -20°C, sealed storage, away from moisture
form solid
pka 8.84±0.20(Predicted)
color Light yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P305+P351+P338
HazardClass  IRRITANT
HS Code  2933599590

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific OR317011 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile 95% 24391-41-1 100mg $25 2026-06-04 Buy
Apolloscientific OR317011 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile 95% 24391-41-1 250mg $37 2026-06-04 Buy
Apolloscientific OR317011 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile 95% 24391-41-1 1g $77 2026-06-04 Buy
Apolloscientific OR317011 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile 95% 24391-41-1 5g $345 2026-06-04 Buy
Apolloscientific OR317011 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile 95% 24391-41-1 10g $619 2026-06-04 Buy
Product number Packaging Price Buy
OR317011 100mg $25 Buy
OR317011 250mg $37 Buy
OR317011 1g $77 Buy
OR317011 5g $345 Buy
OR317011 10g $619 Buy

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile Chemical Properties, Uses, Production

Synthesis

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbaldehyde oxime

908287-23-0

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

24391-41-1

To a suspension of 4-chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbaldehyde oxime (865 mg, 4.40 mmol, 1.0 eq.) in dichloromethane (20 mL) was slowly added thionyl chloride (3.1 mL, 43.7 mmol, 10.0 eq.). The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the mixture was concentrated under reduced pressure to remove the solvent. The residue was suspended in water (60 mL) and the pH was adjusted slowly to 4 by addition of saturated aqueous sodium bicarbonate.The precipitated solid was collected by diafiltration and washed sequentially with water and ethyl acetate to give the first products. Subsequently, the filtrate was extracted with ethyl acetate (50 mL x 3). The organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated under reduced pressure and the resulting residue was combined with the aforementioned solid. The crude product was recrystallized in a mixed solvent of ethyl acetate/hexane (1:1, v/v) and dried under reduced pressure to give 4-chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile (763 mg, 97% yield).ESI-MS m/z: 178.8 [M + H]+, 176.8 [M - H]+.

References

[1] Patent: WO2013/12915, 2013, A1. Location in patent: Paragraph 00942
[2] Patent: WO2008/12635, 2008, A2. Location in patent: Page/Page column 83
[3] Patent: US2009/5359, 2009, A1. Location in patent: Page/Page column 25
[4] Patent: WO2011/146882, 2011, A1. Location in patent: Page/Page column 110-111
[5] Patent: US2012/122838, 2012, A1. Location in patent: Page/Page column 81-82

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile synthesis

908287-23-0
24391-41-1
Synthesis of 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile from 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbaldehyde oxime

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile Preparation Products And Raw materials

Raw materials

Thiocyanic acid, 4-methylphenyl ester 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbaldehyde oxime 5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine 4-Chloro-5-iodo-7H-pyrrol[2,3-d]pyrimidine Tri-n-butylcyanotin
Dichloromethane 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine Thionyl chloride Tosyl cyanide

1of2

Preparation Products

Methyl 5-cyano-7H-pyrrolo[2,3-d]pyrimidine-4-carboxylate

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile Suppliers

Global Suppliers ( 91)
Supplier Tel Email Country ProdList Advantage
Changzhou Shili Pharmaceutical Technology Co., Ltd 051988727299; 13961229012 shitech@163.com China 299 58
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Tetranov Biopharm 13526569071 sales@leadmedpharm.com China 7881 64
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13770331960 info@chemlin.com.cn China 16305 64
China Langchem Inc. 0086-21-58956006 China 7798 57
SpringPharma Tech Co.,Ltd +86-25-68710855, +86-25-68710897 sales@springpharma.net China 1260 62
Wuhan ariel chemical Co., LTD. 18986259541 18986259541 sales@3stc.com China 3827 58
Shanghai Topbiochem Technology Co., Ltd +86-21-60341587 sales@topbiochem.com China 6166 58
Shanghai Jian Chao Chemical Technology Co., Ltd. 150-2103-5486 18017383231 983544897@qq.com China 9335 55
Nanjing Baifuli Technology Co., Ltd. 25-25-58740604 15951658055 sales@unisyn.cn China 622 58
Supplier Advantage
Changzhou Shili Pharmaceutical Technology Co., Ltd 58
Pure Chemistry Scientific Inc. 62
Tetranov Biopharm 64
Nanjing Chemlin Chemical Co., Ltd 64
China Langchem Inc. 57
SpringPharma Tech Co.,Ltd 62
Wuhan ariel chemical Co., LTD. 58
Shanghai Topbiochem Technology Co., Ltd 58
Shanghai Jian Chao Chemical Technology Co., Ltd. 55
Nanjing Baifuli Technology Co., Ltd. 58

View Latest Price from 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile pictures 2020-01-09 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
24391-41-1
 $1.00 1KG 95%-99% 1ton Career Henan Chemical Co

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile Spectrum

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile(24391-41-1)1HNMR

24391-41-1 (4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile) Related Search:

2'-Deoxyadenosine
4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile 7H-Pyrrolo[2,3-d]pyriMidine-5-carbonitrile,4-chloro- 4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-5-carbonitrile 4-CHLRO-7H-PYRROLO[2,3-D]PYRIMIDINE-5-CARBON 24391-41-1 intermediates Heterocycle-Pyrimidine series