ChemicalBook >> CAS DataBase List >>5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine

5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine

5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine structure

CAS No.: 22276-95-5

Chemical Name:: 5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine

Synonyms: 7-BroMo-6-chloro-7-deazapurine;5-Bromo-4-chloro-7H-pyrro...;5-broMo-4-chloro-7H-pyrrolo[2;5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine;4-chloro-5-bromo-7H-pyrrolo[2,3-d]pyrimidine;5-bromo-4-chloro-1H-pyrrolo[2,3-d]pyrimidine;7H-Pyrrolo[2,3-d]pyrimidine, 5-bromo-4-chloro-;5-bromo-4-chloro-7h-pyrrole [2,3-d] pyrimidine;5-Bromo-4-chloro-7H-pyrrolo[2,3-D]pyrimidine ,98%;JR-13964, 5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine, 95%

CBNumber:: CB01075223

Molecular Formula:: C6H3BrClN3

Molecular Weight:: 232.47

MDL Number:: MFCD09702029

MOL File:: 22276-95-5.mol

MSDS File:: SDS

Last updated:2026-06-04 16:00:12

Request For Quotation

5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine Properties

Melting point	221-225℃
Boiling point	221.0±50.0 °C(Predicted)
Density	2.15±0.1 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
form	solid
pka	9.43±0.20(Predicted)
color	Yellow
Water Solubility	Slightly soluble in water.
InChI	InChI=1S/C6H3BrClN3/c7-3-1-9-6-4(3)5(8)10-2-11-6/h1-2H,(H,9,10,11)
InChIKey	OXLMTRZWMHIZBY-UHFFFAOYSA-N
SMILES	C1=NC(Cl)=C2C(Br)=CNC2=N1
CAS DataBase Reference	22276-95-5
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06

Signal word

Danger

Hazard statements

H301

Precautionary statements

P301+P310

Hazard Codes

Risk Statements

RIDADR

2811

WGK Germany

HazardClass

IRRITANT

HazardClass

6.1

PackingGroup

Ⅲ

HS Code

2933599590

Storage Class

6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects

Hazard Classifications

Acute Tox. 3 Oral

Limited Quantities

5.0 kg (11 lbs) (solid)

Excepted Quantities

Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)

NFPA 704

	1
3		0

5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine price More Price(69)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	720194	7-Bromo-6-chloro-7-deazapurine 95%	22276-95-5	1g	$34.5	2023-06-20	Buy
Usbiological	295541	7-Bromo-6-chloro-7-deazapurine Asreported	22276-95-5	5g	$761	2026-06-03	Buy
Usbiological	295541	7-Bromo-6-chloro-7-deazapurine Asreported	22276-95-5	10g	$1140	2026-06-03	Buy
Usbiological	295541	7-Bromo-6-chloro-7-deazapurine Asreported	22276-95-5	25g	$1703	2026-06-03	Buy
Usbiological	295541	7-Bromo-6-chloro-7-deazapurine Asreported	22276-95-5	50g	$2561	2026-06-03	Buy

Product number	Packaging	Price	Buy
720194	1g	$34.5	Buy
295541	5g	$761	Buy
295541	10g	$1140	Buy
295541	25g	$1703	Buy
295541	50g	$2561	Buy

5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine Chemical Properties, Uses, Production

Uses

It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.

Synthesis

4-chloro-7H-pyrrolo[2,3-d]pyrimidine (30 g/0.02 mol) was dissolved in 75 mL of chloroform, followed by added 3.5 g (0.02 mol) of N-bromosuccinamide. The resulting mixture was refluxed for 1 h. After cooling to room temperature, the precipitate was removed by filtration and dried under reduced pressure to afford 5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine.

References

[1] Organic Letters, 2003, vol. 5, # 20, p. 3587 - 3590
[2] Synthesis, 2011, # 9, p. 1442 - 1446
[3] Archiv der Pharmazie, 2016, vol. 349, # 5, p. 356 - 362
[4] European Journal of Medicinal Chemistry, 2017, vol. 138, p. 543 - 551
[5] Patent: CN107556318, 2018, A. Location in patent: Paragraph 0101-0103; 0106; 0107

5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine synthesis

Synthesis of 5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine from 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine

5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine Preparation Products And Raw materials

Raw materials

N-Bromosuccinimide Formamidine acetate Phosphorus oxitrichloride Sodium iodide Chloroacetaldehyde diethyl acetal

Hydrochloric acid Ethyl cyanoacetate 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine N,N-Dimethylformamide

1of2

Preparation Products

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile JAK3-IN-6

5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine Suppliers

Global Suppliers ( 206)

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Hansi Chemical Industry Co., Ltd.	17717618050	zllg@gh-reagent.com	China	10418	58
Wuhan Hejingxing Biotechnology Co., Ltd	027-13277920701 13277920701	364510545@qq.com	China	298	58
Nanbu County Chengxin Technology Co., Ltd.	0838-5675166 15883665058	nbcxkj@126.com	China	956	55
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
JinYan Chemicals(ShangHai) Co.,Ltd.	13817811078	sales@jingyan-chemical.com	China	9963	60
Shangchem Co., Ltd.	+86-21-68182121		China	881	52
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10174	62

Supplier	Advantage
Shanghai Hansi Chemical Industry Co., Ltd.	58
Wuhan Hejingxing Biotechnology Co., Ltd	58
Nanbu County Chengxin Technology Co., Ltd.	55
J & K SCIENTIFIC LTD.	76
Alfa Aesar	84
Energy Chemical	61
Capot Chemical Co., Ltd	66
JinYan Chemicals(ShangHai) Co.,Ltd.	60
Shangchem Co., Ltd.	52
Pure Chemistry Scientific Inc.	62

View Latest Price from 5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-20	5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine 22276-95-5	$1.10	1g	99.00%	100 Tons Min	Dideu Industries Group Limited
2025-04-04	5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine 22276-95-5		1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
2020-01-09	5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine 22276-95-5	$9.80	1g	≥99%	100kg	Career Henan Chemical Co

5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine
22276-95-5
$1.10
99.00%
Dideu Industries Group Limited

5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine
22276-95-5
98%
Henan Aochuang Chemical Co.,Ltd.

5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine
22276-95-5
$9.80
≥99%
Career Henan Chemical Co

5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine Spectrum

5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine(22276-95-5)¹HNMR

22276-95-5 (5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine) Related Search:

5-Bromo-7-nitroindoline 4-Amino-7H-pyrrolo[2,3-d]pyrimidine 2-Amino-4-chloropyrrolo[2,3-d]pyrimidine 2-Thiouracil 4-Chloro-5-iodo-7H-pyrrol[2,3-d]pyrimidine

Pyrrolo[2,3-d]pyrimidin-4-ol N4-Benzoylcytosine 4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine 4-Aminopyrazolo[3,4-d]pyrimidine 5-Bromo-1H-pyrrolo[2 , 3-b]pyridin-2(3H)-one

2,4-Dichloro-5H-pyrrolo[3,2-d]pyrimidine Chlorobromoisocyanurate 1-Bromo-3-chloro-5,5-dimethylhydantoin 5-Bromo-7-nitro-1H-indazole Bromochloromethane

Difluorochloromethane 5-bromo-7H-pyrrolo[2,3-d]pyrimidine DEAZAPURINE

1of4

5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine 7-bromo-5-chloro-2,4,9-triazabicyclo[4.3.0]nona-2,4,7,10-tetraene 5-Bromo-4-chloro-7H-pyrrolo[2,3-D]pyrimidine ,98% 5-Bromo-4-chloro-7H-pyrro... 5-broMo-4-chloro-7H-pyrrolo[2 7H-Pyrrolo[2,3-d]pyrimidine, 5-bromo-4-chloro- 7-BroMo-6-chloro-7-deazapurine 5-bromo-4-chloro-1H-pyrrolo[2,3-d]pyrimidine 4-chloro-5-bromo-7H-pyrrolo[2,3-d]pyrimidine JR-13964, 5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine, 95% 5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine ISO 9001：2015 REACH 5-bromo-4-chloro-7h-pyrrole [2,3-d] pyrimidine 22276-95-5 Heterocycle-Pyrimidine series CHIRAL CHEMICALS