DGAT-1 inhibitor
- CAS No.
- 959122-11-3
- Chemical Name:
- DGAT-1 inhibitor
- Synonyms
- A922500;CS-121;DGAT-1 inhibitor;DGAT-1 Inhibitor 4a;A 922500, 10 mM in DMSO;DGAT-1 Inhibitor, A 922500;DGAT-1 inhibitor USP/EP/BP;A922500(DGAT-1 Inhibitor 4a);DGAT-1 Inhibitor A922500 A-922500;DGAT-1 INHIBITOR 4A; A-922500; A922500
- CBNumber:
- CB42470944
- Molecular Formula:
- C26H24N2O4
- Molecular Weight:
- 428.48
- MDL Number:
- MFCD12828780
- MOL File:
- 959122-11-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Density | 1.323 |
|---|---|
| storage temp. | -20°C |
| solubility | ≥21.25 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH |
| form | Light yellow solid |
| color | light yellow |
| biological source | synthetic (organic) |
| InChIKey | BOZRFEQDOFSZBV-DHIUTWEWSA-N |
| SMILES | N(c2ccc(cc2)c3ccc(cc3)C(=O)[C@H]4[C@@H](CCC4)C(=O)O)C(=O)Nc1ccccc1 |
| FDA UNII | 44698M475X |
| UNSPSC Code | 12352204 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06, GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H319-H410 | |||||||||
| Precautionary statements | P273-P301+P310-P305+P351+P338-P501 | |||||||||
| Hazard Codes | T,N | |||||||||
| Risk Statements | 25-36-50 | |||||||||
| Safety Statements | 26-45-61 | |||||||||
| RIDADR | UN 2811 6.1 / PGIII | |||||||||
| WGK Germany | 3 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
DGAT-1 inhibitor price More Price(68)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A1737 | A922500 | 959122-11-3 | 1MG | $67.8 | 2026-04-30 | Buy |
| Sigma-Aldrich | A1737 | A922500 | 959122-11-3 | 5MG | $285 | 2026-04-30 | Buy |
| Sigma-Aldrich | A1737 | A922500 | 959122-11-3 | 10MG | $413 | 2023-06-20 | Buy |
| Sigma-Aldrich | 252801 | DGAT-1 Inhibitor, A 922500 | 959122-11-3 | 5mg | $298 | 2022-05-15 | Buy |
| TCI Chemical | D5994 | A 922500 | 959122-11-3 | 10MG | $169 | 2026-04-30 | Buy |
DGAT-1 inhibitor Chemical Properties, Uses, Production
Uses
A922500 has been used in the inhibition of diacylglycerol acyltransferase (DGAT) in epithelial human breast cancer cell line (MDA-MB-231), digitonin-permeabilized human cancer cells, human myotubes and macrophages.
Definition
ChEBI: A 922500 is an aromatic ketone.
Biological Activity
Diacylglycerol acyltransferase 1 (DGAT-1) inhibitor (IC 50 values are 7 and 24 nM at human and mouse DGAT-1 respectively) that is devoid of activity at DGAT-2, ACAT1 or ACAT2. Induces significant weight loss without altering food intake, and decreases liver and plasma triglyceride levels in vivo . Orally active.
Biochem/physiol Actions
The diacylglycerol acyltransferase (DGAT) 1 inhibitor A922500 was shown to effectively reduce postprandial serum triglyceride levels in rodents at concentrations of 0.03, 0.3 and 3 mg/kg. These results suggest A922500 may have beneficial effects in reducing the risk of cardiovascular disease.
DGAT-1 inhibitor Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuhan TCASChem Technology Co., Ltd. | 027-86697669 13986148687 | sales@tcaschem.com | China | 3997 | 55 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| VDM Biochemicals | 0330-2528181 | sales@vdmbio.com | United States | 510 | 64 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| NCE Biomedical Co.,Ltd. | 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 | China | 1490 | 55 | |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7545 | 61 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29977 | 65 |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2774 | 58 |
View Latest Price from DGAT-1 inhibitor manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-14 | A 922500
959122-11-3
|
$41.00-129.00 | 97.70% | 10g | TargetMol Chemicals Inc. | ||
![(1R,2R)-2-[[4'-[[(Phenylamino)carbonyl]amino][1,1'-biphenyl]-4-yl]carbonyl]cyclopentanecarboxylic acid pictures](https://img.chemicalbook.com/ProductImageEN/2020-1/Small/8bc99468-0952-462c-b2a2-9c76546d4ce8.jpg) |
2020-01-10 | (1R,2R)-2-[[4'-[[(Phenylamino)carbonyl]amino][1,1'-biphenyl]-4-yl]carbonyl]cyclopentanecarboxylic acid
959122-11-3
|
$9.80 | 1KG | ≥98% | 20 tons | Career Henan Chemical Co |
-
- A 922500
959122-11-3
- $41.00-129.00
- 97.70%
- TargetMol Chemicals Inc.
-
- (1R,2R)-2-[[4'-[[(Phenylamino)carbonyl]amino][1,1'-biphenyl]-4-yl]carbonyl]cyclopentanecarboxylic acid
959122-11-3
- $9.80
- ≥98%
- Career Henan Chemical Co
