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Nonapeptide-1

Nonapeptide-1 structure

CAS No.: 158563-45-2

Chemical Name:: Nonapeptide-1

Synonyms: melanostatine;Melanostatine-5;Melitan;HKP-217;Neptide-1;ArkTide N91;Jiupeptide-1;NONAPEPTIDE-1;Metanostatine-5;Melitane / Nonapeptide-1

CBNumber:: CB13052001

Molecular Formula:: C61H87N15O9S

Molecular Weight:: 1206.5

MDL Number:: MFCD00672435

MOL File:: 158563-45-2.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-07-28 17:32:21

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Nonapeptide-1 Properties

Density	1.38±0.1 g/cm3(Predicted)
solubility	soluble in water(≥0.1g/ml)
pka	13.32±0.46(Predicted)
form	Solid
color	white or off-white powder
Sequence	Met-Pro-Phe-Arg-Trp-Phe-Lys-Pro-Val-NH2
Cosmetics Ingredients Functions	SKIN CONDITIONING HAIR CONDITIONING
InChIKey	KNFLNGRLKALWRF-LDXSYGEZSA-N
FDA UNII	64W45420K5

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P280-P305+P351+P338

Nonapeptide-1 price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Biosynth	FM108756	(Met5,Pro6,D-Phe7,D-Trp9,Phe10)-α-MSH (5-13)	158563-45-2	500mg	$900	2026-06-04	Buy
Biosynth	FM108756	(Met5,Pro6,D-Phe7,D-Trp9,Phe10)-α-MSH (5-13)	158563-45-2	250mg	$900	2026-06-04	Buy
Biosynth	FM108756	(Met5,Pro6,D-Phe7,D-Trp9,Phe10)-α-MSH (5-13)	158563-45-2	2000mg	$900	2026-06-04	Buy
Biosynth	FM108756	(Met5,Pro6,D-Phe7,D-Trp9,Phe10)-α-MSH (5-13)	158563-45-2	100mg	$900	2026-06-04	Buy
Biosynth	FM108756	(Met5,Pro6,D-Phe7,D-Trp9,Phe10)-α-MSH (5-13)	158563-45-2	1000mg	$900	2026-06-04	Buy

Product number	Packaging	Price	Buy
FM108756	500mg	$900	Buy
FM108756	250mg	$900	Buy
FM108756	2000mg	$900	Buy
FM108756	100mg	$900	Buy
FM108756	1000mg	$900	Buy

Nonapeptide-1 Chemical Properties, Uses, Production

Description

Nonapeptide-1 is a skin lightening peptide, derived from the melanocyte stimulating hormone (MSH). It prevents the activity of tyrosine in the melanocytes, melanin synthesis inhibition and helps to even out your skin tone by lessening hyper-pigmentation. This process reduces the formation of unwanted pigmentation, allowing for the control over skin tone and brown spots.

Uses

A skin whitening nonapeptide. It can be applied to various kinds of whitening or spot corrective products.

Application

skin radiance, skin Lightening-whitening, anti-dark spot

Definition

Nonapeptide-1 is one skin whitening nonapeptide. It can be applied to various kinds of whitening or spot corrective products.

benefits

Nonapeptide-1inhibits melanin production originally induced bya-MSH.Whitening, spot-removing as well as preventing hyperpigmentation.Its recommended dosage in skin care products is 0.5~3%.

Biological Functions

1. Inhibit melanin synthesis by interfering with the action of tyrosinase in melanocytes. Reduce hyperpigmentation and lighten darker areas that have been damaged by the sun and certain diseases.2. Interfer with melanocyte stimulating hormone (MSH). MSH increases during pregnancy, as a result of certain medical conditions (e.g. diabetes, Addison’s disease), and as a result of excessive sun exposure.3. Nonapeptide-1, at a concentration of 200 ug/mL, is capable of fully inhibiting the synthesis of melanin in fungi.4. At 100 micromolar concentration, nonapeptide-1 can inhibit 25-35% of tyrosinase activity in animal models and can reduce the melanin content of melanocytes by 27-43%

Biotechnological Applications

Nonapeptide-1 acetate salt, a peptide hormone, is a potent α-Melanocyte-stimulating hormone (α-MSH) antagonist, with an IC50 of 11 nM. Reduces synthesis of melanin and helps decrease skin pigmentation to a substantial degree[1].

Side effects

May cause drowsiness, dizziness, hypotension, or a headache as side-effects when using Nonapeptide-1 Topical medicine. Patients not drink alcohol with medicines as alcohol intensifies drowsiness side-effects.

storage

Common storage 2-8℃, long time storage -20℃.

Nonapeptide-1 Preparation Products And Raw materials

Raw materials

Preparation Products

Nonapeptide-1 Suppliers

Global Suppliers ( 356)

Supplier	Tel	Email	Country	ProdList	Advantage
Emeishan Hongsen Biopharmaceutical Co., Ltd.	0833-6186278 19162541913	sales@hongshengpharm.com	China	99	60
Chengdu Maidisen Biotechnology Co., Ltd.	19981944287	info@cdmds.com	China	111	58
Shandong Jitai Biotech Co., Ltd	18366132549	372278065@qq.com	China	29	58
Cellmano Biotech Limited	0551-65326643 18156095617	info@cellmano.com	China	1010	55
Nanjing Leon Biological Technology Co., Ltd.	025-84523390 -127; 17705183659	sales@njleonbiotech.com	China	5501	55
Chengdu Youngshe Chemical Co., Ltd.	+86-17380623303	Caroline@youngshechem.com	China	4724	58
Hangzhou Go Top Peptide Biotech	0571-88211921 17357109671	sales3@gotopbio.com	China	2988	58
BJV(SHENZHEN) BIOTECH LTD	19006605310	3794036058@qq.com	China	96	58
bociny	18939812306	sales@bociny.com	China	207	58
Chengdu Shengnuo Biological Peptide Technology Co.,Ltd	028-028-88368562 13718238400	liweidan@snbiopharm.com	China	27	58

Supplier	Advantage
Emeishan Hongsen Biopharmaceutical Co., Ltd.	60
Chengdu Maidisen Biotechnology Co., Ltd.	58
Shandong Jitai Biotech Co., Ltd	58
Cellmano Biotech Limited	55
Nanjing Leon Biological Technology Co., Ltd.	55
Chengdu Youngshe Chemical Co., Ltd.	58
Hangzhou Go Top Peptide Biotech	58
BJV(SHENZHEN) BIOTECH LTD	58
bociny	58
Chengdu Shengnuo Biological Peptide Technology Co.,Ltd	58

Nonapeptide-1 + EGCG: Reverses skin photoaging
Nonapeptide-1 is a synthetic whitening ingredient with the sequence Arg-Arg-Asp-Ser-Tyr-Pro-Tyr-Arg-Gly.
Feb 27,2025

Nonapeptide-1: Applications in Skin Care and its Preparation Method
Nonapeptide-1, a synthetic peptide that inhibits alpha-melanocyte-stimulating hormone, effectively lightens sunspots and is ef....
Sep 2,2024

View Latest Price from Nonapeptide-1 manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-15	Nonapeptide-1 158563-45-2	$10.00	15mg	0.98	1kg	Shanghai UCHEM Inc.
2026-09-15	Nonapeptide-1 158563-45-2		1g	99%	100G	WUHAN FORTUNA CHEMICAL CO., LTD
2026-09-14	Nonapeptide-1 158563-45-2		2Kg/Bag	99% up by HPLC, Cosmetic Grade	20 tons	Sinoway Industrial co., ltd.

Nonapeptide-1
158563-45-2
$10.00
0.98
Shanghai UCHEM Inc.

Nonapeptide-1
158563-45-2
99%
WUHAN FORTUNA CHEMICAL CO., LTD

Nonapeptide-1
158563-45-2
$0.00
99% up by HPLC, Cosmetic Grade
Sinoway Industrial co., ltd.

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1of4

L-Methionyl-L-prolyl-D-phenylalanyl-L-arginyl-D-tryptophyl-L-phenylalanyl-L-lysyl-L-prolyl-L-valinamide Melanostatine-5(nonpeptide-1) Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH₂ Melitane / Nonapeptide-1 Nonapeptide-1, Melanostatine-5, Melanostatine Melitan Melanostatine-5, Nonapeptide-1 Nonapeptide-1/Melitane/Melanostatine Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val- L-Valinamide, L-methionyl-L-prolyl-D-phenylalanyl-L-arginyl-D-tryptophyl-L-phenylalanyl-L-lysyl-L-prolyl- Cosmetics peptide Nonapeptide-1 powder Nonapeptide-1(Melanostatine-5) Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2 USP/EP/BP hexapeptide-2/Dermostatyl superior quality Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2 CAS 158563-45-2 NONAPEPTIDE-1 CAS 158563-45-2 Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2 Metanostatine-5 (Met?,Pro?,D-Phe?,D-Trp?,Phe1?)-α-MSH (5-13) (Met?,Pro?,D-Phe?,D-Trp?,Phe??)-α-MSH (5-13) Jiupeptide-1 Neptide-1 ArkTide N91 Bright-NP (Nonapeptide-1) HKP-217 Melanostatine-5 melanostatine 158563-45-2 951-78-9 15858-45-2 158563-43-2 C61H87N15O9S 158563-45-2