Z-Vad-fmk, non-methylated
- CAS No.
- 161401-82-7
- Chemical Name:
- Z-Vad-fmk, non-methylated
- Synonyms
- Z-VAD;abs817872;Z-VAD-FMK, Free Acid;Z-VAD-FMK, 10 mM in DMSO;Z-VAD-FMK (Caspase Inhibitor VI);Z-VAD(OH)-FMK (Caspase Inhibitor VI);Z-VAL-ALA-ASP-(OH)-FLUOROMETHYL KETONE;Carbobenzyloxy-Val-Ala-Asp-alpha-fluoromethylketone;Caspase Inhibitor VI - CAS 161401-82-7 - Calbiochem;inhibit,Inhibitor,ZVADFMK,Hela,Z VAD FMK,Caspase,Antiapoptosis,cells,pan-caspase
- CBNumber:
- CB42497499
- Molecular Formula:
- C21H28FN3O7
- Molecular Weight:
- 453.46
- MDL Number:
- MOL File:
- 161401-82-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 758.0±60.0 °C(Predicted) |
|---|---|
| Density | 1.260±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO:5.0(Max Conc. mg/mL);11.0(Max Conc. mM) |
| form | Off-white solid |
| pka | 3.91±0.19(Predicted) |
| color | White to light yellow |
| InChIKey | KCZVXULVWPSIGV-YEWWUXTCSA-N |
| SMILES | C(N)(=O)[C@H](C)N(C(=O)[C@H](C(C)C)NC(OCC1=CC=CC=C1)=O)[C@@H](CC(O)=O)C(=O)CF |
| UNSPSC Code | 12352209 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| PPE | Eyeshields, Gloves, type N95 (US) |
| WGK Germany | WGK 1 |
| Storage Class | 11 - Combustible Solids |
Z-Vad-fmk, non-methylated price More Price(46)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 219007 | Caspase Inhibitor VI - CAS 161401-82-7 - Calbiochem Z-VAD-FMK, CAS 161401-82-7, is an irreversible pan caspase inhibitor. Does not require pretreatment with esterase for in vitro studies. | 161401-82-7 | 250μg | $124 | 2026-04-30 | Buy |
| Sigma-Aldrich | 219007 | Caspase Inhibitor VI - CAS 161401-82-7 - Calbiochem Z-VAD-FMK, CAS 161401-82-7, is an irreversible pan caspase inhibitor. Does not require pretreatment with esterase for in vitro studies. |
161401-82-7 | 1mg | $335 | 2026-04-30 | Buy |
| Cayman Chemical | 14467 | Z-VAD(OH)-FMK ≥95% | 161401-82-7 | 500μg | $81 | 2026-04-30 | Buy |
| Cayman Chemical | 14467 | Z-VAD(OH)-FMK ≥95% | 161401-82-7 | 1mg | $145 | 2026-04-30 | Buy |
| Cayman Chemical | 14467 | Z-VAD(OH)-FMK ≥95% | 161401-82-7 | 5mg | $418 | 2026-04-30 | Buy |
Z-Vad-fmk, non-methylated Chemical Properties, Uses, Production
Description
Z-
Uses
Z-VAD-FMK (Z-VAD(OH)-FMK) is a well-know pan caspase inhibitor, which does not inhibit ubiquitin carboxy-terminal hydrolase L1 (UCHL1) activity even at concentrations as high as 440 μM[1].
General Description
An irreversible general caspase inhibitor. Useful for studies involving recombinant, isolated, and purified caspase enzymes. Unlike Caspase Inhibitor I (Cat. No. 627610), this inhibitor does not require pretreatment with esterase for in vitro studies. A 10 mM (1 mg/221 μl) solution of Caspase Inhibitor VI (Cat. No. 219011) in DMSO is also available.
Biochem/physiol Actions
Product does not compete with ATP.
IC 50
Caspase
References
[1] Davies CW, et al. The co-crystal structure of ubiquitin carboxy-terminal hydrolase L1 (UCHL1) with a tripeptide fluoromethyl ketone (Z-VAE(OMe)-FMK). Bioorg Med Chem Lett. 2012 Jun 15;22(12):3900-4. DOI:10.1016/j.bmcl.2012.04.124
[2] Liu HR, et al. Antiproliferative activity of the total saponin of Solanum lyratum Thunb in Hela cells by inducing apoptosis. Pharmazie. 2008 Nov;63(11):836-42. PMID:19069247
Z-Vad-fmk, non-methylated Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Zhengyi Pharmaceutical Co., Ltd | 17740884366 | derek1229@163.com | China | 61 | 58 |
| Nantong Hi-Future Biotechnology Co., Ltd | +86-0513; 18051384581 | sales@chemhifuture.com | China | 3075 | 58 |
| Shanghai Fine Biotech Co.，Ltd | 18221172427; 18221172427 | sale@fine-biotech.com | China | 227 | 58 |
| Shanghai Zhuyan Biotechnology Co., Ltd. | 17521259211 | 17521259211@163.com | China | 136 | 58 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15350 | 60 |
| Nanjing Dulai Biotechnology Co., Ltd. | 025-84699383-8003;025-846993838003-8003 18013301590 | njduly@126.com | China | 3293 | 55 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185 | sales-cpd@caerulumpharma.com | China | 3493 | 58 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
