- Z-VAD-FMK
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- $121.00
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2026-09-10
- CAS:161401-82-7
- Purity: 98.63%
- Supply Ability: 10g
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| | Z-Vad-fmk, non-methylated Basic information |
| Product Name: | Z-Vad-fmk, non-methylated | | Synonyms: | Z-VAD(OH)-FMK (Caspase Inhibitor VI);Z-VAL-ALA-ASP-(OH)-FLUOROMETHYL KETONE;Z-VAD-FMK (Caspase Inhibitor VI);Carbobenzyloxy-Val-Ala-Asp-alpha-fluoromethylketone;L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-1-(carboxymethyl)-3-fluoro-2-oxopropyl]-;L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-1-(carboxymethyl)-3-fluoro-2-oxopropyl]- (9ci);L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-valyl-N-[1-(carboxymethyl)-3-fluoro-2-oxopropyl]-, (S)-;Z-VAD-FMK, Free Acid | | CAS: | 161401-82-7 | | MF: | C21H28FN3O7 | | MW: | 453.46 | | EINECS: | | | Product Categories: | | | Mol File: | 161401-82-7.mol |  |
| | Z-Vad-fmk, non-methylated Chemical Properties |
| Boiling point | 758.0±60.0 °C(Predicted) | | density | 1.260±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | DMSO:5.0(Max Conc. mg/mL);11.0(Max Conc. mM) | | form | Off-white solid | | pka | 3.91±0.19(Predicted) | | color | White to light yellow | | InChIKey | KCZVXULVWPSIGV-YEWWUXTCSA-N | | SMILES | C(N)(=O)[C@H](C)N(C(=O)[C@H](C(C)C)NC(OCC1=CC=CC=C1)=O)[C@@H](CC(O)=O)C(=O)CF |
| WGK Germany | WGK 1 | | Storage Class | 11 - Combustible Solids |
| | Z-Vad-fmk, non-methylated Usage And Synthesis |
| Description | Z-VAD(OH)-FMK is an irreversible tripeptide inhibitor of all caspases. This non-methylated form is useful in studies involving recombinant, isolated, or purified enzymes. Unlike the methylated form, Z-VAD(OMe)-FMK , this compound does not require pretreatment with esterases prior to in vitro use. | | Uses | Z-VAD-FMK (Z-VAD(OH)-FMK) is a well-know pan caspase inhibitor, which does not inhibit ubiquitin carboxy-terminal hydrolase L1 (UCHL1) activity even at concentrations as high as 440 μM[1]. | | General Description | An irreversible general caspase inhibitor. Useful for studies involving recombinant, isolated, and purified caspase enzymes. Unlike Caspase Inhibitor I (Cat. No. 627610), this inhibitor does not require pretreatment with esterase for in vitro studies. A 10 mM (1 mg/221 μl) solution of Caspase Inhibitor VI (Cat. No. 219011) in DMSO is also available. | | Biochem/physiol Actions | Product does not compete with ATP. | | IC 50 | Caspase | | References | [1] Davies CW, et al. The co-crystal structure of ubiquitin carboxy-terminal hydrolase L1 (UCHL1) with a tripeptide fluoromethyl ketone (Z-VAE(OMe)-FMK). Bioorg Med Chem Lett. 2012 Jun 15;22(12):3900-4. DOI:10.1016/j.bmcl.2012.04.124
[2] Liu HR, et al. Antiproliferative activity of the total saponin of Solanum lyratum Thunb in Hela cells by inducing apoptosis. Pharmazie. 2008 Nov;63(11):836-42. PMID:19069247 |
| | Z-Vad-fmk, non-methylated Preparation Products And Raw materials |
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