Z-FA-FMK
- CAS No.
- 105637-38-5
- Chemical Name:
- Z-FA-FMK
- Synonyms
- Z-PHE-ALA-FLUOROMETHYLKETONE;Z-FA-FMK;Z-PHE-ALA-FMK;Z-PHE-ALA-CH2F;(S,S)-Z-FA-FMK;CATHEPSIN B, INHIBITOR;Z-FA-FLUOROMETHYLKETONE;CATHEPSIN B, INHIBITOR I;CASPASE INHIBITOR, NEGATIVE CONTROL;Z-FA-FMK, Cysteine protease inhibitor
- CBNumber:
- CB9749490
- Molecular Formula:
- C21H23FN2O4
- Molecular Weight:
- 386.42
- MDL Number:
- MFCD00883668
- MOL File:
- 105637-38-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 125 - 127°C |
|---|---|
| Boiling point | 630.5±55.0 °C(Predicted) |
| Density | 1+-.0.06 g/cm3(Predicted) |
| storage temp. | −20°C |
| solubility | DMSO or DMF: 20 mM |
| form | powder |
| pka | 11.07±0.46(Predicted) |
| color | white to off-white |
| InChI | 1S/C21H23FN2O4/c1-15(19(25)13-22)23-20(26)18(12-16-8-4-2-5-9-16)24-21(27)28-14-17-10-6-3-7-11-17/h2-11,15,18H,12-14H2,1H3,(H,23,26)(H,24,27) |
| InChIKey | ASXVEBPEZMSPHB-UHFFFAOYSA-N |
| FDA UNII | 1Q2Z3U96CG |
| UNSPSC Code | 12352209 |
| NACRES | NA.77 |
Z-FA-FMK price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C1480 | Z-Phe-Ala fluoromethyl ketone ≥90% (TLC), powder | 105637-38-5 | 3mg | $318 | 2026-04-30 | Buy |
| ApexBio Technology | A8170 | Z-FA-FMK | 105637-38-5 | EvaluationSample | $30 | 2026-05-06 | Buy |
| ApexBio Technology | A8170 | Z-FA-FMK | 105637-38-5 | 1mg | $66 | 2026-05-06 | Buy |
| ApexBio Technology | A8170 | Z-FA-FMK | 105637-38-5 | 10mM(in1mLDMSO) | $198 | 2026-05-06 | Buy |
| ApexBio Technology | A8170 | Z-FA-FMK | 105637-38-5 | 5mg | $220 | 2026-05-06 | Buy |
Z-FA-FMK Chemical Properties, Uses, Production
Uses
Cell permeable negative control for FMK-labelled caspase inhibitors. Also an irreversible inhibitor of cathepsins B, L, and S
Uses
Z-FA-FMK is an irreversible cysteine protease inhibitor. It also inhibits papain and cruzain.
Biological Activity
Z-Phe-Ala fluoromethyl ketone (Z-FA-FMK) is an inhibitor of cysteine proteases, such as cathepsin B and L. It can also inhibit recombinant effector caspases 2, -3, -6, and -7 and not initiator caspases 8 and -10. Z-FA-FMK plays a role in blocking nuclear factor K-light-chain-enhancer of activated B cells (NF-KB) transactivation. It exhibits therapeutic effects against rheumatoid arthritis.
Z-FA-FMK Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| VDM Biochemicals | 0330-2528181 | sales@vdmbio.com | United States | 510 | 64 |
| Shanghai Harvest Chemical Industrial Co., Ltd. | 15721252604 17321035817 | sales@harvest-chem.com | China | 2829 | 64 |
| Nanjing Dulai Biotechnology Co., Ltd. | 025-84699383-8003;025-846993838003-8003 18013301590 | njduly@126.com | China | 3293 | 55 |
| ApexBio Technology LLC | +1-832-696-8203 | info@apexbt.com | United States | 477 | 60 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9699 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Hangzhou Peptidego Biotech Co.,Ltd. | 0571-87213919 15967184799 | Eric@peptidego.com | China | 7872 | 58 |
| Nanchang Tianzhen Biotechnology Co., Ltd | 13758194781 13173652190 | 522013271@qq.com | China | 2447 | 58 |
| Wuhan Yanzhe Technology Co., Ltd | 15527250409 | wenhaotian12@163.com | China | 4152 | 58 |
