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orvepitant

orvepitant Structure
orvepitant structure
CAS No.
579475-18-6
Chemical Name:
orvepitant
Synonyms
Orvepitat;orvepitan;orvepitant;(2R,4S)-N-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethyl)-2-(4-fluoro-2-methylphenyl)-N-methyl-4;1-Piperidinecarboxamide, N-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-2-(4-fluoro-2-methylphenyl)-4-[(8aS)-hexahydro-6-oxopyrrolo[1,2-a]pyrazin-2(1H)-yl]-N-methyl-, (2R,4S)-
CBNumber:
CB42498830
Molecular Formula:
C31H35F7N4O2
Molecular Weight:
628.62
MDL Number:
MOL File:
579475-18-6.mol
MSDS File:
SDS
Last updated:2025-04-18 09:52:17
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orvepitant Properties

Boiling point 627.5±55.0 °C(Predicted)
Density 1.37±0.1 g/cm3(Predicted)
pka 8.89±0.20(Predicted)
FDA UNII IIU6V0W3JD

orvepitant Chemical Properties, Uses, Production

Uses

Orvepitant (GW823296) is a compound with the ability to inhibit pruritus induced by cancer epidermal growth factor receptor inhibitor (EGFRI) and is a neurokinin-1 receptor antagonist.

References

[1] Neurokinin-1 antagonist orvepitant for EGFRI-induced pruritus in patients with cancer: a randomised, placebo-controlled phase II trial DOI:10.1136/bmjopen-2019-030114

orvepitant Preparation Products And Raw materials

Raw materials

Preparation Products

Orvepitant maleate

orvepitant Suppliers

Global Suppliers ( 6)
Supplier Tel Email Country ProdList Advantage
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 9920 65
ChengDu TongChuangYuan Pharmaceutical Co.Ltd 028-83379370 13880556291 tcy@tcypharm.com China 8696 58
Kaixin Chemical (Hong Kong) Limited 010-88886666-01 13112345678 loyson@qq.com China 589 55
TargetMol Chemicals Inc. 4008200310 15002144251 marketing@tsbiochem.com China 24951 58
Shanghai Billion Chemical Co., Ltd. 18796480002 18796480002 18796480002@163.com China 11994 58
Supplier Advantage
BOC Sciences 65
ChengDu TongChuangYuan Pharmaceutical Co.Ltd 58
Kaixin Chemical (Hong Kong) Limited 55
TargetMol Chemicals Inc. 58
Shanghai Billion Chemical Co., Ltd. 58

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orvepitant orvepitan Orvepitat (2R,4S)-N-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethyl)-2-(4-fluoro-2-methylphenyl)-N-methyl-4 1-Piperidinecarboxamide, N-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-2-(4-fluoro-2-methylphenyl)-4-[(8aS)-hexahydro-6-oxopyrrolo[1,2-a]pyrazin-2(1H)-yl]-N-methyl-, (2R,4S)- 579475-18-6 C31H35F7N4O2