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2-bromo-1-iodo-4-methoxybenzene

2-bromo-1-iodo-4-methoxybenzene Structure
2-bromo-1-iodo-4-methoxybenzene structure
CAS No.
466639-53-2
Chemical Name:
2-bromo-1-iodo-4-methoxybenzene
Synonyms
3-Bromo-4-iodoanisole;3-Bromo-4-iodoanisole97%;3-Bromo-4-iodoanisole 97%;2-bromo-1-iodo-4-methoxybenzene;Benzene, 2-bromo-1-iodo-4-methoxy-;2-Bromo-1-iodo-4-methoxybenzene, 3-Bromo-4-iodophenyl methyl ether
CBNumber:
CB42514923
Molecular Formula:
C7H6BrIO
Molecular Weight:
312.93
MDL Number:
MFCD12547848
MOL File:
466639-53-2.mol
MSDS File:
SDS
Last updated:2026-05-28 02:16:23
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2-bromo-1-iodo-4-methoxybenzene Properties

Boiling point 284.9±25.0 °C(Predicted)
Density 2.062±0.06 g/cm3(Predicted)
refractive index 1.65
storage temp. Keep in dark place,Sealed in dry,Room Temperature
form clear liquid
color Colorless to Red to Green

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P271-P280
HazardClass  IRRITANT
HS Code  2909309090
NFPA 704
1
2 0

2-bromo-1-iodo-4-methoxybenzene price More Price(60)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical B5697 3-Bromo-4-iodoanisole 466639-53-2 1G $38 2026-04-30 Buy
TCI Chemical B5697 3-Bromo-4-iodoanisole 466639-53-2 5G $151 2026-04-30 Buy
Apolloscientific OR61448 3-Bromo-4-iodoanisole 97% 466639-53-2 1g $24 2026-06-04 Buy
Apolloscientific OR61448 3-Bromo-4-iodoanisole 97% 466639-53-2 5g $82 2026-06-04 Buy
Apolloscientific OR61448 3-Bromo-4-iodoanisole 97% 466639-53-2 25g $334 2026-06-04 Buy
Product number Packaging Price Buy
B5697 1G $38 Buy
B5697 5G $151 Buy
OR61448 1g $24 Buy
OR61448 5g $82 Buy
OR61448 25g $334 Buy

2-bromo-1-iodo-4-methoxybenzene Chemical Properties, Uses, Production

Uses

2-bromo-1-iodo-4-methoxybenzene is an ether organic compound used in organic synthesis.

Synthesis

3-Bromoanisole

2398-37-0

2-bromo-1-iodo-4-methoxybenzene

466639-53-2

General procedure for the synthesis of 2-bromo-1-iodo-4-methoxybenzene using 3-bromoanisole as starting material: 3-bromoanisole (10 g, 53.5 mmol), mercuric oxide (HgO, 8.8 g, 40.6 mmol) and acetic anhydride (Ac2O, 1 mL) were dissolved in dichloromethane (CH2Cl2, 100 mL) under stirring conditions, and refluxed for 30 minutes. Subsequently, iodine (I2, 17.6 g, 69.5 mmol) was added in six 12-hour intervals, and refluxing was continued for 12 hours after each addition. Upon completion of the reaction, the reaction mixture was filtered through a diatomaceous earth pad and the filtrate was washed with saturated sodium thiosulfate (Na2S2O3) solution. The aqueous layer was extracted with dichloromethane (3 x 10 mL), the organic layers were combined and dried over anhydrous magnesium sulfate (MgSO4) and subsequently concentrated to dryness under reduced pressure. The crude product was purified by fast column chromatography (with cyclohexane as eluent) to afford the target compound 2-bromo-1-iodo-4-methoxybenzene as a colorless oil (94% yield). The product was characterized by 1H NMR (300 MHz, CDCl3): δ 7.68 (d, J = 8.8 Hz, 1H), 7.19 (d, J = 2.8 Hz, 1H), 6.59 (dd, J = 2.8 Hz, J = 8.8 Hz, 1H), 3.77 (s, 3H).

References

[1] European Journal of Medicinal Chemistry, 2010, vol. 45, # 9, p. 3617 - 3626
[2] Patent: WO2015/121785, 2015, A1. Location in patent: Page/Page column 39; 41
[3] Journal of the American Chemical Society, 2012, vol. 134, # 22, p. 9291 - 9295
[4] Chemical Communications, 2017, vol. 53, # 44, p. 5970 - 5973
[5] Organic and Biomolecular Chemistry, 2018, vol. 16, # 38, p. 7019 - 7028

2-bromo-1-iodo-4-methoxybenzene synthesis

32338-02-6
466639-53-2
Synthesis of 2-bromo-1-iodo-4-methoxybenzene from 2-Bromo-4-methoxy-phenylamine

2-bromo-1-iodo-4-methoxybenzene Preparation Products And Raw materials

Raw materials

Methanesulfonic acid 4-aminophenyl ester Phenol, 4-amino-3-bromo-, 1-methanesulfonate Phenol, 3-bromo-4-iodo-, 1-methanesulfonate 3-Bromo-4-iodophenol 97% p-Nitrophenylmethanesulfonate
4-bromo-1-iodo-2-methoxybenzene 2-Bromo-4-methoxy-phenylamine 4-Nitrophenol Iodomethane p-Anisidine
3-Bromoanisole

1of3

Preparation Products

2-bromo-1-iodo-4-methoxybenzene Suppliers

Global Suppliers ( 107)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
ChemFuture PharmaTech (Jiangsu) Ltd 5108538618 suger.wang@chemfuture.com China 832 65
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Shanghai Harvest Chemical Industrial Co., Ltd. 15721252604 17321035817 sales@harvest-chem.com China 2829 64
Shanghai Sunway Pharmaceutical Technology Co., Ltd 13761987713 hxzheng@sunwaypharm.cn China 8663 57
Shanghai T&W Pharmaceutical Co., Ltd. +86 21 61551611 China 9874 58
Shanghai Jian Chao Chemical Technology Co., Ltd. 150-2103-5486 18017383231 983544897@qq.com China 9335 55
TOKYO CHEMICAL INDUSTRY CO., LTD. 03-36680489 Sales-JP@TCIchemicals.com Japan 28364 80
TCI Europe 320-37350700 sales@tcieurope.eu Europe 23654 75
TCI AMERICA 800-4238616 sales@tciamerica.com Americas 23636 75
Supplier Advantage
J & K SCIENTIFIC LTD. 76
ChemFuture PharmaTech (Jiangsu) Ltd 65
Energy Chemical 61
Shanghai Harvest Chemical Industrial Co., Ltd. 64
Shanghai Sunway Pharmaceutical Technology Co., Ltd 57
Shanghai T&W Pharmaceutical Co., Ltd. 58
Shanghai Jian Chao Chemical Technology Co., Ltd. 55
TOKYO CHEMICAL INDUSTRY CO., LTD. 80
TCI Europe 75
TCI AMERICA 75

View Latest Price from 2-bromo-1-iodo-4-methoxybenzene manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-bromo-1-iodo-4-methoxybenzene pictures 2026-08-07 2-bromo-1-iodo-4-methoxybenzene
466639-53-2
 $1.07-198.65 1Kg 99.0% 60 tons Shaanxi Dideu Medichem Co. Ltd
2-bromo-1-iodo-4-methoxybenzene pictures 2026-06-30 2-bromo-1-iodo-4-methoxybenzene
466639-53-2
 1KG 98.0% 10000KGS Shaanxi Dideu New Materials Co. Ltd
2-bromo-1-iodo-4-methoxybenzene pictures 2019-07-12 2-bromo-1-iodo-4-methoxybenzene
466639-53-2
 $1.00 1KG 99% 100kg Career Henan Chemical Co

2-bromo-1-iodo-4-methoxybenzene Spectrum

2-bromo-1-iodo-4-methoxybenzene(466639-53-2)1HNMR

466639-53-2 (2-bromo-1-iodo-4-methoxybenzene) Related Search:

1-Bromo-2-iodo-3-methoxybenzene 4-Bromo-3-iodoanisole 3-Bromo-4-iodophenol 97% 4-bromo-1-iodo-2-methoxybenzene 2-Bromo-4-iodoanisole
2-Bromo-4-trifluoromethoxy-1-iodobenzene

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2-bromo-1-iodo-4-methoxybenzene 2-Bromo-1-iodo-4-methoxybenzene, 3-Bromo-4-iodophenyl methyl ether 3-Bromo-4-iodoanisole 97% 3-Bromo-4-iodoanisole 3-Bromo-4-iodoanisole97% Benzene, 2-bromo-1-iodo-4-methoxy- 466639-53-2