N-[(1R)-5-(1,1-Dimethylethyl)-2,3-dihydro-1H-inden-1-yl]-N'-1H-indazol-4-ylurea
![N-[(1R)-5-(1,1-Dimethylethyl)-2,3-dihydro-1H-inden-1-yl]-N'-1H-indazol-4-ylurea Structure](CAS2/GIF/808756-71-0.gif)
- CAS No.
- 808756-71-0
- Chemical Name:
- N-[(1R)-5-(1,1-Dimethylethyl)-2,3-dihydro-1H-inden-1-yl]-N'-1H-indazol-4-ylurea
- Synonyms
- ABT-102;CHEMBL398338;ABT-102 (ABT102);ABT 102, 10 mM in DMSO;N-(5-tert-Butylindan-1-yl)-N'-(1H-indazol-4-yl)urea;1-[(1R)-5-tert-butyl-2,3-dihydro-1H-inden-1-yl]-3-(1H-indazol-4-yl)urea;N-[(1R)-5-(1,1-Dimethylethyl)-2,3-dihydro-1H-inden-1-yl]-N'-1H-indazol-4-ylurea;Urea, N-[(1R)-5-(1,1-dimethylethyl)-2,3-dihydro-1H-inden-1-yl]-N'-1H-indazol-4-yl-
- CBNumber:
- CB42516240
- Molecular Formula:
- C21H24N4O
- Molecular Weight:
- 348.44146
- MDL Number:
- MFCD13248650
- MOL File:
- 808756-71-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| ABT 102 | IHB75671 | 50mg | $868 |
| ABT 102 | IHB75671 | 100mg | $1389 |
| ABT-102 98.50% | CS-0002691 | 1mg | $157 |
| ABT-102 98.50% | CS-0002691 | 5mg | $341 |
| ABT-102 98.50% | CS-0002691 | 10mg | $505 |
| Boiling point | 529.5±42.0 °C(Predicted) |
|---|---|
| Density | 1.24 |
| pka | 13.04±0.20(Predicted) |
| FDA UNII | J0YBN3USJN |
N-[(1R)-5-(1,1-Dimethylethyl)-2,3-dihydro-1H-inden-1-yl]-N'-1H-indazol-4-ylurea price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | IHB75671 | ABT 102 | 808756-71-0 | 50mg | $868 | 2026-06-04 | Buy |
| Biosynth | IHB75671 | ABT 102 | 808756-71-0 | 100mg | $1389 | 2026-06-04 | Buy |
| ChemScene | CS-0002691 | ABT-102 98.50% | 808756-71-0 | 1mg | $157 | 2026-06-04 | Buy |
| ChemScene | CS-0002691 | ABT-102 98.50% | 808756-71-0 | 5mg | $341 | 2026-06-04 | Buy |
| ChemScene | CS-0002691 | ABT-102 98.50% | 808756-71-0 | 10mg | $505 | 2026-06-04 | Buy |
N-[(1R)-5-(1,1-Dimethylethyl)-2,3-dihydro-1H-inden-1-yl]-N'-1H-indazol-4-ylurea Chemical Properties,Uses,Production
Uses
ABT-102 is a potent and highly selective Vanilloid Receptor (TRPV1) receptor antagonist. ABT-102 potently and reversibly increases heat pain thresholds and reduced painfulness of suprathreshold oral/cutaneous heat. ABT-102 reduces nociceptive responses of animals in models of inflammatory, bone cancer, postoperative, and osteoarthritic pain[1][2].
IC 50
TRPV1
References
[1] Lukin K, et al. Development of a Large Scale Asymmetric Synthesis of Vanilloid Receptor (TRPV1) Antagonist ABT-102. Organic Process Research & Development, 2007, 11(3):578-584.
[2] Rowbotham MC, et al. Oral and cutaneous thermosensory profile of selective TRPV1 inhibition by ABT-102 in a randomized healthy volunteer trial. Pain. 2011 May;152(5):1192-1200. DOI:10.1016/j.pain.2011.01.051
N-[(1R)-5-(1,1-Dimethylethyl)-2,3-dihydro-1H-inden-1-yl]-N'-1H-indazol-4-ylurea Preparation Products And Raw materials
Raw materials
Preparation Products
N-[(1R)-5-(1,1-Dimethylethyl)-2,3-dihydro-1H-inden-1-yl]-N'-1H-indazol-4-ylurea Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19853 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39039 | 58 |
| Shanghai Synchem Pharma Co., ltd | 21-619849051-1 18521059765 | synchempharma@aliyun.com | China | 4960 | 55 |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9248 | 55 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9804 | 58 |
| Shanghai Biopharmaleader Co., Ltd. | +86 18721201413 | sales@biopharmaleader.com | China | 1720 | 58 |
| Amatek Scientific Co. Ltd. | 0512-56316828 | info@amateksci.com | China | 28769 | 58 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
