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2-Amino-4-Methoxy-5-(3-Morpholinopropoxy)benzonitrile

2-Amino-4-Methoxy-5-(3-Morpholinopropoxy)benzonitrile structure

CAS No.: 675126-27-9

Chemical Name:: 2-Amino-4-Methoxy-5-(3-Morpholinopropoxy)benzonitrile

Synonyms: Gefitinib PI-2;Gefitinib InterMediate;3-Methoxy-4-(3-(piperidin-1-yl)propoxy)benzonitrile;2-Amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile;2-amino-4-methoxy-5-(3-morpholin-4-ylpropoxy)benzonitrile;2-Amino-4-methoxy-5- (3-morpholin-propyloxy) benzonitrile;2-amino-4-methoxy-5-[3-(4-morpholinyl)propoxy]benzonitrile;5-Methoxy-2-nitro-4-(3-(piperidin-1-yl)propoxy)benzonitrile;Benzonitrile,2-aMino-4-Methoxy-5-[3-(4-Morpholinyl)propoxy]-;Benzonitrile, 2-amino-4-methoxy-5-[3-(4-morpholinyl)propoxy]- (9CI, ACI)

CBNumber:: CB42537900

Molecular Formula:: C15H21N3O3

Molecular Weight:: 291.35

MDL Number:: MFCD11110477

MOL File:: 675126-27-9.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:52

Product description	Number	Pack Size	Price
2-Amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile 97%	A58392	250mg	$16
2-Amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile 97%	A58392	1g	$22
2-Amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile 97%	A58392	5g	$110
2-Amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile 97%	A58392	10g	$220
2-Amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile 97%	A58392	25g	$230
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2-Amino-4-Methoxy-5-(3-Morpholinopropoxy)benzonitrile Properties

Melting point	88℃
Boiling point	498.0±45.0 °C(Predicted)
Density	1.21
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
pka	7.08±0.10(Predicted)
Appearance	Off-white to light brown Solid

2-Amino-4-Methoxy-5-(3-Morpholinopropoxy)benzonitrile price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Synthonix	A58392	2-Amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile 97%	675126-27-9	250mg	$16	2026-05-06	Buy
Synthonix	A58392	2-Amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile 97%	675126-27-9	1g	$22	2026-05-06	Buy
Synthonix	A58392	2-Amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile 97%	675126-27-9	5g	$110	2026-05-06	Buy
Synthonix	A58392	2-Amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile 97%	675126-27-9	10g	$220	2026-05-06	Buy
Synthonix	A58392	2-Amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile 97%	675126-27-9	25g	$230	2026-05-06	Buy

Product number	Packaging	Price	Buy
A58392	250mg	$16	Buy
A58392	1g	$22	Buy
A58392	5g	$110	Buy
A58392	10g	$220	Buy
A58392	25g	$230	Buy

2-Amino-4-Methoxy-5-(3-Morpholinopropoxy)benzonitrile Chemical Properties,Uses,Production

Application

2-Amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile can be used as an intermediate for gefitinib in the pharmaceutical research and development process.

Synthesis

675126-26-8

675126-27-9

General procedure for the synthesis of 2-amino-4-methoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile from 4-methoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile: Sodium dithionite (89%, 81.4 kg) was added to a stirred slurry of 4-methoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile (48.8 kg) in water (867 L) , and the resulting mixture was heated to 50 °C. The reaction was completed after about 2 hours. The temperature of the reaction mixture was raised to about 70 °C and a concentrated aqueous hydrochloric acid solution (36%, 270 kg) was slowly added over a period of 3 hours. The resulting mixture was cooled to 20-25 °C while stirring was continued and sodium hydroxide solution (47%, 303.7 kg) was added. The reaction mixture was extracted with dichloromethane (twice, 1082 kg and 541 kg), the organic extracts were combined and washed with deionized water (510 L). Evaporation of the organic phase gave 2-amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile (46.3 kg, 99% yield); melting point 87.5 °C; NMR hydrogen spectrum (DMSO-d6) δ: 1.79 (m, 2H), 2.36 (t, 4H), 2.36 (t, 2H), 3.56 (t, 4H), 3.73 (s, 3H), and 3.86 (t, 2H), 5.66 (br s, 2H), 6.4 (s, 1H), 6.89 (s, 1H); MS: M+H+ 292.

References

[1] Patent: WO2005/23783, 2005, A1. Location in patent: Page/Page column 18
[2] Patent: WO2004/24703, 2004, A1. Location in patent: Page 10
[3] Organic Process Research and Development, 2007, vol. 11, # 5, p. 813 - 816
[4] Patent: CN105503749, 2016, A. Location in patent: Paragraph 0053; 0054; 0055
[5] Patent: CN107586279, 2018, A. Location in patent: Paragraph 0008; 0018

2-Amino-4-Methoxy-5-(3-Morpholinopropoxy)benzonitrile Preparation Products And Raw materials

Raw materials

4-Methoxy-5-[3-(4-morpholinyl)propoxy]-2-nitrobenzonitrile Sodium dithionite

Preparation Products

2-Amino-4-Methoxy-5-(3-Morpholinopropoxy)benzonitrile Suppliers

Global( 109)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29766	58
CONIER CHEM AND PHARMA LIMITED		sales@conier.com	China	49906	58
AFINE CHEMICALS LIMITED	+86-571-85134551 +86-18958018566	info@afinechem.com	China	15030	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 17705817739	info@dycnchem.com	China	52693	58
CD Chemical Group Limited	+86-13651442114	info@codchem.com	China	17253	58
GIHI CHEMICALS CO.,LIMITED	+86-571-86217390; +8618058761490	info@gihichemicals.com	China	49860	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20111	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+86-18621343501	product@acmec-e.com	China	33301	58
ANHUI CHICO CHEMICAL CO., LTD.	13057662806	kirsten@chicopharm.com	China	2620	58
Sinco Pharmachem (ShenZhen) R&D Co., Ltd.	+86-18603013401	jack.lin@sincopharmachem.com	China	9999	58

Supplier	Advantage
career henan chemical co	58
CONIER CHEM AND PHARMA LIMITED	58
AFINE CHEMICALS LIMITED	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
CD Chemical Group Limited	58
GIHI CHEMICALS CO.,LIMITED	58
Henan Fengda Chemical Co., Ltd	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58
ANHUI CHICO CHEMICAL CO., LTD.	58
Sinco Pharmachem (ShenZhen) R&D Co., Ltd.	58

View Lastest Price from 2-Amino-4-Methoxy-5-(3-Morpholinopropoxy)benzonitrile manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2021-03-17	2-amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile 675126-27-9	$50.00	10g	99.8%	10tons	Hebei shuoxi biotechnology co. LTD
	2019-07-06	2-Amino-4-Methoxy-5-(3-Morpholinopropoxy)benzonitrile 675126-27-9	$1.00	1KG	98%	100KG	Career Henan Chemical Co

2-amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile
675126-27-9
$50.00
99.8%
Hebei shuoxi biotechnology co. LTD

2-Amino-4-Methoxy-5-(3-Morpholinopropoxy)benzonitrile
675126-27-9
$1.00
98%
Career Henan Chemical Co

2-Amino-4-Methoxy-5-(3-Morpholinopropoxy)benzonitrile Spectrum

2-Amino-4-Methoxy-5-(3-Morpholinopropoxy)benzonitrile(675126-27-9)¹HNMR

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Gefitinib InterMediate 3-Methoxy-4-(3-(piperidin-1-yl)propoxy)benzonitrile 5-Methoxy-2-nitro-4-(3-(piperidin-1-yl)propoxy)benzonitrile Benzonitrile,2-aMino-4-Methoxy-5-[3-(4-Morpholinyl)propoxy]- Gefitinib PI-2 2-amino-4-methoxy-5-(3-morpholin-4-ylpropoxy)benzonitrile 2-amino-4-methoxy-5-[3-(4-morpholinyl)propoxy]benzonitrile Benzonitrile, 2-amino-4-methoxy-5-[3-(4-morpholinyl)propoxy]- (9CI, ACI) 2-Amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile 2-Amino-4-methoxy-5- (3-morpholin-propyloxy) benzonitrile 675126-27-9