Octanoyl chloride
- CAS No.
- 111-64-8
- Chemical Name:
- Octanoyl chloride
- Synonyms
- OctanoyL;N-OCTANOYL CHLORIDE;CAPRYLYL CHLORIDE;Octanoyl chlorid;OCTANOIC ACID CHLORIDE;OTCL;Xin chloride;Caprylyl chlorid;octanoicchloride;n-Caprylchloride
- CBNumber:
- CB8852845
- Molecular Formula:
- C8H15ClO
- Molecular Weight:
- 162.66
- MDL Number:
- MFCD00000766
- MOL File:
- 111-64-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | -63 °C |
|---|---|
| Boiling point | 195 °C (lit.) |
| Density | 0.953 g/mL at 25 °C (lit.) |
| vapor pressure | 2.5 mm Hg ( 20 °C) |
| refractive index |
n |
| Flash point | 177 °F |
| storage temp. | −20°C |
| solubility | soluble in Chloroform, Methanol |
| form | Liquid |
| color | Clear |
| Odor | pungent odor |
| Water Solubility | REACTS |
| Sensitive | Moisture Sensitive |
| BRN | 635917 |
| Stability | Moisture sensitive |
| InChI | 1S/C8H15ClO/c1-2-3-4-5-6-7-8(9)10/h2-7H2,1H3 |
| InChIKey | REEZZSHJLXOIHL-UHFFFAOYSA-N |
| SMILES | CCCCCCCC(Cl)=O |
| CAS DataBase Reference | 111-64-8(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | BK8FUS6OVT |
| NIST Chemistry Reference | Octanoyl chloride(111-64-8) |
| EPA Substance Registry System | Octanoyl chloride (111-64-8) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS06 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H330-H315-H318-H317-H227-H290 | |||||||||
| Precautionary statements | P501-P272-P260-P210-P234-P271-P264-P280-P284-P302+P352-P370+P378-P390-P362+P364-P333+P313-P304+P340+P310-P305+P351+P338+P310-P403+P233-P403+P235-P406-P405 | |||||||||
| PPE | Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | C,T | |||||||||
| Risk Statements | 34-22-43-41-38-23 | |||||||||
| Safety Statements | 26-36/37/39-45-25-39-37-24 | |||||||||
| RIDADR | UN 3265 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | RH1570000 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29159080 | |||||||||
| Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials |
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| Hazard Classifications | Acute Tox. 2 Inhalation Eye Dam. 1 Met. Corr. 1 Skin Irrit. 2 Skin Sens. 1 |
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| REACH Registrations | Active | |||||||||
| Limited Quantities | 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
Octanoyl chloride price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | O4733 | Octanoyl chloride 99% | 111-64-8 | 5ml | $54.7 | 2026-04-30 | Buy |
| Sigma-Aldrich | O4733 | Octanoyl chloride 99% | 111-64-8 | 100ml | $58.6 | 2026-04-30 | Buy |
| TCI Chemical | O0039 | n-Octanoyl Chloride >99.0%(GC) | 111-64-8 | 25mL | $29 | 2026-04-30 | Buy |
| TCI Chemical | O0039 | n-Octanoyl Chloride >99.0%(GC) | 111-64-8 | 100mL | $47 | 2026-04-30 | Buy |
| Usbiological | 286184 | n-Octanoyl chloride Asreported | 111-64-8 | 50g | $359 | 2026-06-03 | Buy |
Octanoyl chloride Chemical Properties, Uses, Production
Chemical Properties
clear liquid
Uses
Octanoyl chloride is used to produce adhesives. It is used as an acylating agent for a variety of compounds such as sugars (e.g. Sucrose, aromatic compounds (e.g. Anisole and monoglycerides.
Uses
Applications of octanoyl chloride include:
- Synthesis of (R)-2-propyloctanoic acid, a therapeutic agent for Alzheimer′s disease.
- Synthesis of a variety of N-n-octyl-D-gluconamide based organogels.
- Building 2-heptylbenzo[d]thiazole moiety to synthesize conjugated copolymer with fluorine, as cathode interlayer in inverted polymer solar cells (PSCs).
- Octanoyl chloride is one of the essential precursors in the total synthesis of ()-mandelalide L, a marine macrolide that display significant cytotoxicity against human cancer cell lines.
Preparation
Diphosgene (108.8 g) was added to a mixture of octanoic acid (144.2 g) and DMF (1.5 L) at 70 C°. The mixture was left to stand for 1 h, and then nitrogen was bubbled through it for 30 min at 100 C° to give 96.9% of octanoyl chloride (purity 99.99%). Benzoyl chloride and terephthaloyl chloride were similarly prepared.
General Description
Clear colorless to straw-colored liquid with a pungent odor.
Air & Water Reactions
Reacts vigorously with water to form HCl and caprylic acid. Insoluble in water.
Reactivity Profile
Octanoyl chloride is incompatible with bases (including amines), water, alcohols, and with oxidizing agents . May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].
Fire Hazard
Octanoyl chloride is combustible.
Octanoyl chloride Preparation Products And Raw materials
Raw materials
Preparation Products
1of3
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Rolead Chemical Technology Co., Ltd. | 021-69992220 13701886816 | roleadchem@163.com | China | 4602 | 50 |
| CANGZHOU RUNLIQING CHEMICAL CO.,LTD | 199-6973-4477 19933774222 | rlqwyx@163.com | China | 17 | 58 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
View Latest Price from Octanoyl chloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-17 | Octanoyl chloride
111-64-8
|
$1.00 | 25KG | 99% | 2tons | Anhui Royal Chemical Co., Ltd. | |
 |
2026-09-11 | Octanoyl chloride
111-64-8
|
$10.00 | 1Kg | 98% | 1kg;5kg;10kg;100kg;1000kg... | Zjartspharm Co., Ltd | |
 |
2026-05-28 | Octanoyl chloride
111-64-8
|
$15.00 | 1kg | 99% | 10000kg | Hebei Chuanghai Biotechnology Co,.LTD |
-
- Octanoyl chloride
111-64-8
- $1.00
- 99%
- Anhui Royal Chemical Co., Ltd.
-
- Octanoyl chloride
111-64-8
- $10.00
- 98%
- Zjartspharm Co., Ltd
-
- Octanoyl chloride
111-64-8
- $15.00
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
