ethyl 2-(4-broMophenyl)-2-Methylpropanoate
- CAS No.
- 32454-36-7
- Chemical Name:
- ethyl 2-(4-broMophenyl)-2-Methylpropanoate
- Synonyms
- Alectinib Impurity 13;ethyl 2-(4-broMophenyl)-2-Methylpropanoate;2-(4-bromophenyl)-2-methylpropanoic acid ethyl ester;Benzeneacetic acid, 4-bromo-α,α-dimethyl-, ethyl ester
- CBNumber:
- CB42560894
- Molecular Formula:
- C12H15BrO2
- Molecular Weight:
- 271.15
- MDL Number:
- MOL File:
- 32454-36-7.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P280-P305+P351+P338 |
ethyl 2-(4-broMophenyl)-2-Methylpropanoate price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 448760 | Ethyl 2-(4-Bromophenyl)-2-methylpropanoate | 32454-36-7 | 100mg | $382 | 2026-06-03 | Buy |
| Usbiological | 448760 | Ethyl 2-(4-Bromophenyl)-2-methylpropanoate | 32454-36-7 | 250mg | $496 | 2026-06-03 | Buy |
| Activate Scientific | AS45820 | Ethyl 2-(4-bromophenyl)-2-methylpropanoate 95% | 32454-36-7 | 1g | $295 | 2026-06-04 | Buy |
| Activate Scientific | AS45820 | Ethyl 2-(4-bromophenyl)-2-methylpropanoate 95% | 32454-36-7 | 5g | $992 | 2026-06-04 | Buy |
| aablocks | AA00C6SP | Ethyl 2-(4-bromophenyl)-2-methylpropanoate 97% | 32454-36-7 | 1g | $63 | 2026-05-28 | Buy |
ethyl 2-(4-broMophenyl)-2-Methylpropanoate Chemical Properties, Uses, Production
Uses
Ethyl 2-(4-Bromophenyl)-2-methylpropanoate is an intermediate of Alectinib (C183360), a highly selective and potent anaplastic lymphoma kinase (ALK) inhibitor capable of blocking the resistant gatekeeper mutant, which results in reduced cell growth.
Synthesis
14062-25-0
74-88-4
32454-36-7
Example 13A Synthesis of ethyl 2-(4-bromophenyl)-2-methylpropanoate: 2.0 g (8.2 mmol) of ethyl p-bromophenylacetate was dissolved in 50 mL of DMF, and 0.7 g (18 mmol) of a suspension of 60% sodium hydride mineral oil was added slowly at room temperature. The mixture was stirred at room temperature for 30 min before 2.9 g (20.6 mmol) of iodomethane was added. The reaction mixture was continued to stir overnight at room temperature. After completion of the reaction, the reaction mixture was diluted with ethyl acetate and extracted sequentially with water and saturated sodium chloride solution. The organic phase was separated, dried with anhydrous magnesium sulfate, filtered and the filtrate concentrated. The residue was purified by preparative HPLC [Reprosil C18, 10 μm, 250 mm × 40 mm, gradient elution (30% methanol/70% water to 100% methanol), run time 25 min]. After HPLC analysis, the fractions containing the target product were combined and concentrated to give 1.75 g (78% yield) of the product as an oil. The product was characterized by GC-MS [Method 5] and 1H-NMR (400 MHz, DMSO-d6): GC-MS: Rt = 5.10 min; MS (ESIpos): m/z = 270/272 [M+]; 1H-NMR: δ [ppm] = 1.11 (t, 3H), 1.48 (s, 6H), 4.06 (q, 2H ), 7.24-7.29 (m, 2H), 7.50-7.54 (m, 2H).
References
[1] Patent: US2016/318866, 2016, A1. Location in patent: Paragraph 0639; 0640; 0641
[2] Patent: WO2011/44187, 2011, A1. Location in patent: Page/Page column 94
[3] Patent: WO2013/40790, 2013, A1. Location in patent: Page/Page column 60
[4] Patent: WO2013/43624, 2013, A1. Location in patent: Page/Page column 59; 60
[5] Patent: EP3239143, 2017, A2. Location in patent: Paragraph 0339
ethyl 2-(4-broMophenyl)-2-Methylpropanoate Preparation Products And Raw materials
Raw materials
Preparation Products
ethyl 2-(4-broMophenyl)-2-Methylpropanoate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Tetranov Biopharm | 13526569071 | sales@leadmedpharm.com | China | 7881 | 64 |
| Shanghai YuanQi Biotechnology Co., Ltd. | +86-2332782371 +86-18120098618 | sales@adobechem.com | China | 1250 | 50 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9699 | 58 |
| Adobe Chem Co., Ltd. | 2332782371 | adobechem@qq.com | China | 7980 | 58 |
| Aikon International Limited | 025-66061636 19370895928 | qqyang@aikonchem.com | China | 15810 | 58 |
| Shanxi Xuanran Import and Export Trade Co., Ltd. | +8617735180244 | mike_yan@xuanranglobal.com | CHINA | 4011 | 58 |
| Guangzhou Dreampharm Biotechnology Co., Ltd. | 020-36607679; 13502246435 | 3008233746@qq.com | China | 9968 | 12 |
| LEADMEDPHARM CO.,LTD | 13674959855 13674959855 | sales@synthontech.com | China | 3025 | 58 |
| Jinan blalong chemical co. LTD | 2710913286@qq.com | 1513643261@qq.com | China | 14227 | 58 |
| Shanghai Minhan Pharmaceutical Technology Co., Ltd. | 17612188245 | 2816925681@qq.com | China | 8316 | 58 |
