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()-AS 115

()-AS 115 Structure
()-AS 115 structure
CAS No.
926657-43-4
Chemical Name:
()-AS 115
Synonyms
()-AS 115;BTYYXSHZANWPEB-ZWKOTPCHSA-N;(–)-AS 115, CAS 926657-43-4;Carbamic acid, N-[2-[[(1R,2S)-2-(butoxymethyl)cyclohexyl]methoxy]ethyl]-, 2-fluorophenyl ester, rel-
CBNumber:
CB42589767
Molecular Formula:
C21H32FNO4
Molecular Weight:
381.48
MDL Number:
MOL File:
926657-43-4.mol
MSDS File:
SDS
Last updated:2026-07-28 08:09:38
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()-AS 115 Properties

Boiling point 460.272±43.00 °C(Press: 760.00 Torr)(predicted)
Density 1.073±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
solubility DMF: 12 mg/ml; DMSO: 12 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml
pka 10.844±0.46(predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Flame (GHS02)Exclamation Mark (GHS07)
GHS02,GHS07
Signal word  Danger
NFPA 704
3
2 0

()-AS 115 price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 13250 (−)-AS 115 ≥98% 926657-43-4 100μg $66 2026-04-30 Buy
Cayman Chemical 13250 (−)-AS 115 ≥98% 926657-43-4 500μg $285 2026-04-30 Buy
Cayman Chemical 13250 (−)-AS 115 ≥98% 926657-43-4 1mg $503 2026-04-30 Buy
ChemScene CS-0064943 AS115 926657-43-4 1mg $1192 2026-06-04 Buy
aablocks AA00GT7G (-)-AS 115 98%byHPLC 926657-43-4 5mg $306 2026-05-28 Buy
Product number Packaging Price Buy
13250 100μg $66 Buy
13250 500μg $285 Buy
13250 1mg $503 Buy
CS-0064943 1mg $1192 Buy
AA00GT7G 5mg $306 Buy

()-AS 115 Chemical Properties,Uses,Production

Description

KIAA1363 is a 2-acetyl monoacylglyceryl ether (MAGE) hydrolase that is upregulated in aggressive cancers from various tissues.1 The enzyme catalyzes the hydrolysis of the 2-acetyl MAGE to MAGE and serves as a central enzyme in the PAF and LPA signaling network.2 AS 115 is a potent and selective inactivator of KIAA1363, displaying an IC50 value of 150 nM when tested as a racemic mixture in the invasive ovarian cancer cell line SKOV3.2 Treatment of SKOV3 cells with 10 μM AS-115 for 4 hours significantly reduced the formation of MAGE, alkyl-lysophosphatidylcholine, and alkyl-lysophosphatidic acid. The activity of the individual enantiomers of AS 115, i.e. (+)-AS 115 and ()-AS 115, has not been determined.

Uses

AS115 is a potent and selective KIAA1363 inactivator with IC50 value of 150 nM. KIAA1363 is a 2-acetyl monoacylglycerol ether (MAGE) hydrolase that is upregulated in aggressive cancers of various tissues[1][2].

References

1. Jessani, N., Liu, Y., Humphrey, M., et al. Enzyme activity profiles of the secreted and membrane proteome that depict cancer cell invasiveness Proc. Natl. Acad. Sci. USA 99(16),10335-10340(2002).
2. Chiang, K.P., Niessen, S., Saghatelian, A., et al. An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling Chem. Biol. 13(10),1041-1050(2006).

()-AS 115 Preparation Products And Raw materials

Raw materials

Preparation Products

()-AS 115 Suppliers

Global( 20)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9799 58
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 400-920-5774 sales@glpbio.cn China 6705 58
BOC Sciences 16314854226; +8616314854226 inquiry@bocsci.com United States 19852 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11123 58
ShangHai ChuanQian Chemcial Technique Centre 15869524721 3525679403@qq.com China 4565 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912 order@med-bio.cn China 8137 58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd 024-88590548 18698872706 757984502@qq.com China 960 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29874 58
Shaanxi Xihua Chemical Industry Co., Ltd. 18161915376 1096@dideu.com China 485 58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd +86-18341751992 +86-15382112998 757984502@qq.com China 890 58
Supplier Advantage
Shanghai EFE Biological Technology Co., Ltd. 58
Shanghai Hongye Biotechnology Co. Ltd 58
BOC Sciences 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
ShangHai ChuanQian Chemcial Technique Centre 58
MedBioPharmaceutical Technology Inc 58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd 58
TargetMol Chemicals Inc. 58
Shaanxi Xihua Chemical Industry Co., Ltd. 58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd 58

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()-AS 115 BTYYXSHZANWPEB-ZWKOTPCHSA-N Carbamic acid, N-[2-[[(1R,2S)-2-(butoxymethyl)cyclohexyl]methoxy]ethyl]-, 2-fluorophenyl ester, rel- (–)-AS 115, CAS 926657-43-4 926657-43-4 C21H32FNO4