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COX Fluorescent Inhibitor Screening Assay Kit

COX Fluorescent Inhibitor Screening Assay Kit Structure
COX Fluorescent Inhibitor Screening Assay Kit structure
CAS No.
Chemical Name:
COX Fluorescent Inhibitor Screening Assay Kit
Synonyms
COX Fluorescent Inhibitor Screening Assay Kit
CBNumber:
CB42590691
Molecular Formula:
Molecular Weight:
0
MDL Number:
MOL File:
Mol file
Last updated:2025-08-20 16:56:14
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COX Fluorescent Inhibitor Screening Assay Kit price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 700100 COX Fluorescent Inhibitor Screening Assay Kit 192Well $765 2026-04-30 Buy
Product number Packaging Price Buy
700100 192Well $765 Buy

COX Fluorescent Inhibitor Screening Assay Kit Chemical Properties, Uses, Production

Description

Cyclooxygenase (COX, also called Prostaglandin H Synthase or PGHS) is a bifunctional enzyme exhibiting both COX and peroxidase activities. The COX component converts arachidonic acid to a hydroperoxy endoperoxide (PGG2), and the peroxidase component reduces the endoperoxide to the corresponding alcohol (PGH2), the precursor of PGs, thromboxanes, and prostacyclins. It is now well established that there are two distinct isoforms of COX, COX-1 and COX-2. Cayman’s COX Fluorescent Inhibitor Screening Assay provides a convenient fluorescence-based method for screening ovine COX-1 and human recombinant COX-2 for isozyme-specific inhibitors. The assay utilizes the peroxidase component of COXs. In this assay, the reaction between PGG2 and ADHP (10-acetyl-3,7-dihydroxyphenoxazine) produces the highly fluorescent compound resorufin. Resorufin fluorescence can be analyzed with an excitation wavelength of 530-540 nm and an emission wavelength of 585-595 nm.

References

[1] ANTONIO BUZHAREVSKI. Carboranyl Analogues of Ketoprofen with Cytostatic Activity against Human Melanoma and Colon Cancer Cell Lines[J]. ACS Omega, 2019, 4 5: 8824-8833. DOI: 10.1021/acsomega.9b00412
[2] YUE HUANG. Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia.[J]. Journal of Proteome Research, 2019: 677-691.e10. DOI: 10.1016/j.ccell.2019.03.006
[3] ATUL BHARDWAJ. In situ click chemistry generation of cyclooxygenase-2 inhibitors.[J]. Nature Communications, 2017: 1. DOI: 10.1038/s41467-016-0009-6
[4] NIEVES FRESNO. Adamantyl analogues of paracetamol as potent analgesic drugs via inhibition of TRPA1.[J]. PLoS ONE, 2014: e113841. DOI: 10.1371/journal.pone.0113841

COX Fluorescent Inhibitor Screening Assay Kit Preparation Products And Raw materials

Raw materials

Preparation Products

COX Fluorescent Inhibitor Screening Assay Kit Suppliers

Global Suppliers ( 2)
Supplier Tel Email Country ProdList Advantage
Cayman Chemical Company -- sales@caymanchem.com China 6808 58
Cayman Chemical Company -- cayman@caymanchem.com United States 6987 81
Supplier Advantage
Cayman Chemical Company 58
Cayman Chemical Company 81

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COX Fluorescent Inhibitor Screening Assay Kit