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(S)-(-)-1,2,3,4-Tetrahedro-naphthoic acid

(S)-(-)-1,2,3,4-Tetrahedro-naphthoic acid structure

CAS No.: 85977-52-2

Chemical Name:: (S)-(-)-1,2,3,4-Tetrahedro-naphthoic acid

Synonyms: Afobazole Impurity 3;Palonosetron Intermediate 1;Palonosetron interMediater B;(S)-1,2,3,4-TETRAHYDRO-NAPHTHOIC ACID;(S)-1,2,3,4-tetrahydro-1-naphtoic Acid;(S)-1,2,3,4-tetrahydro-1-naphthoic acid;(S)-1,2,3,4-TETRAHUDRO-1-NAPHTHOIC ACID;(S)-(-)-1,2,3,4-TETRAHYDRONAPHTHOIC ACID;D-(-)-1,2,3,4-Tetrahydro-1-naphthoic Acid;(s)-(-)-1,2,3,4-tetrahedro-naphthoic acid

CBNumber:: CB4259099

Molecular Formula:: C11H12O2

Molecular Weight:: 176.21

MDL Number:: MFCD07368365

MOL File:: 85977-52-2.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 03:08:37

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(S)-(-)-1,2,3,4-Tetrahedro-naphthoic acid Properties

Melting point	54-56°C
Boiling point	54-56°C
Density	1.186±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform
form	Solid
pka	4.28±0.20(Predicted)
color	White
InChI	InChI=1S/C11H12O2/c12-11(13)10-7-3-5-8-4-1-2-6-9(8)10/h1-2,4,6,10H,3,5,7H2,(H,12,13)/t10-/m0/s1
InChIKey	VDLWTJCSPSUGOA-JTQLQIEISA-N
SMILES	[C@@H]1(C(O)=O)C2=C(C=CC=C2)CCC1
CAS DataBase Reference	85977-52-2(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Hazard Codes

Xi,Xn

Risk Statements

22-36-51

Safety Statements

26-24/25

HS Code

29163990

NFPA 704

	0
2		0

(S)-(-)-1,2,3,4-Tetrahedro-naphthoic acid price More Price(68)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Usbiological	289866	S-(-)-1,2,3,4-Tetrahedro-naphthoic acid Asreported	85977-52-2	250mg	$372	2026-06-03	Buy
Usbiological	289866	S-(-)-1,2,3,4-Tetrahedro-naphthoic acid Asreported	85977-52-2	500mg	$516	2026-06-03	Buy
Usbiological	289866	S-(-)-1,2,3,4-Tetrahedro-naphthoic acid Asreported	85977-52-2	1g	$711	2026-06-03	Buy
Usbiological	289866	S-(-)-1,2,3,4-Tetrahedro-naphthoic acid Asreported	85977-52-2	2g	$974	2026-06-03	Buy
Usbiological	289866	S-(-)-1,2,3,4-Tetrahedro-naphthoic acid Asreported	85977-52-2	5g	$1351	2026-06-03	Buy

Product number	Packaging	Price	Buy
289866	250mg	$372	Buy
289866	500mg	$516	Buy
289866	1g	$711	Buy
289866	2g	$974	Buy
289866	5g	$1351	Buy

(S)-(-)-1,2,3,4-Tetrahedro-naphthoic acid Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

Intermediate in the preparation of Dipeptidyl Boronate Proteasome Inhibitors.

Synthesis

1914-65-4

(S)-(-)-1,2,3,4-Tetrahedro-naphthoic acid

85977-52-2

General procedure for the synthesis of (S)-tetrahydronaphthalenecarboxylic acid from 1,2,3,4-tetrahydro-1-naphthalenecarboxylic acid: 15.6 g (0.1 mol) of 1,2,3,4-tetrahydronaphthalenecarboxylic acid and 29.8 g (0.1 mol) of quinine were added to 158 mL of a 50% (v/v) aqueous ethanol solution, and stirred for 30 min at 50 °C until complete dissolution. The progress of the reaction was monitored by thin layer chromatography (TLC) with the unfolding agent ratio of petroleum ether (PE):ethyl acetate (EA) = 1:2. Upon completion of the reaction, the reaction solution was cooled to below 0 °C overnight to promote crystallization. Subsequent to filtration, the solid was collected and dried. The dried solid was recrystallized with 90 mL of ethanol, crystallized again at 0 °C, diafiltrated and dried. The resulting product was dissolved in a mixture of 55 mL of 1 mol/L hydrochloric acid and 100 mL of ethyl acetate in a partitioning operation. The organic phase was dried and filtered and concentrated to obtain the crude product. Finally, the crude product was recrystallized from hexane to give 7.21 g of (S)-1,2,3,4-tetrahydronaphthalenecarboxylic acid in the form of white solid in 43.6% yield.

References

[1] Patent: CN108084176, 2018, A. Location in patent: Paragraph 0093; 0102; 0103; 0104
[2] Arkiv foer Kemi, 1958, vol. 12, p. 161,165
[3] Patent: CN107382697, 2017, A

(S)-(-)-1,2,3,4-Tetrahedro-naphthoic acid Preparation Products And Raw materials

Raw materials

Cinchonine 1,2,3,4-Tetrahydro-1-naphthoic acid Acetone Sodium borohydride Carbon dioxide

Tetrahydrofuran Ethyl acetate 1-Tetralone Methanol QUININE SULFATE

Phosphorus tribromide Dimethyl carbonate Petroleum ether Magnesium

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Preparation Products

(S)-(-)-1,2,3,4-Tetrahedro-naphthoic acid Suppliers

Global( 250)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hangzhou Read Chemical Co., Ltd	15306818081	sales@freemindpharm.com	China	50	58
Chengdu Lanqingting Biotech Company Limited	028-87856149; 15208320722	1813129729@qq.com	China	288	58
Jinan Daen Pharmaceutical Technology Co., Ltd	0531-68657833 15905416458	2098511197@qq.com	China	283	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
JinYan Chemicals(ShangHai) Co.,Ltd.	13817811078	sales@jingyan-chemical.com	China	9963	60
Jia Xing Isenchem Co.,Ltd	0573-85285100 18627885956	isenchem@163.com	China	9389	66
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10174	62

Supplier	Advantage
Hangzhou Read Chemical Co., Ltd	58
Chengdu Lanqingting Biotech Company Limited	58
Jinan Daen Pharmaceutical Technology Co., Ltd	58
J & K SCIENTIFIC LTD.	76
Alfa Aesar	84
Energy Chemical	61
Capot Chemical Co., Ltd	66
JinYan Chemicals(ShangHai) Co.,Ltd.	60
Jia Xing Isenchem Co.,Ltd	66
Pure Chemistry Scientific Inc.	62

View Lastest Price from (S)-(-)-1,2,3,4-Tetrahedro-naphthoic acid manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-05-28	(S)-1,2,3,4-tetrahedro-naphthoic acid 85977-52-2	$2.00-5.00	1g	99%	10000kg	Hebei Chuanghai Biotechnology Co,.LTD
2026-03-20	(S)-(-)-1,2,3,4-Tetrahedro-naphthoic acid 85977-52-2	$10.00	1KG	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd
2025-06-27	(S)-(-)-1,2,3,4-Tetrahedro-naphthoic acid 85977-52-2		1KG	99%	500000kg	Hebei Chuanghai Biotechnology Co., Ltd

(S)-1,2,3,4-tetrahedro-naphthoic acid
85977-52-2
$2.00-5.00
99%
Hebei Chuanghai Biotechnology Co,.LTD

(S)-(-)-1,2,3,4-Tetrahedro-naphthoic acid
85977-52-2
$10.00
99%
Hebei Chuanghai Biotechnology Co., Ltd

(S)-(-)-1,2,3,4-Tetrahedro-naphthoic acid
85977-52-2
$0.00
99%
Hebei Chuanghai Biotechnology Co., Ltd

(S)-(-)-1,2,3,4-Tetrahedro-naphthoic acid Spectrum

(S)-(-)-1,2,3,4-Tetrahedro-naphthoic acid(85977-52-2)¹HNMR

85977-52-2((S)-(-)-1,2,3,4-Tetrahedro-naphthoic acid)Related Search:

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(S)-(-)-1,2,3,4-Tetrahedro-naphthoic acid AKOS AUF0789 AKOS AUF0790

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(1S)-1,2,3,4-Tetrahydro-1-naphthalenecarboxylic Acid D-(-)-1,2,3,4-Tetrahydro-1-naphthoic Acid (S)-(-)-1,2,3,4-Tetrahydro-1-naphthoic acid(W.S) (1S)-1-Carboxy-1,2,3,4-tetrahydronaphthalene, (1S)-1,2,3,4-Tetrahydro-1-naphthoic acid Palonosetron interMediater B 1-Naphthalenecarboxylic acid, 1,2,3,4-tetrahydro-,(1S)- (S)-1, 2, 3, 4-Tetrahydronaphthoic acidCAS (S)-1,2,3,4-Tetrahydro-1-naphthoic Acid,99%e.e. (S)-1,2,3,4-TETRAHYDRO-NAPHTHALENE-1-CARBOXYLIC ACID (S)-(-)-1,2,3,4-TETRAHYDRONAPHTHOIC ACID (S)-1,2,3,4-TETRAHYDRO-NAPHTHOIC ACID (s)-(-)-1,2,3,4-tetrahedro-naphthoic acid (S)-1,2,3,4-tetrahydro-1-naphthoic acid (S)-(-)-1,2,3,4-Tetrahedro-1-NaphthoicAcid (S)-1,2,3,4-TETRAHUDRO-1-NAPHTHOIC ACID (S)-1,2,3,4-tetrahydro-1-naphtoic Acid (1S)-1-Carboxy-1,2,3,4-tetrahydronaphthalene (1S)-1,2,3,4-Tetrahydronaphthalene-1-carboxylic acid Palonosetron Intermediate 1 (S)-1,2,3,4-Tetrahydro-1-naphthoic acid, 98%, (SH-(-)-1,2,3,4-Tetrahedro-naphthoic acid (S)-1,2,3,4-Tetrahydro-1-naphthalenecarboxylic acid Afobazole Impurity 3 85977-52-2 Carboxylic Acids & Deriv. CHIRAL CHEMICALS INTERMEDIATESOFPALONOSETRONHYDROCHLORIDE Aromatics Chiral Reagents Intermediates