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ChemicalBook >> CAS DataBase List >>2,4-Morpholinedicarboxylic acid, 4-(1,1-diMethylethyl) 2-Methyl ester

2,4-Morpholinedicarboxylic acid, 4-(1,1-diMethylethyl) 2-Methyl ester

2,4-Morpholinedicarboxylic acid, 4-(1,1-diMethylethyl) 2-Methyl ester Structure
2,4-Morpholinedicarboxylic acid, 4-(1,1-diMethylethyl) 2-Methyl ester structure
CAS No.
500789-41-3
Chemical Name:
2,4-Morpholinedicarboxylic acid, 4-(1,1-diMethylethyl) 2-Methyl ester
Synonyms
4-(tert-butoxycarbonyl)-2-MethylMorpholine-2-carboxylic acid;Methyl N-Boc-2-morpholinecarboxylate;methyl 4-Boc-morpholine-2-carboxylate;tert-butyl methyl morpholine-2,4-dicarboxylate;4-Boc-Morpholine-2-carboxylic acid Methyl ester;4-O-tert-butyl 2-O-methyl morpholine-2,4-dicarboxylate;4-(t-butyloxycarbonyl)morpholine-2-carboxylic acid methyl ester;2,4-Morpholinedicarboxylic acid, 4-(1,1-dimethylethyl) 2-met...;4-(tert-Butyloxycarbonyl)morpholine-2-carboxylic acid methyl ester;2,4-Morpholinedicarboxylic acid, 4-(1,1-diMethylethyl) 2-Methyl ester
CBNumber:
CB42609595
Molecular Formula:
C11H19NO5
Molecular Weight:
245.27
MDL Number:
MFCD14582561
MOL File:
500789-41-3.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 03:25:50
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2,4-Morpholinedicarboxylic acid, 4-(1,1-diMethylethyl) 2-Methyl ester Properties

Boiling point 313.2±42.0 °C(Predicted)
Density 1.149±0.06 g/cm3(Predicted)
storage temp. 2-8°C
pka -2.79±0.40(Predicted)
Appearance White to off-white Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P264-P280-P302+P352-P321-P332+P313-P362-P305+P351+P338-P337+P313-P261-P271-P304+P340-P312-P403+P233-P405-P501
HS Code  2934999090

2,4-Morpholinedicarboxylic acid, 4-(1,1-diMethylethyl) 2-Methyl ester price More Price(38)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific OR955607 Methyl 4-Boc-morpholine-2-carboxylate 99% 500789-41-3 100mg $21 2026-06-04 Buy
Apolloscientific OR955607 Methyl 4-Boc-morpholine-2-carboxylate 99% 500789-41-3 250mg $24 2026-06-04 Buy
Apolloscientific OR955607 Methyl 4-Boc-morpholine-2-carboxylate 99% 500789-41-3 1g $29 2026-06-04 Buy
Apolloscientific OR955607 Methyl 4-Boc-morpholine-2-carboxylate 99% 500789-41-3 5g $102 2026-06-04 Buy
Apolloscientific OR955607 Methyl 4-Boc-morpholine-2-carboxylate 99% 500789-41-3 25g $489 2026-06-04 Buy
Product number Packaging Price Buy
OR955607 100mg $21 Buy
OR955607 250mg $24 Buy
OR955607 1g $29 Buy
OR955607 5g $102 Buy
OR955607 25g $489 Buy

2,4-Morpholinedicarboxylic acid, 4-(1,1-diMethylethyl) 2-Methyl ester Chemical Properties, Uses, Production

Synthesis

4-BOC-2-MORPHOLINECARBOXYLIC ACID

189321-66-2

Iodomethane

74-88-4

2,4-Morpholinedicarboxylic acid, 4-(1,1-diMethylethyl) 2-Methyl ester

500789-41-3

General procedure: Potassium carbonate (K2CO3, 1.190 g, 8.66 mmol) was added to a solution of 4-(tert-butoxycarbonyl)morpholine-2-carboxylic acid (CAS No. 189321-66-2; 0.500 g, 2.164 mmol) in anhydrous N,N-dimethylformamide (DMF, 3 mL), followed by iodomethane (CH3I, 0.922 g, 6.49 mmol) at room temperature. 0.922 g, 6.49 mmol) at room temperature. The reaction mixture was stirred at room temperature for 36 hours. Upon completion of the reaction, the mixture was poured into 1 M hydrochloric acid (HCl, 20 mL) and extracted with ethyl acetate (EtOAc, 3 × 50 mL). The organic phases were combined, washed with water (50 mL), dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure to afford methyl 4-(tert-butoxycarbonyl)-2-morpholinecarboxylate (0.624 g, quantitative yield). The product could be used in the next reaction without further purification. Liquid chromatography-mass spectrometry (LCMS) analysis: method C, retention time 1.756 min; mass spectrometry (MS): electrospray positive ionization mode (ES+) m/z 246.48. The product was analyzed by liquid chromatography-mass spectrometry (LC-MS).

References

[1] Patent: WO2018/60691, 2018, A1. Location in patent: Page/Page column 47
[2] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 9, p. 3072 - 3093
[3] Patent: WO2014/9295, 2014, A1. Location in patent: Page/Page column 175
[4] Patent: WO2004/5295, 2004, A1. Location in patent: Page 155

2,4-Morpholinedicarboxylic acid, 4-(1,1-diMethylethyl) 2-Methyl ester Preparation Products And Raw materials

Raw materials

4-(Phenylmethyl)-2-morpholinecarboxylic acid methyl ester 4-Boc-2-morpholinecarboxylic acid Iodomethane Di-tert-butyl dicarbonate Diiodomethane
N,N-Dimethylformamide Potassium carbonate

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Preparation Products

2-Hydroxymethyl-4-Boc-morpholine 4-tert-butyl 2-ethyl 2-methylmorpholine-2,4-dicarboxylate

2,4-Morpholinedicarboxylic acid, 4-(1,1-diMethylethyl) 2-Methyl ester Suppliers

Global Suppliers ( 51)
Supplier Tel Email Country ProdList Advantage
ForeChem (Nantong) Technology Co.,Ltd. 513-85982855 18921614129 sales@xianxingpharm.com China 2712 61
Amatek Scientific Co. Ltd. 0512-56316828 4008675858 sales@amateksci.com China 9848 55
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Chengdu Firster Pharmaceutical Co., Ltd. 028-87078428 028-87074958 chengzhenyong@cdfirster.com China 2580 60
Shanghai Balmxy Pharmaceutical Co., Ltd 021-24206007 13764915196 sales@balmxy.com China 6959 55
ShangHai AmK Pharmaceutical Technology Co., Ltd. 微信 18019252918 18019252918 sale@amkchem.com China 14982 55
Shanghai Mayzem Pharmtech Co., Ltd. 18501708306; 18501708306 sales@mayzem.com China 518 56
ShangHai Wisacheam Pharmaceutical Co., Ltd. 13817485796 tim@wisacheampharm.com China 3700 58
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
NanJing Xienuo bio Co.,Ltd. 025-84112752 13805181430 154301870@qq.com China 999 55
Supplier Advantage
ForeChem (Nantong) Technology Co.,Ltd. 61
Amatek Scientific Co. Ltd. 55
Bide Pharmatech Ltd. 60
Chengdu Firster Pharmaceutical Co., Ltd. 60
Shanghai Balmxy Pharmaceutical Co., Ltd 55
ShangHai AmK Pharmaceutical Technology Co., Ltd. 55
Shanghai Mayzem Pharmtech Co., Ltd. 56
ShangHai Wisacheam Pharmaceutical Co., Ltd. 58
Shanghai YuanYe Biotechnology Co., Ltd. 60
NanJing Xienuo bio Co.,Ltd. 55

View Latest Price from 2,4-Morpholinedicarboxylic acid, 4-(1,1-diMethylethyl) 2-Methyl ester manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2,4-Morpholinedicarboxylic acid, 4-(1,1-diMethylethyl) 2-Methyl ester pictures 2019-09-05 2,4-Morpholinedicarboxylic acid, 4-(1,1-diMethylethyl) 2-Methyl ester
500789-41-3
 $5.00 1KG 95%-98% 100kg Career Henan Chemical Co

2,4-Morpholinedicarboxylic acid, 4-(1,1-diMethylethyl) 2-Methyl ester Spectrum

2,4-Morpholinedicarboxylic acid, 4-(1,1-diMethylethyl) 2-Methyl ester(500789-41-3)1HNMR

500789-41-3 (2,4-Morpholinedicarboxylic acid, 4-(1,1-diMethylethyl) 2-Methyl ester) Related Search:

methyl morpholine-2-carboxylate hydrochloride 4-(Phenylmethyl)-2-morpholinecarboxylic acid methyl ester (S)-methyl morpholine-2-carboxylate hydrochloride (R)-methyl morpholine-2-carboxylate hydrochloride (S)-tert-butyl methyl morpholine-2,4-dicarboxylate
2-Morpholinecarboxylicacid,methylester(9CI)

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2,4-Morpholinedicarboxylic acid, 4-(1,1-diMethylethyl) 2-Methyl ester 4-Boc-Morpholine-2-carboxylic acid Methyl ester 4-(tert-Butyloxycarbonyl)morpholine-2-carboxylic acid methyl ester tert-butyl methyl morpholine-2,4-dicarboxylate methyl 4-Boc-morpholine-2-carboxylate Methyl N-Boc-2-morpholinecarboxylate 2,4-Morpholinedicarboxylic acid, 4-(1,1-dimethylethyl) 2-met... 4-(t-butyloxycarbonyl)morpholine-2-carboxylic acid methyl ester 4-O-tert-butyl 2-O-methyl morpholine-2,4-dicarboxylate 4-(tert-butoxycarbonyl)-2-MethylMorpholine-2-carboxylic acid 500789-41-3