4-Boc-2-morpholinecarboxylic acid
- CAS No.
- 189321-66-2
- Chemical Name:
- 4-Boc-2-morpholinecarboxylic acid
- Synonyms
- 4-(TERT-BUTOXYCARBONYL)MORPHOLINE-2-CARBOXYLIC ACID;BOC-COP-OH;BOC-COP;Boc-(R,S)-Cop-OH;RARECHEM EM WB 0087;Boc-2-carboxymorpholine;(R,S)-BOC-2-CARBOXYMORPHOLINE;BOC-(R,S)-2-CARBOXYMORPHOLINE;N-Boc-2-morpholinecarboxylic acid;4-Bocmorpholine-2-carboxylic acid
- CBNumber:
- CB2410841
- Molecular Formula:
- C10H17NO5
- Molecular Weight:
- 231.25
- MDL Number:
- MFCD01321006
- MOL File:
- 189321-66-2.mol
- MSDS File:
- SDS
| Melting point | >139oC (dec.) |
|---|---|
| Boiling point | 369.5±42.0 °C(Predicted) |
| Density | 1.230±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | DMSO (Slightly), Ethyl Acetate (Slightly, Heated) |
| form | Solid |
| pka | 3.25±0.20(Predicted) |
| color | Off-White to Pale Beige |
| InChI | InChI=1S/C10H17NO5/c1-10(2,3)16-9(14)11-4-5-15-7(6-11)8(12)13/h7H,4-6H2,1-3H3,(H,12,13) |
| InChIKey | LGWMTRPJZFEWCX-UHFFFAOYSA-N |
| SMILES | N1(C(OC(C)(C)C)=O)CCOC(C(O)=O)C1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P271-P280 |
| Hazard Codes | Xi |
| Risk Statements | 36-51 |
| Safety Statements | 26 |
| HS Code | 29334900 |
4-Boc-2-morpholinecarboxylic acid price More Price(79)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 265196 | Boc-(R,S)-2-carboxymorpholine | 189321-66-2 | 500mg | $333 | 2026-06-03 | Buy |
| Usbiological | 265196 | Boc-(R,S)-2-carboxymorpholine | 189321-66-2 | 1g | $470 | 2026-06-03 | Buy |
| Usbiological | 265196 | Boc-(R,S)-2-carboxymorpholine | 189321-66-2 | 2g | $632 | 2026-06-03 | Buy |
| Usbiological | 265196 | Boc-(R,S)-2-carboxymorpholine | 189321-66-2 | 5g | $894 | 2026-06-03 | Buy |
| Usbiological | 265196 | Boc-(R,S)-2-carboxymorpholine | 189321-66-2 | 10g | $1168 | 2026-06-03 | Buy |
4-Boc-2-morpholinecarboxylic acid Chemical Properties, Uses, Production
Chemical Properties
4-BOC-2-MORPHOLINECARBOXYLIC ACID is white to off-white powder
Uses
4-(1,1-Dimethylethyl) Ester 2,4-Morpholinedicarboxylic Acid is used in the preparation of potent and selective 3-phosphoinositide-dependent kinase 1 (PDK 1) inhibitors used in the treatment of multiple myelomas.
Uses
4-BOC-2-MORPHOLINECARBOXYLIC ACID is used in the preparation of potent and selective 3-phosphoinositide-dependent kinase 1 (PDK 1) inhibitors used in the treatment of multipl e myelomas.
Synthesis
500789-41-3
189321-66-2
Methyl 4-(tert-butoxycarbonyl)morpholine-2-carboxylate (251 mg, 1.02 mmol) was used as a raw material and dissolved in methanol (15 mL). To this solution was added 1 mol/L aqueous potassium hydroxide solution (3 mL). The reaction mixture was stirred at room temperature for 8 hours. Upon completion of the reaction, water was added to the mixture and the pH was adjusted with 5% aqueous citric acid solution. subsequently, the reaction mixture was extracted with ethyl acetate. The organic phase was washed with saturated brine and dried with anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to give 219 mg (93% yield) of the target product 4-Boc-2-morpholinecarboxylic acid as a colorless powder. The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ1.40 (9H, s), 2.70 (1H, dd, J=41.6,15.3 Hz), 3.03-3.09 (1H, m), 3.43-3.54 (2H, m), 3.78 (1H, m), 3.85 (1H, dt, J=11.6,3.7 Hz), 4.04 (1H, dd, J=8.6,3.7Hz), 12.73 (1H, brs).
References
[1] Patent: EP1780210, 2007, A1. Location in patent: Page/Page column 58
4-Boc-2-morpholinecarboxylic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaoyuan Technology (Shanghai) Co., Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 9985 | 58 |
| Nanbu County Chengxin Technology Co., Ltd. | 0838-5675166 15883665058 | nbcxkj@126.com | China | 956 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16306 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| China DongFan Chemical Co.,LTD | 86-0571-85151182 | China | 5681 | 66 |
View Latest Price from 4-Boc-2-morpholinecarboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-04 | 4-BOC-2-MORPHOLINECARBOXYLIC ACID
189321-66-2
|
1KG | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | ||
 |
2019-09-05 | 4-BOC-2-MORPHOLINECARBOXYLIC ACID
189321-66-2
|
$5.00 | 1KG | 95%-98% | 100kg | Career Henan Chemical Co |
-
- 4-BOC-2-MORPHOLINECARBOXYLIC ACID
189321-66-2
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 4-BOC-2-MORPHOLINECARBOXYLIC ACID
189321-66-2
- $5.00
- 95%-98%
- Career Henan Chemical Co
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