2-Hydroxymethyl-4-Boc-morpholine
- CAS No.
- 135065-69-9
- Chemical Name:
- 2-Hydroxymethyl-4-Boc-morpholine
- Synonyms
- TERT-BUTYL 2-(HYDROXYMETHYL)MORPHOLINE-4-CARBOXYLATE;2-Hydroxymethyl-morpholine-4-carboxylic acid tert-butyl ester;Viloxazine Impurity 3;Boc-2-hydroxymethyl-morpholine;4-Boc-2-hydroxymethyl-morpholine;2-Hydroxymethyl-4-Boc-morpholine;N-BOC-2-(HYDROXYMETHYL)MORPHOLINE;4-N-BOC-2-HYDROXYMETHYLMORPHOLINE;N-tert-Butoxycarbonyl-2-(hydroxymethyl)morpholine;tert-Butyl 2-(hydroxymethyl)-4-morpholinecarboxylate
- CBNumber:
- CB1171695
- Molecular Formula:
- C10H19NO4
- Molecular Weight:
- 217.26
- MDL Number:
- MFCD03426270
- MOL File:
- 135065-69-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 320.7±27.0 °C(Predicted) |
|---|---|
| Density | 1.118±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Dichloromethane, Ether, Ethyl Acetate, |
| form | Oil |
| pka | 14.36±0.10(Predicted) |
| color | Colourless |
| CAS DataBase Reference | 135065-69-9(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HazardClass | IRRITANT |
| HS Code | 2934999090 |
2-Hydroxymethyl-4-Boc-morpholine price More Price(66)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AstaTech | 55953 | 4-BOC-2-HYDROXYMETHYL-MORPHOLINE 95% | 135065-69-9 | 1G | $12 | 2026-04-30 | Buy |
| AstaTech | 55953 | 4-BOC-2-HYDROXYMETHYL-MORPHOLINE 95% | 135065-69-9 | 5G | $19 | 2026-04-30 | Buy |
| AstaTech | 55953 | 4-BOC-2-HYDROXYMETHYL-MORPHOLINE 95% | 135065-69-9 | 25G | $81 | 2026-04-30 | Buy |
| Biosynth | KFA06569 | N-Boc-2-hydroxymethylmorpholine | 135065-69-9 | 5g | $312.5 | 2026-06-04 | Buy |
| Biosynth | KFA06569 | N-Boc-2-hydroxymethylmorpholine | 135065-69-9 | 50g | $1875 | 2026-06-04 | Buy |
2-Hydroxymethyl-4-Boc-morpholine Chemical Properties, Uses, Production
Chemical Properties
Colourless Oil
Uses
Intermediate in the preparation of racemic analogs of Viloxazine.
Synthesis
24424-99-5
40987-24-4
135065-69-9
GENERAL STEPS: Ammonium formate (3.04 g, 48.2 mmol) and 10% palladium/activated charcoal (500 mg) were added to a methanolic solution (50 mL) of (4-benzylmorpholin-2-yl)methanol (1.00 g, 4.82 mmol). The reaction mixture was stirred at room temperature for 4 hours. After completion of the reaction, the mixture was filtered through diatomaceous earth and the filtrate was concentrated under reduced pressure. The resulting residue was dissolved in acetonitrile (20 mL) and cooled in an ice bath. To this solution, di-tert-butyl dicarbonate (1.58 g, 7.23 mmol) and triethylamine (1.35 mL, 9.64 mmol) were added sequentially and the reaction mixture was stirred at room temperature for 3 hours. At the end of the reaction, the solvent was evaporated under reduced pressure, water was added to the residue and extracted with ethyl acetate. The organic phases were combined, washed with saturated brine, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (eluent: hexane/ethyl acetate=5:1→1:1) to afford the target compound tert-butyl 2-(hydroxymethyl)morpholine-4-carboxylate (907 mg, 87% yield) as a colorless oil.1H NMR (400 MHz, DMSO-d6) δ 1.40 (9H, s), 2.47-2.66 (1H, m), and 2.73-2.92 (1H, m), 3.25-3.45 (4H, m), 3.70 (1H, d, J=13.4 Hz), 3.79 (1H, dd, J=11.6, 2.4 Hz), 3.85 (1H, d, J=12.8 Hz), 4.77 (1H, t, J=5.5 Hz).
References
[1] Patent: US2004/192653, 2004, A1
[2] Patent: EP1780210, 2007, A1. Location in patent: Page/Page column 55-56
[3] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 17, p. 4080 - 4083
2-Hydroxymethyl-4-Boc-morpholine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| PharmaBlock Sciences (Nanjing),Inc. | 025-86918202 4000255188 | sales@pharmablock.com | China | 5000 | 55 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| ForeChem (Nantong) Technology Co.,Ltd. | 513-85982855 18921614129 | sales@xianxingpharm.com | China | 2712 | 61 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Tetranov Biopharm | 13526569071 | sales@leadmedpharm.com | China | 7881 | 64 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
View Latest Price from 2-Hydroxymethyl-4-Boc-morpholine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2022-01-26 | tert-Butyl 2-(hydroxymethyl)morpholine-4-carboxylate
135065-69-9
|
1KG | 98.4% | 100 tons | Honest Joy Holdings Limited | ||
 |
2021-08-12 | 2-HYDROXYMETHYL-4-BOC-MORPHOLINE
135065-69-9
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2019-07-06 | 2-HYDROXYMETHYL-4-BOC-MORPHOLINE
135065-69-9
|
$7.00 | 1KG | 99% | 1000KG | Career Henan Chemical Co |
-
- tert-Butyl 2-(hydroxymethyl)morpholine-4-carboxylate
135065-69-9
- $0.00
- 98.4%
- Honest Joy Holdings Limited
-
- 2-HYDROXYMETHYL-4-BOC-MORPHOLINE
135065-69-9
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 2-HYDROXYMETHYL-4-BOC-MORPHOLINE
135065-69-9
- $7.00
- 99%
- Career Henan Chemical Co
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