(S)-2-(1-aMinopropyl)-5-fluoro-3-phenylquinazolin-4(3H)-one
- CAS No.
- 870281-86-0
- Chemical Name:
- (S)-2-(1-aMinopropyl)-5-fluoro-3-phenylquinazolin-4(3H)-one
- Synonyms
- (S)-2-(1-((9H-purin-6-yl-2,8-d2)amino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one;CAL10;CAL-101(N-1);Idelalisib INT;IdelalisibIntermediates 1;CAL-101 (N-1) Intermediate;(S)-2-(1-aMinopropyl)-5-fluoro-3-phenylquinazolin-4(3H)-one;2-[(1S)-1-Aminopropyl]-5-fluoro-3-phenyl-4(3H)-quinazolinone;4(3H)-Quinazolinone, 2-[(1S)-1-aminopropyl]-5-fluoro-3-phenyl-;2-[(1S)-1-aminopropyl]-5-fluoro-3-phenyl-3,4-dihydroquinazolin-4-one
- CBNumber:
- CB42623630
- Molecular Formula:
- C17H16FN3O
- Molecular Weight:
- 297.33
- MDL Number:
- MFCD22124614
- MOL File:
- 870281-86-0.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 2-[(1S)-1-Aminoprpyl]-5-fluoro-3-phenyl-4(3H)-quinazolinone | TRC-A628755-500MG | 500mg | $167 |
| 2-[(1S)-1-Aminoprpyl]-5-fluoro-3-phenyl-4(3H)-quinazolinone | TRC-A628755-1G | 1g | $227 |
| 2-[(1S)-1-Aminoprpyl]-5-fluoro-3-phenyl-4(3H)-quinazolinone | TRC-A628755-100MG | 100mg | $123 |
| 2-[(1S)-1-Aminopropyl]-5-fluoro-3-phenyl-4(3H)-quinazolinone | FA96431 | 0.5g | $150 |
| 2-[(1S)-1-Aminopropyl]-5-fluoro-3-phenyl-4(3H)-quinazolinone | FA96431 | 1g | $220 |
| More product size | |||
| Boiling point | 455.3±55.0 °C(Predicted) |
|---|---|
| Density | 1.27±0.1 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| solubility | Chloroform (Slightly), DMSO (Slightly), Ethanol (Sparingly) |
| pka | 8.23±0.29(Predicted) |
| form | Solid |
| color | Off-White |
| InChI | InChI=1S/C17H16FN3O/c1-2-13(19)16-20-14-10-6-9-12(18)15(14)17(22)21(16)11-7-4-3-5-8-11/h3-10,13H,2,19H2,1H3/t13-/m0/s1 |
| InChIKey | BNMGOWXQUZHWIO-ZDUSSCGKSA-N |
| SMILES | N1C2=C(C(F)=CC=C2)C(=O)N(C2=CC=CC=C2)C=1[C@@H](N)CC |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
(S)-2-(1-aMinopropyl)-5-fluoro-3-phenylquinazolin-4(3H)-one price More Price(35)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-A628755-500MG | 2-[(1S)-1-Aminoprpyl]-5-fluoro-3-phenyl-4(3H)-quinazolinone | 870281-86-0 | 500mg | $167 | 2026-06-03 | Buy |
| TRC | TRC-A628755-1G | 2-[(1S)-1-Aminoprpyl]-5-fluoro-3-phenyl-4(3H)-quinazolinone | 870281-86-0 | 1g | $227 | 2026-06-03 | Buy |
| TRC | TRC-A628755-100MG | 2-[(1S)-1-Aminoprpyl]-5-fluoro-3-phenyl-4(3H)-quinazolinone | 870281-86-0 | 100mg | $123 | 2026-06-03 | Buy |
| Biosynth | FA96431 | 2-[(1S)-1-Aminopropyl]-5-fluoro-3-phenyl-4(3H)-quinazolinone | 870281-86-0 | 0.5g | $150 | 2026-06-04 | Buy |
| Biosynth | FA96431 | 2-[(1S)-1-Aminopropyl]-5-fluoro-3-phenyl-4(3H)-quinazolinone | 870281-86-0 | 1g | $220 | 2026-06-04 | Buy |
(S)-2-(1-aMinopropyl)-5-fluoro-3-phenylquinazolin-4(3H)-one Chemical Properties,Uses,Production
Uses
2-[(1S)-1-Aminoprpyl]-5-fluoro-3-phenyl-4(3H)-quinazolinone is used as reagent/reactant in synthetic preparation of idelalisib using the HMDS/I2-catalyzed cyclocondensation and Boc deprotection of an (aminobutyrylamino)benzamide to a nonracemic quinazoline as the key step.
Synthesis
870281-85-9
870281-86-0
The general procedure for the synthesis of (S)-2-(1-aminopropyl)-5-fluoro-3-phenyl-4(3H)-quinazolinone from tert-butyl (S)-(1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbamate was carried out as follows: the (S)-(1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl )propyl)carbamic acid tert-butyl ester (220 mg, 0.55 mmol) was dissolved in ethyl acetate (2 mL), followed by a one-time addition of an ethyl acetate solution of hydrogen chloride (2.5 mL, 3.88 M) at room temperature. The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the resulting suspension was dissolved in water (20 mL) and the aqueous phase was extracted with ethyl acetate (20 mL) and the pH of the aqueous phase was adjusted with sodium carbonate powder to 8. Subsequently, the aqueous phase was further extracted with ethyl acetate (20 mL x 3). All organic phases were combined, washed with saturated saline (20 mL), dried over anhydrous sodium sulfate, and concentrated under reduced pressure to afford (S)-2-(1-aminopropyl)-5-fluoro-3-phenyl-4(3H)-quinazolinone as a white powder (163 mg, 100% yield).
References
[1] Patent: CN104513235, 2017, B. Location in patent: Paragraph 1158; 1159; 1160; 1161
[2] Patent: CN104130261, 2016, B. Location in patent: Paragraph 0042; 0043; 0044
[3] Patent: WO2005/113554, 2005, A2. Location in patent: Page/Page column 25
[4] Patent: CN106146411, 2016, A. Location in patent: Paragraph 0035; 0036
[5] Organic Preparations and Procedures International, 2016, vol. 48, # 4, p. 337 - 341
(S)-2-(1-aMinopropyl)-5-fluoro-3-phenylquinazolin-4(3H)-one Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changzhou Rokechem Technology Co., Ltd. | 18758118018 | sales001@rokechem.com | China | 255 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Fluoropharm Co., Ltd. | +86-0571-85586753 +86-13336034509 | sales@fluoropharm.com | China | 1445 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Lianyungang happen teng technology co., LTD | 15950718863 | wang666xt@163.com | CHINA | 295 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 965 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19936 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Shanghai Yingrui Biopharma Co.,Ltd | 21-33585366 | export01@shyrchem.com | CHINA | 1319 | 58 |
View Lastest Price from (S)-2-(1-aMinopropyl)-5-fluoro-3-phenylquinazolin-4(3H)-one manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-04-04 | (S)-2-(1-aMinopropyl)-5-fluoro-3-phenylquinazolin-4(3H)-one
870281-86-0
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | ||
 |
2022-08-16 | (S)-2-(1-aMinopropyl)-5-fluoro-3-phenylquinazolin-4(3H)-one
870281-86-0
|
1kg | 99%min | 1-50kg | Changzhou Rokechem Technology Co., Ltd. | ||
 |
2019-07-06 | (S)-2-(1-aMinopropyl)-5-fluoro-3-phenylquinazolin-4(3H)-one
870281-86-0
|
$1.00 | 1KG | 98% | 100KG | Career Henan Chemical Co |
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- (S)-2-(1-aMinopropyl)-5-fluoro-3-phenylquinazolin-4(3H)-one
870281-86-0
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- (S)-2-(1-aMinopropyl)-5-fluoro-3-phenylquinazolin-4(3H)-one
870281-86-0
- $0.00
- 99%min
- Changzhou Rokechem Technology Co., Ltd.
-
- (S)-2-(1-aMinopropyl)-5-fluoro-3-phenylquinazolin-4(3H)-one
870281-86-0
- $1.00
- 98%
- Career Henan Chemical Co
