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ChemicalBook >> CAS DataBase List >>2-(2,6-dioxopiperidin-3-yl)-4-nitroisoindoline-1,3-dione

2-(2,6-dioxopiperidin-3-yl)-4-nitroisoindoline-1,3-dione

2-(2,6-dioxopiperidin-3-yl)-4-nitroisoindoline-1,3-dione Structure
2-(2,6-dioxopiperidin-3-yl)-4-nitroisoindoline-1,3-dione structure
CAS No.
19171-18-7
Chemical Name:
2-(2,6-dioxopiperidin-3-yl)-4-nitroisoindoline-1,3-dione
Synonyms
4-Nitrothalidomide;Pomadomide impurity 9;Pomalidomide Impurity E;Pomalidomide Intermediates;Thalidomide 4-Nitro Impurity;2-(2,6-dioxopiperidin-3-yl)-4-nitroisoindole-1,3-dione;2-(2,6-Dioxo-3-piperidyl)-4-nitroisoindoline-1,3-dione;2-(2,6-dioxopiperidin-3-yl)-4-nitroisoindoline-1,3-dione;4-nitro-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;(R)-2-(2,6-Dioxopiperidin-3-yl)-4-nitroisoindoline-1,3-dione
CBNumber:
CB42623812
Molecular Formula:
C13H9N3O6
Molecular Weight:
303.23
MDL Number:
MFCD01748356
MOL File:
19171-18-7.mol
MSDS File:
SDS
Last updated:2026-05-28 03:39:50
Product description Number Pack Size Price
4-Nitrothalidomide TRC-N565525-5MG 5mg $89
4-Nitrothalidomide TRC-N565525-50MG 50mg $119
4-Nitrothalidomide TRC-N565525-250MG 250mg $137
2-(2,6Dioxopiperidin-3-yl)-4-nitroisoindoline-1,3-dione FD165191 100g $900
Nitrothalidomide bp-40451 5G $110
More product size
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2-(2,6-dioxopiperidin-3-yl)-4-nitroisoindoline-1,3-dione Properties

Melting point >200°C (dec.)
Boiling point 603.4±50.0 °C(Predicted)
Density 1.651±0.06 g/cm3(Predicted)
storage temp. Inert atmosphere,Room Temperature
solubility Acetonitrile (Slightly, Heated, Sonicated), DMSO (Slightly)
pka 10.55±0.40(Predicted)
form Solid
color Pale Yellow to Pale Beige
InChI InChI=1S/C13H9N3O6/c17-9-5-4-8(11(18)14-9)15-12(19)6-2-1-3-7(16(21)22)10(6)13(15)20/h1-3,8H,4-5H2,(H,14,17,18)
InChIKey KVRCAGKHAZRSQX-UHFFFAOYSA-N
SMILES C1(=O)C2=C(C([N+]([O-])=O)=CC=C2)C(=O)N1C1CCC(=O)NC1=O
FDA UNII OH13HKS17A

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

2-(2,6-dioxopiperidin-3-yl)-4-nitroisoindoline-1,3-dione price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC TRC-N565525-5MG 4-Nitrothalidomide 19171-18-7 5mg $89 2026-06-03 Buy
TRC TRC-N565525-50MG 4-Nitrothalidomide 19171-18-7 50mg $119 2026-06-03 Buy
TRC TRC-N565525-250MG 4-Nitrothalidomide 19171-18-7 250mg $137 2026-06-03 Buy
Biosynth FD165191 2-(2,6Dioxopiperidin-3-yl)-4-nitroisoindoline-1,3-dione 19171-18-7 100g $900 2026-06-04 Buy
BroadPharm bp-40451 Nitrothalidomide 19171-18-7 5G $110 2026-05-24 Buy
Product number Packaging Price Buy
TRC-N565525-5MG 5mg $89 Buy
TRC-N565525-50MG 50mg $119 Buy
TRC-N565525-250MG 250mg $137 Buy
FD165191 100g $900 Buy
bp-40451 5G $110 Buy

2-(2,6-dioxopiperidin-3-yl)-4-nitroisoindoline-1,3-dione Chemical Properties,Uses,Production

Uses

4-Nitrothalidomide is a compound involved in the preparation of Pomalidomide (P688200), a thalidomide derivative and potent inhibitor of TNF-α production.

Synthesis

3-Nitrophthalic anhydride

641-70-3

2,6-Dioxopiperidine-3-ammonium chloride

24666-56-6

2-(2,6-dioxopiperidin-3-yl)-4-nitroisoindoline-1,3-dione

19171-18-7

A solution of glacial acetic acid (75 mL) and 3-aminopiperidine-2,6-dione hydrochloride (8.5 g) was added to a round bottom flask. Anhydrous sodium acetate (4.5 g) was added to the solution in batches at 25 °C to 30 °C, followed by 3-nitrophthalic anhydride (10 g) at the same temperature. The reaction mixture was stirred at 118 °C for 18 hours. After completion of the reaction, the reaction material was cooled to 60 °C and the solvent was removed by distillation under vacuum to obtain a residue. Water (100 mL) was added to the residue and the mixture was stirred at 25 °C to 30 °C for 1 hour, followed by filtration. The wet filter cake was slurried with water (100 mL x 2), filtered and dried in an air pan drier to less than 0.5% water to give 2-(2,6-dioxopiperidin-3-yl)-4-nitroisoindoline-1,3-dione (14 g). Yield: 89.7%, purity: 98%.

References

[1] Patent: US2017/260157, 2017, A1. Location in patent: Page/Page column 5
[2] Patent: CN104926786, 2017, B. Location in patent: Paragraph 0044; 0045
[3] Synthetic Communications, 2016, vol. 46, # 16, p. 1343 - 1348
[4] Bioorganic and Medicinal Chemistry Letters, 1999, vol. 9, # 11, p. 1625 - 1630
[5] Patent: CN104402863, 2016, B. Location in patent: Paragraph 0035

2-(2,6-dioxopiperidin-3-yl)-4-nitroisoindoline-1,3-dione Preparation Products And Raw materials

Raw materials

3-Nitrophthalic acid 2-(2,6-Dioxotetrahydro-2H-pyran-3-yl)-4-nitroisoindoline-1,3-dione 3-Nitrophthalimide 3-Nitrophthalic anhydride 2,6-Dioxopiperidine-3-ammonium chloride

Preparation Products

Pomalidomide

2-(2,6-dioxopiperidin-3-yl)-4-nitroisoindoline-1,3-dione Suppliers

Global( 120)Suppliers
Supplier Tel Email Country ProdList Advantage
ShenZhen H&D Pharmaceutical Technology Co., LTD 		+86-18627948422 sale@hdimpurity.com China 3676 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29626 60
career henan chemical co 		+86-0371-86658258 factory@coreychem.com China 29780 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418671 +86-189 4982 3763 sales@tnjchem.com China 34526 58
AFINE CHEMICALS LIMITED 		+86-571-85134551 +86-18958018566 info@afinechem.com China 15050 58
HANGZHOU LEAP CHEM CO., LTD. 		+86-571-87711850 +8619957148339 market18@leapchem.com China 24569 58
Zibo Hangyu Biotechnology Development Co., Ltd 		+86-0533-2185556 +86-15965530500 nickzhang@hangyubiotech.com China 9930 58
Shanghai Acmec Biochemical Technology Co., Ltd. 		+86-18621343501 product@acmec-e.com China 33301 58
Aladdin Scientific 		tp@aladdinsci.com United States 54746 58
Suzhou ARTK Medchem Co., Ltd. 		+86-18168183658 sales1@artkmedchem.com China 39007 58
Supplier Advantage
ShenZhen H&D Pharmaceutical Technology Co., LTD 		58
Capot Chemical Co.,Ltd. 		60
career henan chemical co 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58
AFINE CHEMICALS LIMITED 		58
HANGZHOU LEAP CHEM CO., LTD. 		58
Zibo Hangyu Biotechnology Development Co., Ltd 		58
Shanghai Acmec Biochemical Technology Co., Ltd. 		58
Aladdin Scientific 		58
Suzhou ARTK Medchem Co., Ltd. 		58

View Lastest Price from 2-(2,6-dioxopiperidin-3-yl)-4-nitroisoindoline-1,3-dione manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Pomalidomide Impurity 9 pictures 2026-03-12 Pomalidomide Impurity 9
19171-18-7
 10mg 98% 500mg ShenZhen H&D Pharmaceutical Technology Co., LTD
Pomalidomide Impurity 10 pictures 2026-03-12 Pomalidomide Impurity 10
19171-18-7
 10mg 98% 500mg ShenZhen H&D Pharmaceutical Technology Co., LTD
2-(2,6-dioxopiperidin-3-yl)-4-nitroisoindoline-1,3-dione pictures 2020-01-03 2-(2,6-dioxopiperidin-3-yl)-4-nitroisoindoline-1,3-dione
19171-18-7
 $1.00 1KG 95-99% 1ton Career Henan Chemical Co

2-(2,6-dioxopiperidin-3-yl)-4-nitroisoindoline-1,3-dione Spectrum

2-(2,6-dioxopiperidin-3-yl)-4-nitroisoindoline-1,3-dione(19171-18-7)1HNMR

19171-18-7(2-(2,6-dioxopiperidin-3-yl)-4-nitroisoindoline-1,3-dione)Related Search:

Pomalidomide Impurity 4 3-AMINOPHTHALIC ACID (R)-Pomalidomide 5-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Pomalidomide Impurity 10
3,4-Diamino-4-oxobutyric acid DL-Glutamine (S)-Pomalidomide 2-(2,6-dioxopiperidin-3-yl)-4-(hydroxyamino)isoindoline-1,3-dione 3-Nitrophthalic acid
Pomalidomide Impurity 2 Pomalidomide Impurity 6 Thalidomide 4-Hydroxy ThalidoMide Pomalidomide
Pomalidomide Impurity 3 3-AMINOPHTHALIC ACID HYDROCHLORIDE 4-Aminophthalic acid

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2-(2,6-dioxopiperidin-3-yl)-4-nitroisoindoline-1,3-dione 4-Nitrothalidomide Pomalidomide Intermediates Pomalidomide Impurity E 4-nitro-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione 2-(2,6-dioxopiperidin-3-yl)-4-nitroisoindole-1,3-dione Thalidomide 4-Nitro Impurity 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-nitro- (R)-2-(2,6-Dioxopiperidin-3-yl)-4-nitroisoindoline-1,3-dione 2-(2,6-dioxopiperidin-3-yl)-4-nitro-1H-isoindole-1,3(2H)-dione 2-(2,6-dioxopiperidin-3-yl)-4-nitro-1H-isoindole-1,3(2H)-dio... 2-(2,6-Dioxo-3-piperidyl)-4-nitroisoindoline-1,3-dione Pomadomide impurity 9 2-(2,6-Dioxo-3-piperidinyl)-4-nitro-1H-isoindole-1,3(2H)-dione 19171-18-7