3-Nitrophthalic acid
- CAS No.
- 603-11-2
- Chemical Name:
- 3-Nitrophthalic acid
- Synonyms
- 3-NPA;o-Nitrophthalic acid;Pomalidomide Impurity 8;3-nitro-1,2-benzenedicarboxylic acid;NSC 3120;AKOS B028734;3-nitrophthalic;3-nitro-phthalate;RARECHEM AL BO 0803;m-Nitrophthalic acid
- CBNumber:
- CB5323089
- Molecular Formula:
- C8H5NO6
- Molecular Weight:
- 211.13
- MDL Number:
- MFCD00007138
- MOL File:
- 603-11-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 210 °C (dec.) (lit.) |
|---|---|
| Boiling point | 350.79°C (rough estimate) |
| Density | 1.6342 (rough estimate) |
| vapor density | 7.3 (vs air) |
| refractive index | 1.5282 (estimate) |
| storage temp. | Store below +30°C. |
| solubility | water: soluble5%, clear to slightly hazy, colorless to faint yellow or tan |
| pka | pK1:1.88 (25°C) |
| form | Powder |
| color | Off-white to light yellow |
| Water Solubility | 20 g/L (25 ºC) |
| Decomposition | 216 °C |
| BRN | 2054269 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| InChI | 1S/C8H5NO6/c10-7(11)4-2-1-3-5(9(14)15)6(4)8(12)13/h1-3H,(H,10,11)(H,12,13) |
| InChIKey | KFIRODWJCYBBHY-UHFFFAOYSA-N |
| SMILES | OC(=O)c1cccc(c1C(O)=O)[N+]([O-])=O |
| CAS DataBase Reference | 603-11-2(CAS DataBase Reference) |
| FDA UNII | MC7W4GB97C |
| NIST Chemistry Reference | 3-Nitrophthalic acid(603-11-2) |
| EPA Substance Registry System | 3-Nitrophthalic acid (603-11-2) |
| UNSPSC Code | 12352106 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H315-H318-H335 | |||||||||
| Precautionary statements | P261-P280-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38-41 | |||||||||
| Safety Statements | 26-36/39-37/39-36 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29173980 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Dam. 1 Skin Irrit. 2 STOT SE 3 |
|||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
3-Nitrophthalic acid price More Price(64)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 369306 | 3-Nitrophthalic acid 95% | 603-11-2 | 100g | $65.1 | 2026-04-30 | Buy |
| Sigma-Aldrich | 137820 | 3-Nitrophthalic acid 99% | 603-11-2 | 100g | $158 | 2026-04-30 | Buy |
| TCI Chemical | N0243 | 3-Nitrophthalic Acid >98.0%(HPLC)(T) | 603-11-2 | 25g | $31 | 2026-04-30 | Buy |
| TCI Chemical | N0243 | 3-Nitrophthalic Acid >98.0%(HPLC)(T) | 603-11-2 | 500g | $140 | 2026-04-30 | Buy |
| Usbiological | 285439 | 3-Nitrophthalic acid ≥98.5% | 603-11-2 | 500g | $333 | 2026-06-03 | Buy |
3-Nitrophthalic acid Chemical Properties,Uses,Production
Chemical Properties
Pale yellow crystals. soluble in hot water, methanol, ethanol, slightly soluble in ether, insoluble in chloroform, carbon tetrachloride, carbon disulfide, benzene.
Uses
3-Nitrophthalic Acid is a useful chemical in organic synthesis. It is also an impurity of Apremilast.
Uses
3-Nitrophthalic acid may be used as starting reagent in the synthesis of modified 2-iodoxybenzoic acid derivatives. It may be used in the synthesis of brucinium 2-carboxy-6-nitrophthalate dihydrate (systematic name: 2,3-dimethoxy-10-oxostrychnidinium 2-carboxy-6-nitrophthalate dihydrate), via heating with brucine.
Preparation
Phthalic anhydride was added to concentrated sulfuric acid, stirring under the passage of water vapor heating to 80 °C, fuming nitric acid was added dropwise, the reaction temperature to maintain 100-110°C, add the end of the heat above 110°C for 2h, placed in the overnight pour into the water, and filtered. The filter cake was recrystallized with water to obtain 3-Nitrophthalic acid. Yield of about 30%.
Synthesis Reference(s)
The Journal of Organic Chemistry, 39, p. 2468, 1974 DOI: 10.1021/jo00930a051
General Description
3-Nitrophthalic acid is a degradation product of isoxaben herbicide. It acts as ligand and forms rare-earth complexes.
Safety Profile
A preparative hazard. When heated to decomposition it emits toxic fumes of NOx.
Purification Methods
Crystallise 3-nitrophthalic acid from hot water (1.5mL/g). Dry it in air. The amide has m 201o (from EtOH). [Beilstein 9 H 823, 9 IV 3275.]
3-Nitrophthalic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Beijing Century Richap Chemistry Co., Ltd. | 010-64446226 13146983882 | info@bj-newcenturychem.com | China | 111 | 55 |
| ZHEJIANG ZETIAN FINE CHEMICALS CO.,LTD | 0571-87322520 18957127338 | sales@zetchem.com | China | 466 | 55 |
| Shanxi Libolong New Materials Co., Ltd | 19135980588 | 13935924147@163.cn | China | 17 | 58 |
| ZhengZhou HuaWen Chemical Co.Ltd | 0370-2785118 17550508557 | 675141927@qq.com | China | 3201 | 55 |
| Changzhou Zeyuan Pharmaceutical Technology Co., Ltd | 19026388314 | 2589694173@qq.com | China | 164 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| future industrial shanghai co., ltd | 400-0066400 13621662912 | sales@jonln.com | China | 1989 | 65 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TAIYUAN RHF CO.,LTD. | +86 351 7031519 | sales@RHFChem.com | China | 2334 | 56 |
Related articles
- 3-Nitrophthalic Acid: A Key Compound in Organic Synthesis
- 3-Nitrophthalic acid can be used as starting reagent in the synthesis of modified 2-iodoxybenzoic acid derivatives.
- Mar 21,2025
View Lastest Price from 3-Nitrophthalic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-11 | 3-Nitrophthalic acid
603-11-2
|
$666.00-999.00 | 1kg | 99% | 5000 | HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | |
 |
2026-09-11 | 3-Nitrophthalic acid
603-11-2
|
$12.56 | 25Kg/Drum | 99.5%HPLC | 20tons/month | Asia Chem I and E (Jiangsu) Co Ltd | |
 |
2026-09-02 | 3-Nitrophthalic acid
603-11-2
|
$1.00-100.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd |
-
- 3-Nitrophthalic acid
603-11-2
- $666.00-999.00
- 99%
- HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
-
- 3-Nitrophthalic acid
603-11-2
- $12.56
- 99.5%HPLC
- Asia Chem I and E (Jiangsu) Co Ltd
-
- 3-Nitrophthalic acid
603-11-2
- $1.00-100.00
- 99%
- Henan Fengda Chemical Co., Ltd
