LY 2140023
- CAS No.
- 635318-55-7
- Chemical Name:
- LY 2140023
- Synonyms
- PoMagluMetad Methionil;LY2140023 monohydrate;VOYCNOJFAJAILW-CAMHOICYSA-N;Pomaglumetad methionil anhydrous;2-Thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid, 4-[[(2S)-2-amino-4-(methylthio)-1-oxobutyl]amino]-, 2,2-dioxide, (1R,4S,5S,6S)-
- CBNumber:
- CB42628059
- Molecular Formula:
- C12H18N2O7S2
- Molecular Weight:
- 366.41
- MDL Number:
- MFCD32661884
- MOL File:
- 635318-55-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 203 °C |
|---|---|
| Boiling point | 773.6±60.0 °C(Predicted) |
| Density | 1+-.0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility |
DMSO: 0.25mg/mL dilute NaOH: 10mg/mL |
| pka | 2.14±0.40(Predicted) |
| form | powder |
| color | white |
| InChI | 1S/C12H18N2O7S2/c1-22-3-2-5(13)9(15)14-12(11(18)19)4-23(20,21)8-6(7(8)12)10(16)17/h5-8H,2-4,13H2,1H3,(H,14,15)(H,16,17)(H,18,19)/t5-,6+,7+,8-,12+/m0/s1 |
| InChIKey | VOYCNOJFAJAILW-OZFRBSTCSA-N |
| FDA UNII | 3V85EZ3KFQ |
| UNSPSC Code | 12352200 |
LY 2140023 price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 5.04466 | LY-404,039 - CAS 635318-55-7 - Calbiochem | 635318-55-7 | 5MG | $129 | 2023-01-07 | Buy |
| Usbiological | 281342 | LY404039 Asreported | 635318-55-7 | 2mg | $352 | 2026-06-03 | Buy |
| Usbiological | 281342 | LY404039 Asreported | 635318-55-7 | 5mg | $468 | 2026-06-03 | Buy |
| Usbiological | 281342 | LY404039 Asreported | 635318-55-7 | 10mg | $656 | 2026-06-03 | Buy |
| Usbiological | 281342 | LY404039 Asreported | 635318-55-7 | 25mg | $1018 | 2026-06-03 | Buy |
LY 2140023 Chemical Properties,Uses,Production
Uses
LY 2140023 is a drug developed as a treatment option for schizophrenia. It targets the mGlu2/3 receptor once metabolized.
Biological Activity
Primary Target
mGlu2 & mGlu3', 'Target Ki: 149 nM and 92 nM for human mGlu2 and mGlu3, respectively.
in vivo
Pomaglumetad methionil (LY2140023; orally; 3-300 mg/kg; once daily for 7 days) dose-dependent increases the levels of the dopamine metabolites dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA)[1].
| Animal Model: | Male Fischer rats (approximately 250 g)[1] |
| Dosage: | 3, 10, and 300 mg/kg |
| Administration: | Orally; once daily for 7 days |
| Result: | Dose-dependent increased the levels of the dopamine metabolites DOPAC and HVA. |
IC 50
mGluR2; mGluR3
LY 2140023 Preparation Products And Raw materials
Raw materials
Preparation Products
LY 2140023 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| NCE Biomedical Co.,Ltd. | 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 | China | 1490 | 55 | |
| LETOPHARM LIMITED | +86-21-5821 5861 | sales@letopharm.com | China | 2374 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Chunchuang (Wuhan) Technology Co., Ltd | 15727060112 | yutianchun2007@126.com | China | 9867 | 58 |
| cjbscvictory | 13348960310 13348960310 | 3003867561@qq.com | China | 10233 | 58 |
| Abmole Bioscience Inc. | 19821158099 | sales@abmole.cn | China | 4485 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Supplier | Advantage |
|---|---|
| BOC Sciences | 65 |
| NCE Biomedical Co.,Ltd. | 55 |
| LETOPHARM LIMITED | 58 |
| TargetMol Chemicals Inc. | 58 |
| Chunchuang (Wuhan) Technology Co., Ltd | 58 |
| cjbscvictory | 58 |
| Abmole Bioscience Inc. | 58 |
| TargetMol Chemicals Inc. | 58 |
