8-(2-Ethoxyphenyl)-7,8-dihydro-1,3-Dioxolo[4,5-g]quinolin-6(5H)-one
![8-(2-Ethoxyphenyl)-7,8-dihydro-1,3-Dioxolo[4,5-g]quinolin-6(5H)-one Structure](CAS/20180702/GIF/599151-35-6.gif)
- CAS No.
- 599151-35-6
- Chemical Name:
- 8-(2-Ethoxyphenyl)-7,8-dihydro-1,3-Dioxolo[4,5-g]quinolin-6(5H)-one
- Synonyms
- FQI1;FQI1 (FQI 1);FQI1 >=98% (HPLC);8-(2-ethoxyphenyl)-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]quinolin-6-one;8-(2-Ethoxyphenyl)-7,8-dihydro-1,3-Dioxolo[4,5-g]quinolin-6(5H)-one;1,3-Dioxolo[4,5-g]quinolin-6(5H)-one, 8-(2-ethoxyphenyl)-7,8-dihydro-
- CBNumber:
- CB42750581
- Molecular Formula:
- C18H17NO4
- Molecular Weight:
- 311.33
- MDL Number:
- MFCD03632583
- MOL File:
- 599151-35-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 463.6±45.0 °C(Predicted) |
|---|---|
| Density | 1.272±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble10mg/mL (clear solution) |
| form | powder |
| pka | 13.36±0.40(Predicted) |
| color | white to beige |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| InChI | 1S/C18H17NO4/c1-2-21-15-6-4-3-5-11(15)12-8-18(20)19-14-9-17-16(7-13(12)14)22-10-23-17/h3-7,9,12H,2,8,10H2,1H3,(H,19,20) |
| InChIKey | YKSYGLXHLSPWLB-UHFFFAOYSA-N |
| SMILES | O=C1CC(C2=CC=CC=C2OCC)C3=CC4=C(OCO4)C=C3N1 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H400 | |||||||||
| Precautionary statements | P273-P301+P310 | |||||||||
| Hazard Codes | T,N | |||||||||
| Risk Statements | 25-50 | |||||||||
| Safety Statements | 45-61 | |||||||||
| RIDADR | UN2811 - class 6.1 - PG 3 - EHS - Toxic solids, organic, n.o.s., HI: all | |||||||||
| WGK Germany | 3 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
8-(2-Ethoxyphenyl)-7,8-dihydro-1,3-Dioxolo[4,5-g]quinolin-6(5H)-one price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0413 | FQI1 ≥98% (HPLC) | 599151-35-6 | 25mg | $472 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML0413 | FQI1 ≥98% (HPLC) | 599151-35-6 | 5mg | $111 | 2025-07-31 | Buy |
| Cayman Chemical | 23104 | FQI 1 ≥98% | 599151-35-6 | 5mg | $120 | 2026-04-30 | Buy |
| Cayman Chemical | 23104 | FQI 1 ≥98% | 599151-35-6 | 10mg | $213 | 2026-04-30 | Buy |
| Cayman Chemical | 23104 | FQI 1 ≥98% | 599151-35-6 | 25mg | $472 | 2026-04-30 | Buy |
8-(2-Ethoxyphenyl)-7,8-dihydro-1,3-Dioxolo[4,5-g]quinolin-6(5H)-one Chemical Properties, Uses, Production
Description
FQI1 (599151-35-6) is an inhibitor of transcription factor LSF specifically targeting its DNA binding and corresponding transcriptional activity (IC50=2.1 μM). Rapidly induces apoptosis in an aggressive hepatocellular carcinoma (HCC) cell line and dramatically inhibits tumor growth in a mouse xenograft model with no general tissue cytotoxicity.1,2In human HCC cells, FQI1 induced mitotic arrest with an accompanying increase in cyclin B1.3Blocks LSF-stimulated activation of DNA methyltransferase 1.4Cell permeable.
Uses
FQI1 is a Late SV40 Factor (LSF) inhibitor. FQI1 inhibits cell proliferation, with IC50s of 3, 0.79, 6.3 μM for NIH/3T3, HeLa, A549 cells. FQI1 can be used for cancer research[1].
References
[1] TREVOR J GRANT. Antiproliferative small-molecule inhibitors of transcription factor LSF reveal oncogene addiction to LSF in hepatocellular carcinoma.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2012: 4503-4508. DOI:10.1073/pnas.1121601109
[2] PRASANNA K SANTHEKADUR. The transcription factor LSF: a novel oncogene for hepatocellular carcinoma.[J]. American journal of cancer research, 2012, 2 3: 269-285.
[3] DEVARAJA RAJASEKARAN. Small molecule inhibitors of Late SV40 Factor (LSF) abrogate hepatocellular carcinoma (HCC): Evaluation using an endogenous HCC model.[J]. Oncotarget, 2015: 26266-26277. DOI:10.18632/oncotarget.4656
[4] H. CHIN. Transcription factor LSF-DNMT1 complex dissociation by FQI1 leads to aberrant DNA methylation and gene expression[J]. Oncotarget, 2016, 7 1: 83627-83640. DOI:10.18632/oncotarget.13271
8-(2-Ethoxyphenyl)-7,8-dihydro-1,3-Dioxolo[4,5-g]quinolin-6(5H)-one Preparation Products And Raw materials
Raw materials
Preparation Products
8-(2-Ethoxyphenyl)-7,8-dihydro-1,3-Dioxolo[4,5-g]quinolin-6(5H)-one Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Pharmacodia (Beijing) Co.,Ltd | +86-400-851-9921 | sales@pharmacodia.com | China | 2308 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9729 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Lynnchem | 86-(0)29-85992781 17792393971 | info@lynnchem.com | China | 4578 | 58 |
| Novachemistry | 44-20819178-90 02081917890 | info@novachemistry.com | United Kingdom | 4372 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Jingmo (Xiamen) Biotechnology Co., Ltd | 13621943973; 13621943973 | sales@jamxmpharmatech.com | China | 1191 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44871 | 58 |
