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4-CHLORO-2-METHYLQUINOLINE

4-CHLORO-2-METHYLQUINOLINE structure

CAS No.: 4295-06-1

Chemical Name:: 4-CHLORO-2-METHYLQUINOLINE

Synonyms: Compound Fr13648;AKOS BBS-00000956;4-CHLOROQUINALDINE;TIMTEC-BB SBB005362;Quinaldine, 4-chloro-;4-Chloroquinaldine 99%;4-CHLORO-2-METHYLQUINOLINE;2-Methyl-4-chloroquinoline;4-Chloro-2-methylquinoline>Quinoline, 4-chloro-2-methyl-

CBNumber:: CB4286158

Molecular Formula:: C10H8ClN

Molecular Weight:: 177.63

MDL Number:: MFCD00006757

MOL File:: 4295-06-1.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 05:46:33

Product description	Number	Pack Size	Price
4-Chloroquinaldine 99%	150231	5g	$118
4-Chloroquinaldine 99%	150231	25g	$565
4-Chloro-2-methylquinoline >98.0%(GC)	C2901	5g	$106
4-Chloro-2-methylquinoline 97%	AS118577	1g	$25
4-Chloro-2-methylquinoline 97%	AS118577	5g	$58

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4-CHLORO-2-METHYLQUINOLINE Properties

Melting point	39 °C
Boiling point	269-270 °C (lit.)
Density	0.881 g/mL at 25 °C (lit.)
refractive index	n20/D 1.622(lit.)
Flash point	>230 °F
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
form	powder to lump to clear liquid
pka	4.40±0.50(Predicted)
color	White or Colorless to Yellow
Water Solubility	Slightly soluble in water.
BRN	3522
InChI	InChI=1S/C10H8ClN/c1-7-6-9(11)8-4-2-3-5-10(8)12-7/h2-6H,1H3
InChIKey	HQAIROMRVBVWSK-UHFFFAOYSA-N
SMILES	N1C2C(=CC=CC=2)C(Cl)=CC=1C
CAS DataBase Reference	4295-06-1(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-37/39

WGK Germany

HS Code

2933499090

Storage Class

10 - Combustible liquids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	0
2		0

4-CHLORO-2-METHYLQUINOLINE price More Price(68)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	150231	4-Chloroquinaldine 99%	4295-06-1	5g	$118	2023-01-07	Buy
Sigma-Aldrich	150231	4-Chloroquinaldine 99%	4295-06-1	25g	$565	2023-01-07	Buy
TCI Chemical	C2901	4-Chloro-2-methylquinoline >98.0%(GC)	4295-06-1	5g	$106	2026-04-30	Buy
Activate Scientific	AS118577	4-Chloro-2-methylquinoline 97%	4295-06-1	1g	$25	2026-06-04	Buy
Activate Scientific	AS118577	4-Chloro-2-methylquinoline 97%	4295-06-1	5g	$58	2026-06-04	Buy

Product number	Packaging	Price	Buy
150231	5g	$118	Buy
150231	25g	$565	Buy
C2901	5g	$106	Buy
AS118577	1g	$25	Buy
AS118577	5g	$58	Buy

4-CHLORO-2-METHYLQUINOLINE Chemical Properties,Uses,Production

Chemical Properties

Melting point 42-43℃, boiling point 269-270℃, 83℃ (93Pa), relative density 0.881, refractive index 1.6224. Slightly soluble in water.

Uses

4-Chloroquinaldine is used in the preparation of 4-phenyl-hydrazinoquinaldine

Synthesis

607-67-0

4295-06-1

General procedure: 4-hydroxy-2-methylquinoline (5a-c) was added to POCl3 and the reaction mixture was heated to reflux for 12 hours. Upon completion of the reaction, the excess POCl3 was removed by distillation under reduced pressure. the residue was washed once and twice each with CHCl3 and toluene sequentially. The solid obtained was dissolved in CH2Cl2 and triethylamine was added dropwise until the pH of the aqueous wash solution was greater than 10. Finally, the reaction mixture was filtered to afford the target products 2-methyl-4-chloroquinoline (6a-c).

References

[1] European Journal of Medicinal Chemistry, 2017, vol. 138, p. 1114 - 1125
[2] Patent: US2008/171765, 2008, A1. Location in patent: Page/Page column 19-20
[3] Australian Journal of Chemistry, 2003, vol. 56, # 1, p. 39 - 44
[4] Letters in Drug Design and Discovery, 2018, vol. 15, # 9, p. 937 - 944
[5] Patent: WO2018/178277, 2018, A1. Location in patent: Paragraph 00114

4-CHLORO-2-METHYLQUINOLINE synthesis

Synthesis of 4-CHLORO-2-METHYLQUINOLINE from 4-Hydroxy-2-methylquinoline

4-CHLORO-2-METHYLQUINOLINE Preparation Products And Raw materials

Raw materials

Ethyl acetoacetate Diphenyl ether Phosphorus oxitrichloride Methyl acetoacetate Ethyl crotonate

4-Hydroxy-2-methylquinoline Phosphorus pentachloride Aniline Hydrochloric acid Dichloromethane

Phosphorus pentoxide Petroleum ether Ethyl 3-anilinocrotonate, 97% Ethyl 3-anilinobut-2-enoate 4-Chloroquinoline

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Preparation Products

4-AMINO-2-METHYLQUINOLINE SVFHMQGYXMIBND-UHFFFAOYSA-N 4-HYDRAZINO-2-METHYLQUINOLINE HYDROCHLORIDE quindecamine

4-CHLORO-2-METHYLQUINOLINE Suppliers

Global( 137)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
Hubei Ipure Biology Co., Ltd	+8613367258412	ada@ipurechemical.com	China	10236	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
HONG KONG IPURE BIOLOGY CO.,LIMITED	86 18062405514 18062405514	ada@ipurechemical.com	CHINA	3461	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	28292	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 +8617705817739	info@dycnchem.com	China	52704	58
Labnetwork lnc.	+86-27-50766799 +8618062016861	contact@labnetwork.com	China	19987	58
ZHEJIANG ESTCHEM CO.,LTD	15957180504	sales@zjestchem.com	China	193	58
HANGZHOU LEAP CHEM CO., LTD.	+86-571-87711850	market18@leapchem.com	China	24597	58

Supplier	Advantage
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Hubei Ipure Biology Co., Ltd	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
HONG KONG IPURE BIOLOGY CO.,LIMITED	58
Dideu Industries Group Limited	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Labnetwork lnc.	58
ZHEJIANG ESTCHEM CO.,LTD	58
HANGZHOU LEAP CHEM CO., LTD.	58

View Lastest Price from 4-CHLORO-2-METHYLQUINOLINE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-11-18	4-CHLORO-2-METHYLQUINOLINE 4295-06-1	$1.10	1g	99.00%	100 Tons	Dideu Industries Group Limited

4-CHLORO-2-METHYLQUINOLINE
4295-06-1
$1.10
99.00%
Dideu Industries Group Limited

4-CHLORO-2-METHYLQUINOLINE Spectrum

4-CHLORO-2-METHYLQUINOLINE(4295-06-1)¹HNMR 4-CHLORO-2-METHYLQUINOLINE(4295-06-1)Raman 4-CHLORO-2-METHYLQUINOLINE(4295-06-1)FT-IR 4-CHLORO-2-METHYLQUINOLINE(4295-06-1)IR

4295-06-1(4-CHLORO-2-METHYLQUINOLINE)Related Search:

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JR-8354, 4-Chloroquinaldine, 97% TIMTEC-BB SBB005362 AKOS BBS-00000956 4-CHLOROQUINALDINE 4-CHLORO-2-METHYLQUINOLINE Quinaldine, 4-chloro- Quinoline, 4-chloro-2-methyl- 2-Methyl-4-chloroquinoline 4-Chloroquinaldine 99% 4-Chloro-2-methylquinoline> 4-CHLORO-2-METHYLQUINOLINE ISO 9001：2015 REACH Compound Fr13648 4295-06-1 Building Blocks Quinaldines Halogenated Heterocycles Heterocyclic Building Blocks Quinolines, Isoquinolines & Quinoxalines QuinaldinesHeterocyclic Building Blocks Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks Quinaldines Quinolines Halides Quinolines, Isoquinolines & Quinoxalines