3,4-Dimethoxyphenethylamine
- CAS No.
- 120-20-7
- Chemical Name:
- 3,4-Dimethoxyphenethylamine
- Synonyms
- HOMOVERATRYLAMINE;dmpea;2-(3,4-Dimethoxyphenyl)ethanamine;DiMethoxyphenethylaMine;2-(3,4-DIMETHOXYPHENYL)ETHYLAMINE;Dimethoxyphenylethylamine;Dopamine Hydrochloride EP Impurity C;HVTA;Homoveratrile Amine;3,4-DIMETHOXY PHENYLETHYLAMINE
- CBNumber:
- CB4294076
- Molecular Formula:
- C10H15NO2
- Molecular Weight:
- 181.23
- MDL Number:
- MFCD00008188
- MOL File:
- 120-20-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 12-15 °C |
|---|---|
| Boiling point | 188 °C15 mm Hg(lit.) |
| Density | 1.074 g/mL at 25 °C(lit.) |
| vapor pressure | 0.348-0.348Pa at 25℃ |
| refractive index |
n |
| Flash point | >230 °F |
| storage temp. | Refrigerator |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| pka | 9.74±0.10(Predicted) |
| form | Viscous Liquid |
| Specific Gravity | 1.10 |
| color | Clear light yellow to orange or slightly brownish |
| PH | 11.4 (100g/l, H2O, 20℃) |
| explosive limit | 0.1-1.7%(V) |
| Water Solubility | SOLUBLE |
| Sensitive | Air Sensitive |
| InChI | 1S/C10H15NO2/c1-12-9-4-3-8(5-6-11)7-10(9)13-2/h3-4,7H,5-6,11H2,1-2H3 |
| InChIKey | ANOUKFYBOAKOIR-UHFFFAOYSA-N |
| SMILES | COc1ccc(CCN)cc1OC |
| LogP | 0.77 |
| CAS DataBase Reference | 120-20-7(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | IQF9T435OP |
| NIST Chemistry Reference | Benzeneethanamine, 3,4-dimethoxy-(120-20-7) |
| EPA Substance Registry System | Benzeneethanamine, 3,4-dimethoxy- (120-20-7) |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H315-H317-H318 | |||||||||
| Precautionary statements | P261-P264-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26-36-37/39 | |||||||||
| RIDADR | UN 2735 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | SH2300000 | |||||||||
| F | 10 | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29222900 | |||||||||
| Storage Class | 10 - Combustible liquids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Dam. 1 Skin Irrit. 2 Skin Sens. 1B |
|||||||||
| Toxicity | mouse,LD50,intraperitoneal,181mg/kg (181mg/kg),Yakugaku Zasshi. Journal of Pharmacy. Vol. 97, Pg. 1117, 1977. | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
3,4-Dimethoxyphenethylamine price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | D0678 | Homoveratrylamine >98.0%(GC)(T) | 120-20-7 | 25g | $50 | 2026-04-30 | Buy |
| TCI Chemical | D0678 | Homoveratrylamine min. 98.0 % | 120-20-7 | 100G | $143 | 2026-04-30 | Buy |
| TCI Chemical | D0678 | Homoveratrylamine >98.0%(GC)(T) | 120-20-7 | 500g | $456 | 2026-04-30 | Buy |
| TRC | TRC-H669540-5G | Homoveratrylamine >95%(HPLC) | 120-20-7 | 5g | $83 | 2026-06-03 | Buy |
| TRC | TRC-H669540-50G | Homoveratrylamine >95%(HPLC) | 120-20-7 | 50g | $181 | 2026-06-03 | Buy |
3,4-Dimethoxyphenethylamine Chemical Properties,Uses,Production
Description
3,4-Dimethoxyphenylethylamine, also known as 3,4-DMPEA or DMPEA is an endogenous metabolite found in urine that belongs to both the phenethylamine and catecholamine families. DMPEA is an analogue of dopamine (3,4-dihydroxyphenethylamine), with a substitution of the hydroxy groups with methoxy groups. It is also structurally similar to mescaline (3,4,5-trimethoxyphenylethylamine) and occurs naturally alongside it in various species of cacti such as the San Pedro and Peruvian Torch. DMPEA received wide attention after it was proposed as a biomarker in schizophrenic patients urine, however later studies revealed that DMPEA is also excreted by non-schizophrenics. DMPEA has little known bioactivity, but it has some action as a monoamine oxidase inhibitor. It has also been shown to have neurotoxic effects, especially in the nigrostriatal system and among dopaminergic neurons. DMPEA appears to be an inhibitor of mitochondrial complex I.
Chemical Properties
3,4-Dimethoxyphenethylamine is clear yellowish oil
Occurrence
3,4-Dimethoxyphenethylamine is a natural product found in Pilosocereus leucocephalus, Vachellia rigidula, and Ototropis elegans with data available.
Uses
Precursor for the synthesis of isoquinolines.
Uses
3,4-Dimethoxyphenethylamine is a methylated metabolite of Dopamine (D533780); a potent inhibitor of brain mitochondrial respiration used in Parkinson’s disease studies.
Definition
ChEBI: An aromatic ether that is the derivative of 2-phenylethylamine with methoxy substituents at the 3- and 4-positions. It is an alkaloid isolated from the Cactaceae family.
Flammability and Explosibility
Not classified
Safety Profile
Poison by intravenous and intraperitoneal routes. When heated to decomposition it emits toxic fumes of NOx.
Purification Methods
Purify the amine by fractionation through an efficient column in an inert atmosphere as it is a relatively strong base. [Horner & Sturm Justus Liebigs Ann Chem 608 12819 1957, Jung et al. J Am Chem Soc 75 4664 1953.] The hydrochloride has m 152o, 154o, 156o (from EtOH, Me2CO or EtOH/Et2O), the picrate has m 165-167o(dec), and the 4-nitrobenzoyl derivative has m 147o [Buck J Am Chem Soc 55 2593 1933]. [Beilstein 13 H 800, 13 IV 2604.]
3,4-Dimethoxyphenethylamine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Lianyungang Shenghe Biotechnology Co., Ltd. | 0518-87108777 13585296001 | haizaofu@163.com | China | 44 | 58 |
| Jiangsu Shenghe Pharmaceutical Technology Co., Ltd | 15151219790 | 895190506@qq.com | China | 95 | 58 |
| Jinan Dexinjia Bio&Tech Co., Ltd | 0531-82375880 15098789112 | 3845379039@qq.com | China | 1459 | 58 |
| Shanghai Witofly Chemical Co. ,Ltd. | 02150630626 17717886015 | sales@witofly.com | China | 1864 | 55 |
| Shanghai RC Chemicals Co. Ltd | 17305617782 | sales1@rcc.net.cn | China | 213 | 55 |
| Henan Wanxiang Chemical Industry Co.,Ltd. | 0371-56669001 13949088811 | Sales@58chem.cn | China | 296 | 58 |
| Gansu Songsheng Pharmaceutical Co. , Ltd. | 13705130158 | sales@unitechemical.com | China | 145 | 58 |
| Shanghai Qiao Chemical Science Co., Ltd | 021-58892003 | info@qiaochem.com | China | 6065 | 65 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
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- 3,4-Dimethoxyphenethylamine: A Phenethylamine Analogue
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- Dec 18,2025
View Lastest Price from 3,4-Dimethoxyphenethylamine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-11 | 3,4-Dimethoxyphenethylamine
120-20-7
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
 |
2026-09-11 | 3,4-Dimethoxyphenylethylamine
120-20-7
|
$20.00 | 1KG | 99% | 300 Tons/ year | Speranza Chemical Co., Ltd.
|
|
 |
2026-07-30 | 3,4-Dimethoxyphenethylamine
120-20-7
|
$10.00-150.00 | 1kg | NLT98% | 2 ton per month | Anhui Dexinjia Biopharm Co., Ltd
|
-
- 3,4-Dimethoxyphenethylamine
120-20-7
- 0.99
- RongNa Biotechnology Co.,Ltd
-
- 3,4-Dimethoxyphenylethylamine
120-20-7
- $20.00
- 99%
- Speranza Chemical Co., Ltd.
-
- 3,4-Dimethoxyphenethylamine
120-20-7
- $10.00-150.00
- NLT98%
- Anhui Dexinjia Biopharm Co., Ltd
