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6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride

6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride structure

CAS No.: 2328-12-3

Chemical Name:: 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride

Synonyms: 7-DiMethoxy-1;TIMTEC-BB SBB003285;LABOTEST-BB LT00453025;HeliaMine Hydrochloride;4-tetrahydroisoquinoline hydrochloride;6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoL;6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinolineHCl;isoquinoline, 1,2,3,4-tetrahydro-6,7-dimethoxy-;6,7-Dimethoxy-1,2,3,4-tetrahydroisochinoline*HCl;6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline,chloride

CBNumber:: CB0306261

Molecular Formula:: C11H16ClNO2

Molecular Weight:: 229.7

MDL Number:: MFCD00012744

MOL File:: 2328-12-3.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-24 14:59:07

Product description	Number	Pack Size	Price
6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride 97%	291919	5g	$23
6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride 97%	291919	25g	$45.4
6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline Hydrochloride >98.0%(T)	D2472	5g	$35
6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline Hydrochloride >98.0%(T)	D2472	25g	$88
6,7-DIMETHOXY-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HCL 97%	60324	5G	$17
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6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride Properties

Melting point	260-265 °C(lit.)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	soluble25mg/mL, clear, colorless (1N NaOH in methanol)
form	Shiny Flakes or Crystalline Powder
color	White to slightly beige
Water Solubility	soluble 25mg/mL, clear, colorless (1N NaOH in methanol)
BRN	3634126
InChI	InChI=1S/C11H15NO2.ClH/c1-13-10-5-8-3-4-12-7-9(8)6-11(10)14-2;/h5-6,12H,3-4,7H2,1-2H3;1H
InChIKey	SHOWAGCIRTUYNA-UHFFFAOYSA-N
SMILES	C12CCNCC=1C=C(OC)C(OC)=C2.Cl
CAS DataBase Reference	2328-12-3(CAS DataBase Reference)
EWG's Food Scores	1
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P280a-P304+P340-P305+P351+P338-P405-P501a

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

RTECS

NX5017980

HazardClass

IRRITANT

HS Code

29334900

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

Toxicity

mouse,LD50,intraperitoneal,272mg/kg (272mg/kg),BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLDBEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY),Yakugaku Zasshi. Journal of Pharmacy. Vol. 88, Pg. 1197, 1968.

NFPA 704

	1
2		1

6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride price More Price(54)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	291919	6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride 97%	2328-12-3	5g	$23	2023-06-20	Buy
Sigma-Aldrich	291919	6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride 97%	2328-12-3	25g	$45.4	2023-01-07	Buy
TCI Chemical	D2472	6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline Hydrochloride >98.0%(T)	2328-12-3	5g	$35	2026-04-30	Buy
TCI Chemical	D2472	6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline Hydrochloride >98.0%(T)	2328-12-3	25g	$88	2026-04-30	Buy
AstaTech	60324	6,7-DIMETHOXY-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HCL 97%	2328-12-3	5G	$17	2026-04-30	Buy

Product number	Packaging	Price	Buy
291919	5g	$23	Buy
291919	25g	$45.4	Buy
D2472	5g	$35	Buy
D2472	25g	$88	Buy
60324	5G	$17	Buy

6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride Chemical Properties,Uses,Production

Chemical Properties

white to slightly beige shiny flakes or

Uses

6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride has been used as starting material for the synthesis of more complex isoquinolines and quinolizidines.

Definition

ChEBI: 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride is a member of isoquinolines.

General Description

6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride is also referred as heliamine. It is an alkaloid isolated from mexican cereoid, Backebergia militaris.

Synthesis

50-00-0

120-20-7

6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride

2328-12-3

In a 250 mL single neck flask, 3,4-dimethoxyphenethylamine (18.1 g, 100 mmol), paraformaldehyde (3.6 g, 120 mmol) and anhydrous ethanol (30 mL) were added sequentially. Upon completion of the reaction, the mixture was cooled to room temperature and white crystals were collected by filtration to yield 14.2 g of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride in 61.8% yield.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 20, p. 5285 - 5289
[2] Patent: CN107573325, 2018, A. Location in patent: Paragraph 0109; 0110; 0111
[3] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 9, p. 2420 - 2427
[4] Pharmazie, 1990, vol. 45, # 6, p. 408 - 410
[5] Journal of the American Chemical Society, 1934, vol. 56, p. 1769

6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride synthesis

Synthesis of 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride from Formaldehyde and 3,4-Dimethoxyphenethylamine

6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride Preparation Products And Raw materials

Raw materials

bis(6,7-diMethoxy-3,4-dihydroisoquinolin-2(1H)-yl)Methane Formaldehyde 3,4-Dimethoxyphenethylamine Hydrochloric acid Water

Ethanol Dimethoxymethane

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Preparation Products

6,7-DIMETHOXYISOQUINOLINE Hydrogen 2(1H)-Isoquinolinebutanamine, 3,4-dihydro-6,7-dimethoxy- N-(4-(2-(6,7-diMethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)nicotinaMide

6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride Suppliers

Global( 203)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai UCHEM Inc.	+862156762820 +86-13564624040	sales@myuchem.com	China	8671	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29640	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29816	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21142	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17346	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	18895	58
AFINE CHEMICALS LIMITED	+86-0571-85134551	sales@afinechem.com	China	15082	58

Supplier	Advantage
Shanghai UCHEM Inc.	58
Capot Chemical Co.,Ltd.	60
career henan chemical co	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
SIMAGCHEM CORP	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Dideu Industries Group Limited	58
AFINE CHEMICALS LIMITED	58

View Lastest Price from 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-05-20	6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride 2328-12-3	US $15.00-368.00 / g	25g	0.98	25kg	Shanghai UCHEM Inc.
2021-08-12	6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride 2328-12-3	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2021-07-02	6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline Hydrochloride 2328-12-3	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd

6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride
2328-12-3
US $15.00-368.00 / g
0.98
Shanghai UCHEM Inc.

6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride
2328-12-3
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline Hydrochloride
2328-12-3
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride Spectrum

6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride(2328-12-3)¹HNMR 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride(2328-12-3)IR 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride(2328-12-3)Raman 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride(2328-12-3)FT-IR

2328-12-3(6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride)Related Search:

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1of4

1,2,3,4-tetrahydro-6,7-dimethoxy-isoquinolinhydrochloride 1,2,3,4-TETRAHYDRO-6,7-DIMETHOXY-ISOQUINOLINE HYDROCHLORIDE 6,7-DIMETHOXY-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE LABOTEST-BB LT00453025 ISOQUINOLINE, 1,2,3,4-TETRAHYDRO-6,7-DIMETHOXY-, HYDROCHLORIDE TIMTEC-BB SBB003285 6,7-Dimethoxy-1,2,3,4-tetrahyroisoquinoline hydrochloride, 97% 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinolineHCl 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride 97% 1,2,3,4-TETRAHYDRO-6,7-DIMETHOXY-ISOQUINOLEINE HYDROCHLORIDE 97+% 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinolinehydrochloride,98% isoquinoline, 1,2,3,4-tetrahydro-6,7-dimethoxy- 4-tetrahydroisoquinoline hydrochloride 7-DiMethoxy-1 6,7-DiMethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride(InterMediate of TETRABENAZINE) HeliaMine Hydrochloride 6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-ium chloride Isoquinoline, 6,7-dimethoxy-1,2,3,4-tetrahydro-, hydrochloride 6,7-Dimethoxy-1,2,3,4-tetrahydroisochinoline*HCl 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline,chloride 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinolineHydrochloride> 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoL Isoquinoline, 1,2,3,4-tetrahydro-6,7-dimethoxy-, hydrochloride (1:1) 6,7-DIMETHOXY-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE 2328-12-3 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride ISO 9001：2015 REACH 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-ium chloride 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride TETRABENAZINE 2328-12-3 2328-12-03 156-66-2 C11H15NO2HCl Building Blocks Isoquinolines Heterocyclic Building Blocks Building Blocks Heterocyclic Building Blocks Isoquinolines API intermediates