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6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride

6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride structure

CAS No.: 2328-12-3

Chemical Name:: 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride

Synonyms: 7-DiMethoxy-1;TIMTEC-BB SBB003285;LABOTEST-BB LT00453025;HeliaMine Hydrochloride;4-tetrahydroisoquinoline hydrochloride;6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoL;6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinolineHCl;isoquinoline, 1,2,3,4-tetrahydro-6,7-dimethoxy-;6,7-Dimethoxy-1,2,3,4-tetrahydroisochinoline*HCl;6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline,chloride

CBNumber:: CB0306261

Molecular Formula:: C11H16ClNO2

Molecular Weight:: 229.7

MDL Number:: MFCD00012744

MOL File:: 2328-12-3.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-27 17:38:35

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6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride Properties

Melting point	260-265 °C(lit.)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	soluble25mg/mL, clear, colorless (1N NaOH in methanol)
form	Shiny Flakes or Crystalline Powder
color	White to slightly beige
Water Solubility	soluble 25mg/mL, clear, colorless (1N NaOH in methanol)
BRN	3634126
InChI	InChI=1S/C11H15NO2.ClH/c1-13-10-5-8-3-4-12-7-9(8)6-11(10)14-2;/h5-6,12H,3-4,7H2,1-2H3;1H
InChIKey	SHOWAGCIRTUYNA-UHFFFAOYSA-N
SMILES	C12CCNCC=1C=C(OC)C(OC)=C2.Cl
CAS DataBase Reference	2328-12-3(CAS DataBase Reference)
EWG's Food Scores	1
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P280a-P304+P340-P305+P351+P338-P405-P501a

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

RTECS

NX5017980

HazardClass

IRRITANT

HS Code

29334900

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

Toxicity

mouse,LD50,intraperitoneal,272mg/kg (272mg/kg),BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLDBEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY),Yakugaku Zasshi. Journal of Pharmacy. Vol. 88, Pg. 1197, 1968.

NFPA 704

	1
2		1

6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride price More Price(70)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	291919	6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride 97%	2328-12-3	5g	$23	2023-06-20	Buy
Sigma-Aldrich	291919	6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride 97%	2328-12-3	25g	$45.4	2023-01-07	Buy
TCI Chemical	D2472	6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline Hydrochloride >98.0%(T)	2328-12-3	5g	$35	2026-04-30	Buy
TCI Chemical	D2472	6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline Hydrochloride >98.0%(T)	2328-12-3	25g	$88	2026-04-30	Buy
Usbiological	271069	6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride Asreported	2328-12-3	5g	$333	2026-06-03	Buy

Product number	Packaging	Price	Buy
291919	5g	$23	Buy
291919	25g	$45.4	Buy
D2472	5g	$35	Buy
D2472	25g	$88	Buy
271069	5g	$333	Buy

6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride Chemical Properties,Uses,Production

Chemical Properties

white to slightly beige shiny flakes or

Uses

6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride has been used as starting material for the synthesis of more complex isoquinolines and quinolizidines.

Definition

ChEBI: 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride is a member of isoquinolines.

General Description

6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride is also referred as heliamine. It is an alkaloid isolated from mexican cereoid, Backebergia militaris.

Synthesis

50-00-0

120-20-7

6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride

2328-12-3

In a 250 mL single neck flask, 3,4-dimethoxyphenethylamine (18.1 g, 100 mmol), paraformaldehyde (3.6 g, 120 mmol) and anhydrous ethanol (30 mL) were added sequentially. Upon completion of the reaction, the mixture was cooled to room temperature and white crystals were collected by filtration to yield 14.2 g of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride in 61.8% yield.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 20, p. 5285 - 5289
[2] Patent: CN107573325, 2018, A. Location in patent: Paragraph 0109; 0110; 0111
[3] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 9, p. 2420 - 2427
[4] Pharmazie, 1990, vol. 45, # 6, p. 408 - 410
[5] Journal of the American Chemical Society, 1934, vol. 56, p. 1769

6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride synthesis

Synthesis of 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride from Formaldehyde and 3,4-Dimethoxyphenethylamine

6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride Preparation Products And Raw materials

Raw materials

bis(6,7-diMethoxy-3,4-dihydroisoquinolin-2(1H)-yl)Methane Formaldehyde 3,4-Dimethoxyphenethylamine Hydrochloric acid Water

Ethanol Dimethoxymethane

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Preparation Products

6,7-DIMETHOXYISOQUINOLINE Hydrogen 2(1H)-Isoquinolinebutanamine, 3,4-dihydro-6,7-dimethoxy- N-(4-(2-(6,7-diMethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)nicotinaMide

6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride Suppliers

Global( 202)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
MIDECO	68625073 15723208759	lidaijun@midecopharm.com	China	55	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10174	62
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32273	50
XiaoGan ShenYuan ChemPharm co,ltd	15527621225; 15527621225	1791901229@qq.com	China	6746	52
Beijing Isomersyn Technology CO;LTD	010-82954736 13391601435	sales@isomersyn.com	China	3294	57

Supplier	Advantage
MIDECO	58
J & K SCIENTIFIC LTD.	76
Alfa Aesar	84
TCI (Shanghai) Development Co., Ltd.	81
Energy Chemical	61
Pure Chemistry Scientific Inc.	62
Shanghai Hanhong Scientific Co.,Ltd.	64
Chemsky（shanghai）International Co.,Ltd.	50
XiaoGan ShenYuan ChemPharm co,ltd	52
Beijing Isomersyn Technology CO;LTD	57

View Lastest Price from 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-11	6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride 2328-12-3	$15.00-368.00	25g	0.98	25kg	Shanghai UCHEM Inc.
2021-08-12	6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride 2328-12-3	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd
2021-07-02	6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline Hydrochloride 2328-12-3	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd

6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride
2328-12-3
$15.00-368.00
0.98
Shanghai UCHEM Inc.

6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride
2328-12-3
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline Hydrochloride
2328-12-3
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride Spectrum

6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride(2328-12-3)¹HNMR 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride(2328-12-3)IR 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride(2328-12-3)Raman 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride(2328-12-3)FT-IR

2328-12-3(6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride)Related Search:

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1-(3,4-Dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride 1-BENZYL-6,7-DIMETHOXY-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE 5,6,7,8-TETRAHYDROISOQUINOLINE

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1,2,3,4-tetrahydro-6,7-dimethoxy-isoquinolinhydrochloride 1,2,3,4-TETRAHYDRO-6,7-DIMETHOXY-ISOQUINOLINE HYDROCHLORIDE 6,7-DIMETHOXY-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE LABOTEST-BB LT00453025 ISOQUINOLINE, 1,2,3,4-TETRAHYDRO-6,7-DIMETHOXY-, HYDROCHLORIDE TIMTEC-BB SBB003285 6,7-Dimethoxy-1,2,3,4-tetrahyroisoquinoline hydrochloride, 97% 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinolineHCl 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride 97% 1,2,3,4-TETRAHYDRO-6,7-DIMETHOXY-ISOQUINOLEINE HYDROCHLORIDE 97+% 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinolinehydrochloride,98% isoquinoline, 1,2,3,4-tetrahydro-6,7-dimethoxy- 4-tetrahydroisoquinoline hydrochloride 7-DiMethoxy-1 6,7-DiMethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride(InterMediate of TETRABENAZINE) HeliaMine Hydrochloride 6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-ium chloride Isoquinoline, 6,7-dimethoxy-1,2,3,4-tetrahydro-, hydrochloride 6,7-Dimethoxy-1,2,3,4-tetrahydroisochinoline*HCl 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline,chloride 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinolineHydrochloride> 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoL Isoquinoline, 1,2,3,4-tetrahydro-6,7-dimethoxy-, hydrochloride (1:1) 6,7-DIMETHOXY-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE 2328-12-3 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride ISO 9001：2015 REACH 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-ium chloride 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride TETRABENAZINE 2328-12-3 2328-12-03 156-66-2 C11H15NO2HCl Building Blocks Isoquinolines Heterocyclic Building Blocks Building Blocks Heterocyclic Building Blocks Isoquinolines API intermediates