3-Amino-2-butenoic acid ethyl ester
- CAS No.
- 7318-00-5
- Chemical Name:
- 3-Amino-2-butenoic acid ethyl ester
- Synonyms
- ETHYL 3-AMINOCROTONATE;Ethyl (E)-3-aminobut-2-enoate;Ethyl β-aminobutenate;ETHYL B-IMINOBUTYRATE;Ethyl 3-Amino-2-butanol;ETHYL 3-AMINO-2-BUTENOATE;ETHYL BETA-AMINOCROTONATE;Ethyl 3-Amino-2-butanol 3;Ethyl3-Amino-2-butenoate>3-Amino-2-butenoic acid ethyl
- CBNumber:
- CB7667095
- Molecular Formula:
- C6H11NO2
- Molecular Weight:
- 129.16
- MDL Number:
- MFCD00008073
- MOL File:
- 7318-00-5.mol
- MSDS File:
- SDS
| Melting point | 33-35 °C(lit.) |
|---|---|
| Boiling point | 210-215 °C(lit.) |
| Density | 1.022 g/mL at 25 °C(lit.) |
| refractive index | 1.5-1.502 |
| Flash point | 207 °F |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | soluble in Chloroform, Methanol |
| form | Low Melting Solid or Liquid |
| pka | 5.32±0.70(Predicted) |
| color | Slightly yellow |
| InChI | InChI=1S/C6H11NO2/c1-3-9-6(8)4-5(2)7/h4H,3,7H2,1-2H3 |
| InChIKey | YPMPTULBFPFSEQ-UHFFFAOYSA-N |
| SMILES | C(OCC)(=O)C=C(N)C |
| CAS DataBase Reference | 7318-00-5(CAS DataBase Reference) |
| NIST Chemistry Reference | 2-Butenoic acid, 3-amino-, ethyl ester(7318-00-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 | |||||||||
| Hazard Codes | C | |||||||||
| Risk Statements | 34-36/37 | |||||||||
| Safety Statements | 26-27-28-36/37/39-45-24/25 | |||||||||
| RIDADR | UN 3263 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29224999 | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
3-Amino-2-butenoic acid ethyl ester price More Price(30)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | E0709 | Ethyl 3-Amino-2-butenoate >98.0%(GC)(T) | 7318-00-5 | 25g | $70 | 2026-04-30 | Buy |
| Usbiological | 449065 | Ethyl 3-Aminocrotonate | 7318-00-5 | 25g | $403 | 2026-06-03 | Buy |
| Usbiological | 449065 | Ethyl 3-Aminocrotonate | 7318-00-5 | 100g | $531 | 2026-06-03 | Buy |
| TRC | TRC-E898080-25G | Ethyl 3-Aminocrotonate | 7318-00-5 | 25g | $189 | 2026-06-03 | Buy |
| TRC | TRC-E898080-250G | Ethyl 3-Aminocrotonate | 7318-00-5 | 250g | $498 | 2026-06-03 | Buy |
3-Amino-2-butenoic acid ethyl ester Chemical Properties, Uses, Production
Chemical Properties
Slightly yellow low melting solid or liquid
Uses
Ethyl 3-Aminocrotonate is used as a reagent to synthesize Nitrendipine (N490150), a calcium channel antagonist that is used to treat patients with hypertension. Ethyl 3-Aminocrotonate is also used as a reagent to synthesize (S)-Felodipine (F232370), a calcium entry blocker that has antihypertensive properties.
Synthesis
141-97-9
626-34-6
General procedure for the synthesis of ethyl 3-aminocrotonate from ethyl acetoacetate: β-keto ester (1.0 eq.), ammonium acetate (3.0 eq.), and acetic acid (dropwise) were dissolved in dry toluene (6 mL) in a 10 mL reaction glass vial containing a stirring magnet and a molecular sieve. The vial was tightly sealed with an Aluminum-Teflon convoluted cap and the mixture was microwaved at 140 °C for 20 min at 60 W power. After completion of the reaction, it was cooled to 50 °C by gas injection. The crude reaction mixture was partitioned between ethyl acetate (15 mL) and saturated sodium bicarbonate solution (15 mL), and the aqueous layer was extracted with ethyl acetate (3 x 15 mL). The organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by rapid chromatography on silica gel.Synthesis of ethyl 3-aminobut-2-enoate (6a): ethyl 3-(2-fluorophenyl)-3-oxopropanoate 5a (1.0 eq.), ammonium acetate (4.0 eq.), and acetic acid (7 drops) were reacted under the above conditions. Rapid chromatographic purification using hexane/ethyl acetate (80:20 to 70:30) as eluent gave an analytically pure product in 89% yield.1H NMR (CDCl3, 300 MHz) δ (ppm): 1.24 (t, 3H, J=7.36 Hz), 3.51 (s, 3H), 4.09 (q, 2H, J=7.28 Hz). 4.60 (s, 1H).
References
[1] Comptes Rendus Chimie, 2011, vol. 14, # 5, p. 511 - 515
[2] Patent: WO2012/147103, 2012, A2. Location in patent: Page/Page column 7
[3] Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1986, vol. 35, p. 1438 - 1442
[4] Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1986, # 7, p. 1586 - 1592
[5] European Journal of Medicinal Chemistry, 2018, vol. 155, p. 946 - 960
3-Amino-2-butenoic acid ethyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| XI'AN VEDA CHEMICAL CO.,LTD | 029-88665278 18392371173 | cordelia@vedachem.com | China | 50 | 58 |
| Shanghai TongYuan Chemical Co., Ltd. | 021-021-69182866 13701855675 | tongyuanchem@126.com | China | 4184 | 58 |
| Hubei Yunmei Technology Co., Ltd | 59206672 18327059871 | service@yunmeichem.com | China | 4916 | 58 |
| Jiangsu ever galaxy chemical co.,ltd. | 0527-81083685 18602515822 | info@egchemical.com | China | 79 | 65 |
| Hubei Hengshuo Chemical Co. Ltd. | 027-82830253 13995541600 | hengshuohg@163.com | China | 494 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
View Latest Price from 3-Amino-2-butenoic acid ethyl ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-01 | Ethyl 3-aminocrotonate
7318-00-5
|
1kg | 99% | 10000kg | Shaanxi TNJONE Pharmaceutical Co., Ltd | ||
 |
2026-03-20 | 3-Amino-2-butenoic acid ethyl ester
7318-00-5
|
$10.00 | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-04-04 | 3-Amino-2-butenoic acid ethyl ester
7318-00-5
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. |
-
- Ethyl 3-aminocrotonate
7318-00-5
- $0.00
- 99%
- Shaanxi TNJONE Pharmaceutical Co., Ltd
-
- 3-Amino-2-butenoic acid ethyl ester
7318-00-5
- $10.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 3-Amino-2-butenoic acid ethyl ester
7318-00-5
- 98%
- Henan Aochuang Chemical Co.,Ltd.
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