ABT-100
- CAS No.
- 450839-40-4
- Chemical Name:
- ABT-100
- Synonyms
- ABT-100;ABT-100 (ABT100);[1,1'-Biphenyl]-3-carbonitrile, 6-[(2S)-2-(4-cyanophenyl)-2-hydroxy-2-(1-methyl-1H-imidazol-5-yl)ethoxy]-4'-(trifluoromethoxy)-
- CBNumber:
- CB43070433
- Molecular Formula:
- C27H19F3N4O3
- Molecular Weight:
- 504.46
- MDL Number:
- MFCD32857139
- MOL File:
- 450839-40-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 722.0±60.0 °C(Predicted) |
|---|---|
| Density | 1.29±0.1 g/cm3(Predicted) |
| storage temp. | -20°C, protect from light |
| solubility |
Acetonitrile: Slightly soluble: 0.1-1 mg/ml DMSO: Sparingly soluble: 1-10 mg/ml |
| form | Solid |
| pka | 12.15±0.29(Predicted) |
| color | White to off-white |
| FDA UNII | QG74WR2HRE |
ABT-100 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 41355 | ABT-100 ≥98% | 450839-40-4 | 1mg | $50 | 2026-04-30 | Buy |
| Cayman Chemical | 41355 | ABT-100 ≥98% | 450839-40-4 | 5mg | $198 | 2026-04-30 | Buy |
| Cayman Chemical | 41355 | ABT-100 ≥98% | 450839-40-4 | 10mg | $372 | 2026-04-30 | Buy |
| ChemScene | CS-0077432 | ABT-100 95.12% | 450839-40-4 | 5mg | $390 | 2026-06-04 | Buy |
| ApexBio Technology | BA2993 | ABT-100 | 450839-40-4 | 1mg | $90 | 2026-05-06 | Buy |
ABT-100 Chemical Properties, Uses, Production
Uses
ABT-100 is a potent, highly selective and orally active farnesyltransferase inhibitor. ABT-100 inhibits cell proliferation (IC50s of 2.2 nM, 3.8 nM, 5.9 nM, 6.9 nM, 9.2 nM, 70 nM and 818 nM for EJ-1, DLD-1, MDA-MB-231, HCT-116, MiaPaCa-2, PC-3, and DU-145 cells, respectively), increases apoptosis and decreases angiogenesis. ABT-100 possesses broad-spectrum antitumor activity[1].
in vivo
ABT-100 (6.25-12.5 mg/kg/day; subcutaneous injection; daily; for 21 days; C.B-17 scid male mice) treatment regresses EJ-1 tumors in mice[1].
| Animal Model: | C.B-17 scid male mice with EJ-1 cells[1] |
| Dosage: | 6.25 mg/kg/day, 12.5 mg/kg/day |
| Administration: | Subcutaneous injection; daily; for 21 days |
| Result: | Regressed EJ-1 tumors in C.B-17 scid male mice. |
References
[1] Ferguson D, et al. Antitumor activity of orally bioavailable farnesyltransferase inhibitor, ABT-100, is mediated by antiproliferative, proapoptotic, and antiangiogenic effects in xenograft models. Clin Cancer Res. 2005 Apr 15;11(8):3045-54. DOI:10.1158/1078-0432.CCR-04-2041
[2] VINICIO CARLONI Pietro P Francesco Vizzutti. Farnesyltransferase inhibitor, ABT-100, is a potent liver cancer chemopreventive agent.[J]. Clinical Cancer Research, 2005, 11 11: 4266-4274. DOI: 10.1158/1078-0432.ccr-04-2386
[3] LOREN G. FONG. A Protein Farnesyltransferase Inhibitor Ameliorates Disease in a Mouse Model of Progeria[J]. Science, 2006, 311 5767. DOI: 10.1126/science.1124875
ABT-100 Preparation Products And Raw materials
Raw materials
Preparation Products
ABT-100 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 27626 | 58 |
| InvivoChem | 13549236410 | sales@invivochem.cn | China | 6745 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Shanghai Yiyan Biotechnology Co. , Ltd. | 021-69985186 13611928337 | 3427709316@qq.com | China | 7982 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 5985 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9831 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 38999 | 58 |
View Latest Price from ABT-100 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-16 | ABT-100
450839-40-4
|
$977.00-1930.00 | 10g | TargetMol Chemicals Inc. | |||
 |
2026-07-15 | ABT-100
450839-40-4
|
$977.00-1930.00 | 10g | TargetMol Chemicals Inc. | |||
 |
2026-01-05 | ABT-100
450839-40-4
|
$977.00-1930.00 | 10g | TargetMol Chemicals Inc. |
