7-NITROINDOLE-3-CARBOXALDEHYDE
- CAS No.
- 10553-14-7
- Chemical Name:
- 7-NITROINDOLE-3-CARBOXALDEHYDE
- Synonyms
- 7-NITRO-1H-INDOLE-3-CARBALDEHYDE;Zinc02572407;7-NITROINDOLE-3-ALDEHYDE;3-Carboxy-7-nitro-1H-indole;7-NITROINDOLE-3-CARBOXALDEHYDE;7-NITROINDOLE-3-CARBOXYALDEHYDE;7-Nitroindole-3-carboxaldehyde 98%;7-Nitro-1H-indole-3-carboxaldehyde;7-Nitroindole-3-carboxaldehyde,97%;(7-nitro-3-indolylidene)methanolate
- CBNumber:
- CB4316686
- Molecular Formula:
- C9H6N2O3
- Molecular Weight:
- 190.16
- MDL Number:
- MFCD01074519
- MOL File:
- 10553-14-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 7-Nitroindole-3-carboxaldehyde Asreported | 285804 | 500mg | $333 |
| 7-Nitroindole-3-carboxaldehyde Asreported | 285804 | 1g | $516 |
| 7-Nitroindole-3-carboxaldehyde Asreported | 285804 | 2g | $706 |
| 7-Nitroindole-3-carboxaldehyde Asreported | 285804 | 5g | $1115 |
| 7-Nitroindole-3-carboxaldehyde Asreported | 285804 | 10g | $1579 |
| More product size | |||
| Boiling point | 441.5±25.0 °C(Predicted) |
|---|---|
| Density | 1.516±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| pka | 12.47±0.30(Predicted) |
| form | Solid |
| Appearance | Light yellow to yellow Solid |
| InChI | InChI=1S/C9H6N2O3/c12-5-6-4-10-9-7(6)2-1-3-8(9)11(13)14/h1-5,10H |
| InChIKey | ADGKBVRTGVODMM-UHFFFAOYSA-N |
| SMILES | N1C2=C(C=CC=C2[N+]([O-])=O)C(C=O)=C1 |
| CAS DataBase Reference | 10553-14-7(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 2933998090 | |||||||||
| NFPA 704 |
|
7-NITROINDOLE-3-CARBOXALDEHYDE price More Price(54)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 285804 | 7-Nitroindole-3-carboxaldehyde Asreported | 10553-14-7 | 500mg | $333 | 2026-06-03 | Buy |
| Usbiological | 285804 | 7-Nitroindole-3-carboxaldehyde Asreported | 10553-14-7 | 1g | $516 | 2026-06-03 | Buy |
| Usbiological | 285804 | 7-Nitroindole-3-carboxaldehyde Asreported | 10553-14-7 | 2g | $706 | 2026-06-03 | Buy |
| Usbiological | 285804 | 7-Nitroindole-3-carboxaldehyde Asreported | 10553-14-7 | 5g | $1115 | 2026-06-03 | Buy |
| Usbiological | 285804 | 7-Nitroindole-3-carboxaldehyde Asreported | 10553-14-7 | 10g | $1579 | 2026-06-03 | Buy |
7-NITROINDOLE-3-CARBOXALDEHYDE Chemical Properties,Uses,Production
Synthesis
6960-42-5
68-12-2
10553-14-7
Phosphorus oxychloride (POCl3, 0.418 mL, 3.13 mmol) was slowly added dropwise to N,N-dimethylformamide (DMF, 2.08 mL) at 0°C and under argon protection. After stirring the reaction mixture for 5 min, a DMF solution of 7-nitroindole (200 mg, 1.25 mmol) was added (at a concentration of 10 mL of DMF per 1 g of indole). Subsequently, the reaction mixture was gradually warmed to room temperature and stirring was continued for 3 hours. After completion of the reaction, 3.8 M aqueous potassium hydroxide solution (3.29 mL, 12.5 mmol) was added to the mixture and stirring was continued for 15 hours. Next, saturated aqueous sodium bicarbonate and ethyl acetate (EtOAc) were added to the reaction system until the mixture became clarified, followed by separation of the organic layer. The aqueous phase was extracted with ethyl acetate and the combined organic layers were washed with brine, dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure. Finally, the residue was purified by silica gel column chromatography (eluent ratio hexane/ethyl acetate = 1/5) to afford the target product 7-nitroindole-3-carbaldehyde (228 mg, 1.20 mmol, 96% yield) as a yellow amorphous solid.
References
[1] Chemical and Pharmaceutical Bulletin, 2018, vol. 66, # 8, p. 810 - 817
[2] European Journal of Medicinal Chemistry, 2013, vol. 65, p. 158 - 167
[3] Tetrahedron Letters, 2009, vol. 50, # 1, p. 75 - 76
[4] Journal of Medicinal Chemistry, 2008, vol. 51, # 23, p. 7541 - 7551
[5] Journal of Organic Chemistry, 2013, vol. 78, # 6, p. 2362 - 2372
7-NITROINDOLE-3-CARBOXALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52704 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +86-571-86217390; +8618058761490 | info@gihichemicals.com | China | 49890 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| Allfluoro pharmaceutical co. ltd. | +86-400-0216110 +86-15958047586 | sales@allfluoro.com | China | 11385 | 58 |
| Nanjing Moldeep Biochemical Co., Ltd. | +86-25-58282389 +8618913958656 | inquiries@moldeep.com | China | 19999 | 58 |
View Lastest Price from 7-NITROINDOLE-3-CARBOXALDEHYDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-06-02 | 7-Nitroindole-3-carboxaldehyde in stock Factory
10553-14-7
|
$1.00 | 1KG | TOP 3 Factory in China | Chemwill Asia Co.,Ltd. | ||
 |
2020-01-03 | 7-NITROINDOLE-3-CARBOXALDEHYDE
10553-14-7
|
$6.60 | 1KG | 97%-99% | 1kg -1000kg | Career Henan Chemical Co |
-
- 7-Nitroindole-3-carboxaldehyde in stock Factory
10553-14-7
- $1.00
- TOP 3 Factory in China
- Chemwill Asia Co.,Ltd.
-
- 7-NITROINDOLE-3-CARBOXALDEHYDE
10553-14-7
- $6.60
- 97%-99%
- Career Henan Chemical Co
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