BETA-ACETYLDIGOXIN
- CAS No.
- 5355-48-6
- Chemical Name:
- BETA-ACETYLDIGOXIN
- Synonyms
- Digotab;digoridb;Cardioreg;novodigal;Cor-puren;B-ACETYLDIGOXIN;2-Acetyl Digoxin;β-Acetyl Digoxin;16’-acetyldigoxin;ACETYLDIGOXIN, B-
- CBNumber:
- CB4328012
- Molecular Formula:
- C43H66O15
- Molecular Weight:
- 822.98
- MDL Number:
- MFCD00242932
- MOL File:
- 5355-48-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 271-273°C |
|---|---|
| alpha | D20 +30.4° (c = 1.2 in alc) |
| Boiling point | 681.03°C (rough estimate) |
| Density | 1.1139 (rough estimate) |
| refractive index | 1.5940 (estimate) |
| storage temp. | -20°C Freezer |
| solubility | Practically insoluble in water, sparingly soluble in methylene chloride, slightly soluble in ethanol (96 per cent). |
| pka | 13.41±0.70(Predicted) |
| Major Application | pharmaceutical (small molecule) |
| InChIKey | NREAGDHHMSOWKZ-UHFFFAOYSA-N |
| SMILES | O1CC(=CC1=O)C2C3(C(C4C(C5(C(CC4)CC(CC5)OC6OC(C(C(C6)O)OC7OC(C(C(C7)O)OC8OC(C(C(C8)O)OC(=O)C)C)C)C)C)CC3O)(CC2)O)C |
| FDA UNII | P7K44M64CW |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H300+H330 |
| Precautionary statements | P260-P301+P330+P331+P310-P304+P340+P310-P403+P233 |
| RIDADR | 3249 |
| WGK Germany | WGK 3 |
| HazardClass | 6.1(a) |
| PackingGroup | II |
| Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials |
| Hazard Classifications | Acute Tox. 2 Inhalation Acute Tox. 2 Oral |
BETA-ACETYLDIGOXIN price More Price(21)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | Y0000642 | β-Acetyldigoxin for peak identification European Pharmacopoeia (EP) Reference Standard | 5355-48-6 | 10 mg | $127 | 2026-04-30 | Buy |
| Sigma-Aldrich | Y0000565 | β-Acetyldigoxin European Pharmacopoeia (EP) Reference Standard | 5355-48-6 | 50 mg | $241 | 2026-04-30 | Buy |
| Sigma-Aldrich | Y0000642 | β-Acetyldigoxin for peak identification European Pharmacopoeia (EP) Reference Standard | 5355-48-6 | y0000642 | $150 | 2024-03-01 | Buy |
| Sigma-Aldrich | Y0000565 | β-Acetyldigoxin European Pharmacopoeia (EP) Reference Standard | 5355-48-6 | y0000565 | $220 | 2024-03-01 | Buy |
| TRC | TRC-A173665-5MG | Beta-Acetyl Digoxin | 5355-48-6 | 5mg | $1344 | 2026-06-03 | Buy |
BETA-ACETYLDIGOXIN Chemical Properties, Uses, Production
Chemical Properties
White Solid
Originator
Novodigal ,Asta Medica Arzneimittel
Uses
Digoxin derivative, a cardiotonic glycosides
Definition
ChEBI: Acetyldigoxin is a cardenolide glycoside.
Manufacturing Process
Dried crude product of the partial acetylation of digoxin (42 g) prepared from
digitalis - is dissolved under reflux in acetone (480 ml) and n-hexane (2400
ml) is added to the solution with stirring. Fine crystals, which begin to
separate immediately, are left at room temperature for 5 hours, then they are
filtered with suction, washed with n-hexane and dried in vacuum at 40°C,
yielding 32 g of crude β-acetyldigoxin (product 1). Product 1 (31 g) is
dissolved under reflux in chloroform (500 ml) and toluene (2500 ml) is added
thereto with stirring. The crystals, which separate after standing for 6 hours at
room temperature, are filtered, washed with toluene and ether and dried in
vacuum yielding 29 g of β-acetyldigoxin (product 2). MP: 249°-251°C.
The filtrate, which results from the separation of product 1, is evaparated to
dryness in vacuum. The residue, which mainly contains unreacted digoxin, is
purified by recrystallization from pyridine/ether/water (3.5:5:40) and
repeatedly acetylated. It can then be recycled to produce more β-
acetyldigoxin. The filtrate resulting from the separation of product 2 is
evaporated to dryness. The resulting residue contains the di- and polyacetyl
derivatives of digoxin, which are deacetylated to digoxin in a known manner and later is returned to a further acetylation process and can then be recycled
to produce more β-acetyldigoxin.
Beta-Acetyldigoxin may be prepared from digoxin, acetic acid and
dicyclohexylcarbodiimide using the last one as a condensing agent.
Therapeutic Function
Cardiotonic
BETA-ACETYLDIGOXIN Preparation Products And Raw materials
BETA-ACETYLDIGOXIN Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| S.Z. PhyStandard Bio-Tech. Co., Ltd. | 0755-83725681-603 | China | 4484 | 50 | |
| Quality Control Solutions Ltd. | 0755-66853366 13670046396 | orders@qcsrm.com | China | 18188 | 56 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 | sales@rrkchem.com | China | 57336 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| AFINE CHEMICALS LIMITED | +86-571-85134551 +86-18958018566 | info@afinechem.com | China | 15030 | 58 |
| Dideu Industries Group Limited | +8617392712697 | 1022@dideu.com | China | 29091 | 58 |
| Guangzhou Dreampharm Biotechnology Co., Ltd. | 020-36607679; 13502246435 | 3008233746@qq.com | China | 9968 | 12 |
| Shenzhen Jianyi Biotechnology Co., Ltd | 0755-84826604 | 3001783715@qq.com | CHINA | 2890 | 58 |
View Latest Price from BETA-ACETYLDIGOXIN manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-04 | BETA-ACETYLDIGOXIN
5355-48-6
|
1KG | 98% | 1tone | Henan Aochuang Chemical Co.,Ltd. |
-
- BETA-ACETYLDIGOXIN
5355-48-6
- 98%
- Henan Aochuang Chemical Co.,Ltd.
